Promyelocytic Sarcoma of the Spine: A Case Report and Review of the Literature
Myeloid sarcoma (MS, previously named granulocytic sarcoma or chloroma) is a rare extramedullary tumour of immature myeloid cells. It can be present before, concurrently with, or after the diagnosis of acute myeloid leukemia. MS is extremely uncommon in acute promyelocytic leukemia (APL). In the cas...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2010/137608 |
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| author | Leonardo Pacilli Francesco Lo Coco Safaa Mahmoud Ramadan Laura Giannì Alberto Pingi Daniele Remotti Ignazio Majolino |
| author_facet | Leonardo Pacilli Francesco Lo Coco Safaa Mahmoud Ramadan Laura Giannì Alberto Pingi Daniele Remotti Ignazio Majolino |
| author_sort | Leonardo Pacilli |
| collection | DOAJ |
| description | Myeloid sarcoma (MS, previously named granulocytic sarcoma or chloroma) is a rare extramedullary tumour of immature myeloid cells. It can be present before, concurrently with, or after the diagnosis of acute myeloid leukemia. MS is extremely uncommon in acute promyelocytic leukemia (APL). In the case described here, MS was the sole site of APL relapse and the cause of spinal cord compression. The patient presented with neurologic symptoms due to a paravertebral mass of MS after 7 years of complete remission. He was treated with excision of the mass followed by local radiotherapy. Systemic treatment was also given with combined arsenic trioxide and all-trans retinoic acid and the patient was able to achieve a second prolonged clinical and molecular remission. |
| format | Article |
| id | doaj-art-ae0a14c271eb4d5f92c219cbb0f0beb5 |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-ae0a14c271eb4d5f92c219cbb0f0beb52025-02-03T01:06:13ZengWileyAdvances in Hematology1687-91041687-91122010-01-01201010.1155/2010/137608137608Promyelocytic Sarcoma of the Spine: A Case Report and Review of the LiteratureLeonardo Pacilli0Francesco Lo Coco1Safaa Mahmoud Ramadan2Laura Giannì3Alberto Pingi4Daniele Remotti5Ignazio Majolino6Hematology and BMT Unit, Institute of Hematotherapy, Ospedale S. Camillo, 00153 Rome, ItalyDepartment of Biopathology, Tor Vergata University, 00133 Rome, ItalyDepartment of Biopathology, Tor Vergata University, 00133 Rome, ItalyDepartment of Biopathology, Tor Vergata University, 00133 Rome, ItalyHematology and BMT Unit, Institute of Hematotherapy, Ospedale S. Camillo, 00153 Rome, ItalyHematology and BMT Unit, Institute of Hematotherapy, Ospedale S. Camillo, 00153 Rome, ItalyHematology and BMT Unit, Institute of Hematotherapy, Ospedale S. Camillo, 00153 Rome, ItalyMyeloid sarcoma (MS, previously named granulocytic sarcoma or chloroma) is a rare extramedullary tumour of immature myeloid cells. It can be present before, concurrently with, or after the diagnosis of acute myeloid leukemia. MS is extremely uncommon in acute promyelocytic leukemia (APL). In the case described here, MS was the sole site of APL relapse and the cause of spinal cord compression. The patient presented with neurologic symptoms due to a paravertebral mass of MS after 7 years of complete remission. He was treated with excision of the mass followed by local radiotherapy. Systemic treatment was also given with combined arsenic trioxide and all-trans retinoic acid and the patient was able to achieve a second prolonged clinical and molecular remission.http://dx.doi.org/10.1155/2010/137608 |
| spellingShingle | Leonardo Pacilli Francesco Lo Coco Safaa Mahmoud Ramadan Laura Giannì Alberto Pingi Daniele Remotti Ignazio Majolino Promyelocytic Sarcoma of the Spine: A Case Report and Review of the Literature Advances in Hematology |
| title | Promyelocytic Sarcoma of the Spine: A Case Report and Review of
the Literature |
| title_full | Promyelocytic Sarcoma of the Spine: A Case Report and Review of
the Literature |
| title_fullStr | Promyelocytic Sarcoma of the Spine: A Case Report and Review of
the Literature |
| title_full_unstemmed | Promyelocytic Sarcoma of the Spine: A Case Report and Review of
the Literature |
| title_short | Promyelocytic Sarcoma of the Spine: A Case Report and Review of
the Literature |
| title_sort | promyelocytic sarcoma of the spine a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2010/137608 |
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