Visual-Evoked-Response-Supported Outcome of Intravitreal Erythropoietin in Management of Indirect Traumatic Optic Neuropathy
Purpose. Investigating the efficacy of intravitreal injection of erythropoietin (EPO) in managing indirect traumatic optic neuropathy (ITON) of different durations. Methods. A case series that included two groups of ITON patients: recent ITON group (<3 months trauma duration; 7 eyes) and old dura...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2018/2750632 |
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| author | Mohammad Ahmad Rashad Ahmed Abdel Meguid Abdel Latif Hazem A. Mostafa Samah Mahmoud Fawzy Mahmoud Abdel Meguid Abdel Latif |
| author_facet | Mohammad Ahmad Rashad Ahmed Abdel Meguid Abdel Latif Hazem A. Mostafa Samah Mahmoud Fawzy Mahmoud Abdel Meguid Abdel Latif |
| author_sort | Mohammad Ahmad Rashad |
| collection | DOAJ |
| description | Purpose. Investigating the efficacy of intravitreal injection of erythropoietin (EPO) in managing indirect traumatic optic neuropathy (ITON) of different durations. Methods. A case series that included two groups of ITON patients: recent ITON group (<3 months trauma duration; 7 eyes) and old duration ITON group (3–36 months; 7 eyes). Diagnostic computerized tomography (CT) and baseline flash visual evoked response (VER) were performed at the presentation time. At the initial visit and each follow-up, all patients had undergone assessment of best-corrected visual acuity (BCVA), pupil reaction, and anterior and posterior segments. VER was repeated 1 and 3 months after injection. All patients received an intravitreal injection of 2000 IU EPO in 0.2 ml of commercially available sterile EPREX 4000 solution, Jansen Cilag, Zug, Switzerland. Five patients had received a second injection 3 months later. Results. Significant improvement was found in BCVA, VER amplitude, and latency (P<0.0001, 0.0154, and 0.0291, respectively). Initial values of BCVA, VER amplitude, and latency correlated significantly to the final values. Differences between recent and old trauma groups were insignificant in the three parameters. In patients who received second injection, further clinical but statistically insignificant improvement was noted in BCVA in 60% of patients, VER amplitude in 50% of patients, and in VER latency in 100% of patients. No complications were recorded. Conclusion. Intravitreal injection of EPO may be effective and safe in treatment of recent and old indirect traumatic optic neuropathy. |
| format | Article |
| id | doaj-art-ae2431e5f95342789eb9eb4a10af5192 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-ae2431e5f95342789eb9eb4a10af51922025-02-03T01:11:38ZengWileyJournal of Ophthalmology2090-004X2090-00582018-01-01201810.1155/2018/27506322750632Visual-Evoked-Response-Supported Outcome of Intravitreal Erythropoietin in Management of Indirect Traumatic Optic NeuropathyMohammad Ahmad Rashad0Ahmed Abdel Meguid Abdel Latif1Hazem A. Mostafa2Samah Mahmoud Fawzy3Mahmoud Abdel Meguid Abdel Latif4Ain Shams University, Faculty of Medicine, Ophthalmology Department, Cairo, EgyptAin Shams University, Faculty of Medicine, Ophthalmology Department, Cairo, EgyptAin Shams University, Faculty of Medicine, Neurosurgery Department, Cairo, EgyptAin Shams University, Faculty of Medicine, Ophthalmology Department, Cairo, EgyptAin Shams University, Faculty of Medicine, Ophthalmology Department, Cairo, EgyptPurpose. Investigating the efficacy of intravitreal injection of erythropoietin (EPO) in managing indirect traumatic optic neuropathy (ITON) of different durations. Methods. A case series that included two groups of ITON patients: recent ITON group (<3 months trauma duration; 7 eyes) and old duration ITON group (3–36 months; 7 eyes). Diagnostic computerized tomography (CT) and baseline flash visual evoked response (VER) were performed at the presentation time. At the initial visit and each follow-up, all patients had undergone assessment of best-corrected visual acuity (BCVA), pupil reaction, and anterior and posterior segments. VER was repeated 1 and 3 months after injection. All patients received an intravitreal injection of 2000 IU EPO in 0.2 ml of commercially available sterile EPREX 4000 solution, Jansen Cilag, Zug, Switzerland. Five patients had received a second injection 3 months later. Results. Significant improvement was found in BCVA, VER amplitude, and latency (P<0.0001, 0.0154, and 0.0291, respectively). Initial values of BCVA, VER amplitude, and latency correlated significantly to the final values. Differences between recent and old trauma groups were insignificant in the three parameters. In patients who received second injection, further clinical but statistically insignificant improvement was noted in BCVA in 60% of patients, VER amplitude in 50% of patients, and in VER latency in 100% of patients. No complications were recorded. Conclusion. Intravitreal injection of EPO may be effective and safe in treatment of recent and old indirect traumatic optic neuropathy.http://dx.doi.org/10.1155/2018/2750632 |
| spellingShingle | Mohammad Ahmad Rashad Ahmed Abdel Meguid Abdel Latif Hazem A. Mostafa Samah Mahmoud Fawzy Mahmoud Abdel Meguid Abdel Latif Visual-Evoked-Response-Supported Outcome of Intravitreal Erythropoietin in Management of Indirect Traumatic Optic Neuropathy Journal of Ophthalmology |
| title | Visual-Evoked-Response-Supported Outcome of Intravitreal Erythropoietin in Management of Indirect Traumatic Optic Neuropathy |
| title_full | Visual-Evoked-Response-Supported Outcome of Intravitreal Erythropoietin in Management of Indirect Traumatic Optic Neuropathy |
| title_fullStr | Visual-Evoked-Response-Supported Outcome of Intravitreal Erythropoietin in Management of Indirect Traumatic Optic Neuropathy |
| title_full_unstemmed | Visual-Evoked-Response-Supported Outcome of Intravitreal Erythropoietin in Management of Indirect Traumatic Optic Neuropathy |
| title_short | Visual-Evoked-Response-Supported Outcome of Intravitreal Erythropoietin in Management of Indirect Traumatic Optic Neuropathy |
| title_sort | visual evoked response supported outcome of intravitreal erythropoietin in management of indirect traumatic optic neuropathy |
| url | http://dx.doi.org/10.1155/2018/2750632 |
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