Turnover of Focal Adhesions and Cancer Cell Migration
Cells are usually surrounded by the extracellular matrix (ECM), and adhesion of the cells to the ECM is a key step in their migration through tissues. Integrins are important receptors for the ECM and form structures called focal adhesions (FAs). Formation and disassembly of FAs are regulated dynami...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/310616 |
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| _version_ | 1832553417712599040 |
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| author | Makoto Nagano Daisuke Hoshino Naohiko Koshikawa Toshifumi Akizawa Motoharu Seiki |
| author_facet | Makoto Nagano Daisuke Hoshino Naohiko Koshikawa Toshifumi Akizawa Motoharu Seiki |
| author_sort | Makoto Nagano |
| collection | DOAJ |
| description | Cells are usually surrounded by the extracellular matrix (ECM), and adhesion of the cells to the ECM is a key step in their migration through tissues. Integrins are important receptors for the ECM and form structures called focal adhesions (FAs). Formation and disassembly of FAs are regulated dynamically during cell migration. Adhesion to the ECM has been studied mainly using cells cultured on an ECM-coated substratum, where the rate of cell migration is determined by the turnover of FAs. However, the molecular events underlying the disassembly of FAs are less well understood. We have recently identified both a new regulator of this disassembly process and its interaction partners. Here, we summarize our understanding of FA disassembly by focusing on the proteins implicated in this process. |
| format | Article |
| id | doaj-art-ae1b482b30d74bfbb097da15480ee861 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-ae1b482b30d74bfbb097da15480ee8612025-02-03T05:54:05ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/310616310616Turnover of Focal Adhesions and Cancer Cell MigrationMakoto Nagano0Daisuke Hoshino1Naohiko Koshikawa2Toshifumi Akizawa3Motoharu Seiki4Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, JapanDivision of Cancer Cell Research, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokane-dai, Minato-ku, Tokyo 108-8639, JapanDivision of Cancer Cell Research, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokane-dai, Minato-ku, Tokyo 108-8639, JapanFaculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, JapanDivision of Cancer Cell Research, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokane-dai, Minato-ku, Tokyo 108-8639, JapanCells are usually surrounded by the extracellular matrix (ECM), and adhesion of the cells to the ECM is a key step in their migration through tissues. Integrins are important receptors for the ECM and form structures called focal adhesions (FAs). Formation and disassembly of FAs are regulated dynamically during cell migration. Adhesion to the ECM has been studied mainly using cells cultured on an ECM-coated substratum, where the rate of cell migration is determined by the turnover of FAs. However, the molecular events underlying the disassembly of FAs are less well understood. We have recently identified both a new regulator of this disassembly process and its interaction partners. Here, we summarize our understanding of FA disassembly by focusing on the proteins implicated in this process.http://dx.doi.org/10.1155/2012/310616 |
| spellingShingle | Makoto Nagano Daisuke Hoshino Naohiko Koshikawa Toshifumi Akizawa Motoharu Seiki Turnover of Focal Adhesions and Cancer Cell Migration International Journal of Cell Biology |
| title | Turnover of Focal Adhesions and Cancer Cell Migration |
| title_full | Turnover of Focal Adhesions and Cancer Cell Migration |
| title_fullStr | Turnover of Focal Adhesions and Cancer Cell Migration |
| title_full_unstemmed | Turnover of Focal Adhesions and Cancer Cell Migration |
| title_short | Turnover of Focal Adhesions and Cancer Cell Migration |
| title_sort | turnover of focal adhesions and cancer cell migration |
| url | http://dx.doi.org/10.1155/2012/310616 |
| work_keys_str_mv | AT makotonagano turnoveroffocaladhesionsandcancercellmigration AT daisukehoshino turnoveroffocaladhesionsandcancercellmigration AT naohikokoshikawa turnoveroffocaladhesionsandcancercellmigration AT toshifumiakizawa turnoveroffocaladhesionsandcancercellmigration AT motoharuseiki turnoveroffocaladhesionsandcancercellmigration |