An in vivo intermediate filament assembly model
A model is developed to study the in vivo intermediate filament organization in terms of repartition between four different structural states: soluble proteins, particles, short, and long filaments. An analysis is conducted, showing that the system has a unique, globally asymptotically stable equili...
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| Format: | Article |
| Language: | English |
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AIMS Press
2008-11-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2009.6.117 |
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| _version_ | 1832590206702714880 |
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| author | Stéphanie Portet Julien Arino |
| author_facet | Stéphanie Portet Julien Arino |
| author_sort | Stéphanie Portet |
| collection | DOAJ |
| description | A model is developed to study the in vivo intermediate filament organization in terms of repartition between four different structural states: soluble proteins, particles, short, and long filaments. An analysis is conducted, showing that the system has a unique, globally asymptotically stable equilibrium. By means of sensitivity analysis, the influence of parameters on the system is studied. It is shown that, in agreement with biological observations, posttranslational modifications of intermediate filament proteins resulting in filament solubilization are the main regulators of the intermediate filament organization. A high signalling-dependent solubilization of filaments favours the intermediate filament aggregation in particles. |
| format | Article |
| id | doaj-art-ae11e990d02b4e2ba2cea9275d575525 |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2008-11-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-ae11e990d02b4e2ba2cea9275d5755252025-01-24T01:58:53ZengAIMS PressMathematical Biosciences and Engineering1551-00182008-11-016111713410.3934/mbe.2009.6.117An in vivo intermediate filament assembly modelStéphanie Portet0Julien Arino1Department of Mathematics, University of Manitoba, Winnipeg, MBDepartment of Mathematics, University of Manitoba, Winnipeg, MBA model is developed to study the in vivo intermediate filament organization in terms of repartition between four different structural states: soluble proteins, particles, short, and long filaments. An analysis is conducted, showing that the system has a unique, globally asymptotically stable equilibrium. By means of sensitivity analysis, the influence of parameters on the system is studied. It is shown that, in agreement with biological observations, posttranslational modifications of intermediate filament proteins resulting in filament solubilization are the main regulators of the intermediate filament organization. A high signalling-dependent solubilization of filaments favours the intermediate filament aggregation in particles.https://www.aimspress.com/article/doi/10.3934/mbe.2009.6.117cytoskeleton assembly dynamicsintermediate filaments |
| spellingShingle | Stéphanie Portet Julien Arino An in vivo intermediate filament assembly model Mathematical Biosciences and Engineering cytoskeleton assembly dynamics intermediate filaments |
| title | An in vivo intermediate filament assembly model |
| title_full | An in vivo intermediate filament assembly model |
| title_fullStr | An in vivo intermediate filament assembly model |
| title_full_unstemmed | An in vivo intermediate filament assembly model |
| title_short | An in vivo intermediate filament assembly model |
| title_sort | in vivo intermediate filament assembly model |
| topic | cytoskeleton assembly dynamics intermediate filaments |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2009.6.117 |
| work_keys_str_mv | AT stephanieportet aninvivointermediatefilamentassemblymodel AT julienarino aninvivointermediatefilamentassemblymodel AT stephanieportet invivointermediatefilamentassemblymodel AT julienarino invivointermediatefilamentassemblymodel |