Design and Synthesis of Two Oxazine Derivatives Using Several Strategies
Several oxazine derivatives have been synthesized; nevertheless, expensive reagents and special conditions are required. Therefore, in this study, two oxazine derivatives (2-chloro-3-{{2-[-(3-chloro-2-oxo-cyclobutyl)-(2,3-dimethoxy-9,10-dihydrostrychnid-10-yl)-amino]-ethyl}-[1,5-dimethyl-4-(1H-napht...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2014/757953 |
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| author | Figueroa-Valverde Lauro Díaz-Cedillo Francisco Rosas-Nexticapa Marcela García-Cervera Elodia Pool-Gómez Eduardo López-Ramos María Hau-Heredia Lenin Sarabia-Alcocer Betty |
| author_facet | Figueroa-Valverde Lauro Díaz-Cedillo Francisco Rosas-Nexticapa Marcela García-Cervera Elodia Pool-Gómez Eduardo López-Ramos María Hau-Heredia Lenin Sarabia-Alcocer Betty |
| author_sort | Figueroa-Valverde Lauro |
| collection | DOAJ |
| description | Several oxazine derivatives have been synthesized; nevertheless, expensive reagents and special conditions are required. Therefore, in this study, two oxazine derivatives (2-chloro-3-{{2-[-(3-chloro-2-oxo-cyclobutyl)-(2,3-dimethoxy-9,10-dihydrostrychnid-10-yl)-amino]-ethyl}-[1,5-dimethyl-4-(1H-naphtho[1,2-e][1,3-oxazin-2-yl)-2-phenyl-2,3-dihydro-1H-pyrazol-3-yl]-amino}-cyclobutanone and 2-chloro-3-{{2-[(3-chloro-2-oxo-cyclobutyl)-(1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl)-amino]-ethyl}-[1,5-dimethyl-4-(1H-naphtho[1,2-e][1,3]oxazin-2-yl)-2-phenyl-2,3-dihydro-1H-pyrazol-3-yl]-amino}-cyclobutanone) were synthesized using several strategies. The structure of compounds obtained was confirmed by elemental analysis, spectroscopy, and spectrometry data. In conclusion, the methods used offer some advantages such as good yields, simple procedure, low cost, and ease of workup. |
| format | Article |
| id | doaj-art-ae3567ed30f24a13b01a74343674ed46 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-ae3567ed30f24a13b01a74343674ed462025-02-03T05:55:16ZengWileyJournal of Chemistry2090-90632090-90712014-01-01201410.1155/2014/757953757953Design and Synthesis of Two Oxazine Derivatives Using Several StrategiesFigueroa-Valverde Lauro0Díaz-Cedillo Francisco1Rosas-Nexticapa Marcela2García-Cervera Elodia3Pool-Gómez Eduardo4López-Ramos María5Hau-Heredia Lenin6Sarabia-Alcocer Betty7Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche, Avenida Agustín Melgar s/n, Col Buenavista, 24039 San Francisco de Campeche, CAM, MexicoEscuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional, Prol, Carpio y Plan de Ayala s/n, Col Santo Tomas, 11340 Mexico, DF, MexicoFacultad de Nutrición, Universidad Veracruzana, Médicos y Odontólogos s/n, 91010 Xalapa, VER, MexicoLaboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche, Avenida Agustín Melgar s/n, Col Buenavista, 24039 San Francisco de Campeche, CAM, MexicoLaboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche, Avenida Agustín Melgar s/n, Col Buenavista, 24039 San Francisco de Campeche, CAM, MexicoLaboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche, Avenida Agustín Melgar s/n, Col Buenavista, 24039 San Francisco de Campeche, CAM, MexicoLaboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche, Avenida Agustín Melgar s/n, Col Buenavista, 24039 San Francisco de Campeche, CAM, MexicoFaculty of Medicine, University Autonomous of Campeche, Avenida Patricio Trueba de Regil s/n, Col Lindavista, 24090 San Francisco de Campeche, CAM, MexicoSeveral oxazine derivatives have been synthesized; nevertheless, expensive reagents and special conditions are required. Therefore, in this study, two oxazine derivatives (2-chloro-3-{{2-[-(3-chloro-2-oxo-cyclobutyl)-(2,3-dimethoxy-9,10-dihydrostrychnid-10-yl)-amino]-ethyl}-[1,5-dimethyl-4-(1H-naphtho[1,2-e][1,3-oxazin-2-yl)-2-phenyl-2,3-dihydro-1H-pyrazol-3-yl]-amino}-cyclobutanone and 2-chloro-3-{{2-[(3-chloro-2-oxo-cyclobutyl)-(1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl)-amino]-ethyl}-[1,5-dimethyl-4-(1H-naphtho[1,2-e][1,3]oxazin-2-yl)-2-phenyl-2,3-dihydro-1H-pyrazol-3-yl]-amino}-cyclobutanone) were synthesized using several strategies. The structure of compounds obtained was confirmed by elemental analysis, spectroscopy, and spectrometry data. In conclusion, the methods used offer some advantages such as good yields, simple procedure, low cost, and ease of workup.http://dx.doi.org/10.1155/2014/757953 |
| spellingShingle | Figueroa-Valverde Lauro Díaz-Cedillo Francisco Rosas-Nexticapa Marcela García-Cervera Elodia Pool-Gómez Eduardo López-Ramos María Hau-Heredia Lenin Sarabia-Alcocer Betty Design and Synthesis of Two Oxazine Derivatives Using Several Strategies Journal of Chemistry |
| title | Design and Synthesis of Two Oxazine Derivatives Using Several Strategies |
| title_full | Design and Synthesis of Two Oxazine Derivatives Using Several Strategies |
| title_fullStr | Design and Synthesis of Two Oxazine Derivatives Using Several Strategies |
| title_full_unstemmed | Design and Synthesis of Two Oxazine Derivatives Using Several Strategies |
| title_short | Design and Synthesis of Two Oxazine Derivatives Using Several Strategies |
| title_sort | design and synthesis of two oxazine derivatives using several strategies |
| url | http://dx.doi.org/10.1155/2014/757953 |
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