Application of autogenous vaccine in bitches with transmissible venereal tumor
<b>Aim:</b> The aim of the study was to determine the success of autogenous vaccine application in treatment of TVT.<p> <b>Materials and Methods:</b> The study was conducted on 8 bitches with TVT. . The autogenous vaccine applied on the dogs was maddened the based on th...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
|
| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=974 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | <b>Aim:</b> The aim of the study was to determine the success of
autogenous vaccine application in treatment of TVT.<p>
<b>Materials and Methods:</b> The study was conducted on 8
bitches with TVT. . The autogenous vaccine applied on the
dogs was maddened the based on the bovine papillomatosis
vaccine. Approximately 24 g of tumor tissue and 48 mL
Tris buffer (pH 7.5) solution were crushed in cold conditions
(+4 0C) during 15-20 minutes in mortar disintegrated
with autoclaved sterile sand. Half of the mixture (36 mL)
was completed with tris buffer to 60-65 mL. 0.5 percent formalin
was added this mixture and mixture was portioned to
6 each has 10 mL. The prepared vaccine was administered
4 times (SC) with an interval of 1 week. Dogs were followed
up 3 months after 4th application and evaluations were performed
for tumor regression.<p>
<b>Results:</b> Serosanguineous or hemorrhagic genital discharge
was determined in dogs prior to application of autogenous
vaccine. The lesions in external genital organs are
like cauliflower, rubescent, fresh-looking and easily bleed
on touched. After administration of the autogenous vaccine,
serosanguineous or hemorrhagic genital discharge from
the masses on the external genital organs of dogs continued,
and there were no changes in the mass fragility. After
the application of autogenous vaccines at four times, there
was no any decline and improvement in the masses on the
vagina and vulva.<p>
<b>Conclusions:</b> It is believed that a viral agent may contribute
to the etiology of TVT. Prepared autogenous vaccine
technique used in the treatment of bovine papillomatosis
derived from bovine papilloma virus may not be suitable in
the treatment of bitches with TVT. |
|---|---|
| ISSN: | 1309-6958 2146-1953 |