Dual-energy CT-derived virtual noncalcium imaging to assess bone marrow lesions in patients with knee osteoarthritis
Abstract To determine the diagnostic performance of dual-energy CT (DECT) virtual noncalcium (VNCa) technique in the detection of bone marrow lesions (BMLs) in knee osteoarthritis, and further analyze the correlation between the severity of BMLs on VNCa image and the degree of knee pain. 23 consecut...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-86697-2 |
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| author | Wei Chen Limin Liu Heng Zhao Hui Li Jing Luo Yao-lin Qu Dan Zhang Ya-han He Yi-sha Pan Fang Gao Hua-zhi Liao Xiao-long Chen Hao Lei De-qiu Tang Fei Peng |
| author_facet | Wei Chen Limin Liu Heng Zhao Hui Li Jing Luo Yao-lin Qu Dan Zhang Ya-han He Yi-sha Pan Fang Gao Hua-zhi Liao Xiao-long Chen Hao Lei De-qiu Tang Fei Peng |
| author_sort | Wei Chen |
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| description | Abstract To determine the diagnostic performance of dual-energy CT (DECT) virtual noncalcium (VNCa) technique in the detection of bone marrow lesions (BMLs) in knee osteoarthritis, and further analyze the correlation between the severity of BMLs on VNCa image and the degree of knee pain. 23 consecutive patients with clinically diagnosed knee osteoarthritis were underwent DECT and 3.0T MRI between August 2017 and November 2018. Evaluation of two pain assessment scales (WOMAC and KOOS) were collected. VNCa images and MRI were independently scored by three readers using a four-level scoring system over 15 anatomical subregions in each knee joint. Spearman correlation coefficient was used for total BML scores on DECT and MRI correlation with WOMAC and KOOS. Specificity, Sensitivity, NPV and PPV of reader 1 and reader 2 were 99.4%/99.2%, 89.4%/87.2%, 98.6%/98.3% and 95.5%/93.2%. A cutoff value of − 41.5 HU/− 46.5 HU provided sensitivities of 93.2%/90.9% and specificities of 100.0%/93.9% for diagnosing BMLs with AUC of 0.970/0.996. A stronger correlation was observed between the WOMAC and total BML score compared to the KOOS. DECT possessed excellent diagnostic performance in the detection of BMLs in knee osteoarthritis. And the pain degree increased with the severity of BMLs on VNCa images. |
| format | Article |
| id | doaj-art-ae1a72e70b014c1fad6effc38d2b2e04 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-ae1a72e70b014c1fad6effc38d2b2e042025-02-02T12:19:10ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-025-86697-2Dual-energy CT-derived virtual noncalcium imaging to assess bone marrow lesions in patients with knee osteoarthritisWei Chen0Limin Liu1Heng Zhao2Hui Li3Jing Luo4Yao-lin Qu5Dan Zhang6Ya-han He7Yi-sha Pan8Fang Gao9Hua-zhi Liao10Xiao-long Chen11Hao Lei12De-qiu Tang13Fei Peng14Department of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South ChinaDepartment of Ultrasound, The Second Affiliated Hospital, Hengyang Medical School, University of South ChinaDepartment of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South ChinaDepartment of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South ChinaDepartment of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South ChinaDepartment of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South ChinaDepartment of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South ChinaDepartment of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South ChinaDepartment of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South ChinaDepartment of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South ChinaDepartment of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South ChinaDepartment of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South ChinaDepartment of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South ChinaDepartment of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South ChinaDepartment of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South ChinaAbstract To determine the diagnostic performance of dual-energy CT (DECT) virtual noncalcium (VNCa) technique in the detection of bone marrow lesions (BMLs) in knee osteoarthritis, and further analyze the correlation between the severity of BMLs on VNCa image and the degree of knee pain. 23 consecutive patients with clinically diagnosed knee osteoarthritis were underwent DECT and 3.0T MRI between August 2017 and November 2018. Evaluation of two pain assessment scales (WOMAC and KOOS) were collected. VNCa images and MRI were independently scored by three readers using a four-level scoring system over 15 anatomical subregions in each knee joint. Spearman correlation coefficient was used for total BML scores on DECT and MRI correlation with WOMAC and KOOS. Specificity, Sensitivity, NPV and PPV of reader 1 and reader 2 were 99.4%/99.2%, 89.4%/87.2%, 98.6%/98.3% and 95.5%/93.2%. A cutoff value of − 41.5 HU/− 46.5 HU provided sensitivities of 93.2%/90.9% and specificities of 100.0%/93.9% for diagnosing BMLs with AUC of 0.970/0.996. A stronger correlation was observed between the WOMAC and total BML score compared to the KOOS. DECT possessed excellent diagnostic performance in the detection of BMLs in knee osteoarthritis. And the pain degree increased with the severity of BMLs on VNCa images.https://doi.org/10.1038/s41598-025-86697-2Bone marrow lesionPainKnee osteoarthritisDual-energy CTVirtual noncalcium |
| spellingShingle | Wei Chen Limin Liu Heng Zhao Hui Li Jing Luo Yao-lin Qu Dan Zhang Ya-han He Yi-sha Pan Fang Gao Hua-zhi Liao Xiao-long Chen Hao Lei De-qiu Tang Fei Peng Dual-energy CT-derived virtual noncalcium imaging to assess bone marrow lesions in patients with knee osteoarthritis Scientific Reports Bone marrow lesion Pain Knee osteoarthritis Dual-energy CT Virtual noncalcium |
| title | Dual-energy CT-derived virtual noncalcium imaging to assess bone marrow lesions in patients with knee osteoarthritis |
| title_full | Dual-energy CT-derived virtual noncalcium imaging to assess bone marrow lesions in patients with knee osteoarthritis |
| title_fullStr | Dual-energy CT-derived virtual noncalcium imaging to assess bone marrow lesions in patients with knee osteoarthritis |
| title_full_unstemmed | Dual-energy CT-derived virtual noncalcium imaging to assess bone marrow lesions in patients with knee osteoarthritis |
| title_short | Dual-energy CT-derived virtual noncalcium imaging to assess bone marrow lesions in patients with knee osteoarthritis |
| title_sort | dual energy ct derived virtual noncalcium imaging to assess bone marrow lesions in patients with knee osteoarthritis |
| topic | Bone marrow lesion Pain Knee osteoarthritis Dual-energy CT Virtual noncalcium |
| url | https://doi.org/10.1038/s41598-025-86697-2 |
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