Intrinsic Apoptosis Pathway in Fallopian Tube Epithelial Cells Induced by Cladribine
Cladribine is a purine nucleoside analog which initiates the apoptotic mechanism within cells. Moreover, the available data confirms that cladribine, with the participation of the p53 protein, as well as the proapoptotic proteins from the Bcl-2 family, also induces the activation of the intrinsic ap...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/928036 |
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| author | Ewelina Wawryk-Gawda Patrycja Chylińska-Wrzos Marta Lis-Sochocka Kamila Bulak Barbara Jodłowska-Jędrych |
| author_facet | Ewelina Wawryk-Gawda Patrycja Chylińska-Wrzos Marta Lis-Sochocka Kamila Bulak Barbara Jodłowska-Jędrych |
| author_sort | Ewelina Wawryk-Gawda |
| collection | DOAJ |
| description | Cladribine is a purine nucleoside analog which initiates the apoptotic mechanism within cells. Moreover, the available data confirms that cladribine, with the participation of the p53 protein, as well as the proapoptotic proteins from the Bcl-2 family, also induces the activation of the intrinsic apoptosis pathway. However, while there has been a lot of research devoted to the effect of cladribine on lymphatic system cells, little is known about the impact of cladribine on the reproductive system. The aim of our study was to evaluate apoptosis in oviduct epithelial cells sourced from 15 different female rats. In so doing, the sections were stained with caspases 3, 9, and 8. Results suggest that cladribine also induces apoptosis in the oviduct epithelial cells by way of the intrinsic pathway. Indeed, the discontinuing of the administration of cladribine leads to a reduction in the amount of apoptotic cells in the oviduct epithelium. |
| format | Article |
| id | doaj-art-ae28a520d3864110b16f6feea526f454 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-ae28a520d3864110b16f6feea526f4542025-02-03T01:26:16ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/928036928036Intrinsic Apoptosis Pathway in Fallopian Tube Epithelial Cells Induced by CladribineEwelina Wawryk-Gawda0Patrycja Chylińska-Wrzos1Marta Lis-Sochocka2Kamila Bulak3Barbara Jodłowska-Jędrych4Chair and Department of Histology and Embryology with Experimental Cytology Unit, Medical University of Lublin, Radziwiłłowska 11 Street, 20-080 Lublin, PolandChair and Department of Histology and Embryology with Experimental Cytology Unit, Medical University of Lublin, Radziwiłłowska 11 Street, 20-080 Lublin, PolandChair and Department of Histology and Embryology with Experimental Cytology Unit, Medical University of Lublin, Radziwiłłowska 11 Street, 20-080 Lublin, PolandChair and Department of Histology and Embryology with Experimental Cytology Unit, Medical University of Lublin, Radziwiłłowska 11 Street, 20-080 Lublin, PolandChair and Department of Histology and Embryology with Experimental Cytology Unit, Medical University of Lublin, Radziwiłłowska 11 Street, 20-080 Lublin, PolandCladribine is a purine nucleoside analog which initiates the apoptotic mechanism within cells. Moreover, the available data confirms that cladribine, with the participation of the p53 protein, as well as the proapoptotic proteins from the Bcl-2 family, also induces the activation of the intrinsic apoptosis pathway. However, while there has been a lot of research devoted to the effect of cladribine on lymphatic system cells, little is known about the impact of cladribine on the reproductive system. The aim of our study was to evaluate apoptosis in oviduct epithelial cells sourced from 15 different female rats. In so doing, the sections were stained with caspases 3, 9, and 8. Results suggest that cladribine also induces apoptosis in the oviduct epithelial cells by way of the intrinsic pathway. Indeed, the discontinuing of the administration of cladribine leads to a reduction in the amount of apoptotic cells in the oviduct epithelium.http://dx.doi.org/10.1155/2014/928036 |
| spellingShingle | Ewelina Wawryk-Gawda Patrycja Chylińska-Wrzos Marta Lis-Sochocka Kamila Bulak Barbara Jodłowska-Jędrych Intrinsic Apoptosis Pathway in Fallopian Tube Epithelial Cells Induced by Cladribine The Scientific World Journal |
| title | Intrinsic Apoptosis Pathway in Fallopian Tube Epithelial Cells Induced by Cladribine |
| title_full | Intrinsic Apoptosis Pathway in Fallopian Tube Epithelial Cells Induced by Cladribine |
| title_fullStr | Intrinsic Apoptosis Pathway in Fallopian Tube Epithelial Cells Induced by Cladribine |
| title_full_unstemmed | Intrinsic Apoptosis Pathway in Fallopian Tube Epithelial Cells Induced by Cladribine |
| title_short | Intrinsic Apoptosis Pathway in Fallopian Tube Epithelial Cells Induced by Cladribine |
| title_sort | intrinsic apoptosis pathway in fallopian tube epithelial cells induced by cladribine |
| url | http://dx.doi.org/10.1155/2014/928036 |
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