An Overview of Pathogen Recognition Receptors for Innate Immunity in Dental Pulp
Pathogen recognition receptors (PRRs) are a class of germ line-encoded receptors that recognize pathogen-associated molecular patterns (PAMPs). The activation of PRRs is crucial for the initiation of innate immunity, which plays a key role in first-line defense until more specific adaptive immunity...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/794143 |
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| _version_ | 1832566563678453760 |
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| author | Ji-Hyun Jang Hee Woong Shin Jung Min Lee Hyeon-Woo Lee Eun-Cheol Kim Sang Hyuk Park |
| author_facet | Ji-Hyun Jang Hee Woong Shin Jung Min Lee Hyeon-Woo Lee Eun-Cheol Kim Sang Hyuk Park |
| author_sort | Ji-Hyun Jang |
| collection | DOAJ |
| description | Pathogen recognition receptors (PRRs) are a class of germ line-encoded receptors that recognize pathogen-associated molecular patterns (PAMPs). The activation of PRRs is crucial for the initiation of innate immunity, which plays a key role in first-line defense until more specific adaptive immunity is developed. PRRs differ in the signaling cascades and host responses activated by their engagement and in their tissue distribution. Currently identified PRR families are the Toll-like receptors (TLRs), the C-type lectin receptors (CLRs), the nucleotide-binding oligomerization domain-like receptors (NLRs), the retinoic acid-inducible gene-I-like receptors (RLRs), and the AIM2-like receptor (ALR). The environment of the dental pulp is substantially different from that of other tissues of the body. Dental pulp resides in a low compliance root canal system that limits the expansion of pulpal tissues during inflammatory processes. An understanding of the PRRs in dental pulp is important for immunomodulation and hence for developing therapeutic targets in the field of endodontics. Here we comprehensively review recent finding on the PRRs and the mechanisms by which innate immunity is activated. We focus on the PRRs expressed on dental pulp and periapical tissues and their role in dental pulp inflammation. |
| format | Article |
| id | doaj-art-ae133d9f65074bbe8874e22083e4af3f |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-ae133d9f65074bbe8874e22083e4af3f2025-02-03T01:03:44ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/794143794143An Overview of Pathogen Recognition Receptors for Innate Immunity in Dental PulpJi-Hyun Jang0Hee Woong Shin1Jung Min Lee2Hyeon-Woo Lee3Eun-Cheol Kim4Sang Hyuk Park5Department of Conservative Dentistry, Kyung Hee University Dental Hospital at Gangdong, Seoul, Republic of KoreaSchool of Dentistry, University of Western Australia, Nedlands, WA, AustraliaDepartment of Conservative Dentistry, Graduate School, Kyung Hee University, Seoul, Republic of KoreaDepartment of Pharmacology, School of Dentistry, Kyung Hee University, Seoul, Republic of KoreaOral Biology Research Institute, School of Dentistry, Kyung Hee University, Seoul, Republic of KoreaDepartment of Conservative Dentistry, Kyung Hee University Dental Hospital at Gangdong, Seoul, Republic of KoreaPathogen recognition receptors (PRRs) are a class of germ line-encoded receptors that recognize pathogen-associated molecular patterns (PAMPs). The activation of PRRs is crucial for the initiation of innate immunity, which plays a key role in first-line defense until more specific adaptive immunity is developed. PRRs differ in the signaling cascades and host responses activated by their engagement and in their tissue distribution. Currently identified PRR families are the Toll-like receptors (TLRs), the C-type lectin receptors (CLRs), the nucleotide-binding oligomerization domain-like receptors (NLRs), the retinoic acid-inducible gene-I-like receptors (RLRs), and the AIM2-like receptor (ALR). The environment of the dental pulp is substantially different from that of other tissues of the body. Dental pulp resides in a low compliance root canal system that limits the expansion of pulpal tissues during inflammatory processes. An understanding of the PRRs in dental pulp is important for immunomodulation and hence for developing therapeutic targets in the field of endodontics. Here we comprehensively review recent finding on the PRRs and the mechanisms by which innate immunity is activated. We focus on the PRRs expressed on dental pulp and periapical tissues and their role in dental pulp inflammation.http://dx.doi.org/10.1155/2015/794143 |
| spellingShingle | Ji-Hyun Jang Hee Woong Shin Jung Min Lee Hyeon-Woo Lee Eun-Cheol Kim Sang Hyuk Park An Overview of Pathogen Recognition Receptors for Innate Immunity in Dental Pulp Mediators of Inflammation |
| title | An Overview of Pathogen Recognition Receptors for Innate Immunity in Dental Pulp |
| title_full | An Overview of Pathogen Recognition Receptors for Innate Immunity in Dental Pulp |
| title_fullStr | An Overview of Pathogen Recognition Receptors for Innate Immunity in Dental Pulp |
| title_full_unstemmed | An Overview of Pathogen Recognition Receptors for Innate Immunity in Dental Pulp |
| title_short | An Overview of Pathogen Recognition Receptors for Innate Immunity in Dental Pulp |
| title_sort | overview of pathogen recognition receptors for innate immunity in dental pulp |
| url | http://dx.doi.org/10.1155/2015/794143 |
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