Associations between neutrophil percentage to albumin ratio and rheumatoid arthritis versus osteoarthritis: a comprehensive analysis utilizing the NHANES database
ObjectivesThe association between the neutrophil percentage to albumin ratio (NPAR) and the risk of osteoarthritis (OA) and rheumatoid arthritis (RA) remains unclear. This study aims to investigate the association between NPAR and the risk of OA and RA.MethodsThis cross-sectional study analyzed data...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1436311/full |
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| author | Wenquan Ding Rui La Shenghao Wang Zhiyuan He Dinghua Jiang Zhigang Zhang Hao Ni Wu Xu Lixin Huang Qian Wu Qian Wu |
| author_facet | Wenquan Ding Rui La Shenghao Wang Zhiyuan He Dinghua Jiang Zhigang Zhang Hao Ni Wu Xu Lixin Huang Qian Wu Qian Wu |
| author_sort | Wenquan Ding |
| collection | DOAJ |
| description | ObjectivesThe association between the neutrophil percentage to albumin ratio (NPAR) and the risk of osteoarthritis (OA) and rheumatoid arthritis (RA) remains unclear. This study aims to investigate the association between NPAR and the risk of OA and RA.MethodsThis cross-sectional study analyzed data from 92,062 American adults in the NHANES database between 1999 and 2016. Various statistical analyses were conducted to investigate the associations between NPAR and the risks of OA and RA, including multivariable logistic regression, subgroup analysis, smooth curve fitting, and threshold effect analysis.ResultsAfter screening, the final study population included 36,147 participants, with 3,881 individuals diagnosed with OA and 2,178 with RA. After adjusting for confounding factors, higher NPAR levels were associated with an increased risk of RA (OR=1.05; 95% CI: 1.03-1.07; P <0.0001), but not with OA (OR=1.01; 95% CI: 0.99-1.02; P =0.755). This association was remarkably consistent across subgroups by age, sex, body mass index (BMI), alcohol consumption, hypertension, diabetes, and smoking status. Further analyses using curve fitting and threshold effect models revealed a nonlinear association between NPAR and RA, with an inflection point identified at 15.56.ConclusionHigh levels of NPAR is positively associated with the prevalence of RA. This provides us with new insights for the management and treatment of RA patients. |
| format | Article |
| id | doaj-art-ae076c57c8874f63918858bbaeb0eeb5 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-ae076c57c8874f63918858bbaeb0eeb52025-01-23T06:56:29ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011610.3389/fimmu.2025.14363111436311Associations between neutrophil percentage to albumin ratio and rheumatoid arthritis versus osteoarthritis: a comprehensive analysis utilizing the NHANES databaseWenquan Ding0Rui La1Shenghao Wang2Zhiyuan He3Dinghua Jiang4Zhigang Zhang5Hao Ni6Wu Xu7Lixin Huang8Qian Wu9Qian Wu10Department of Orthopedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu, ChinaDepartment of Orthopedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu, ChinaDepartment of Orthopedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu, ChinaDepartment of Orthopedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu, ChinaDepartment of Orthopedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu, ChinaDepartment of Orthopedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu, ChinaDepartment of Pathology, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu, ChinaDepartment of Orthopedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu, ChinaDepartment of Orthopedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu, ChinaDepartment of Orthopedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, Soochow, Jiangsu, ChinaResearch Institute of Clinical Medicine, Jeonbuk National University Medical School, Jeonju, Republic of KoreaObjectivesThe association between the neutrophil percentage to albumin ratio (NPAR) and the risk of osteoarthritis (OA) and rheumatoid arthritis (RA) remains unclear. This study aims to investigate the association between NPAR and the risk of OA and RA.MethodsThis cross-sectional study analyzed data from 92,062 American adults in the NHANES database between 1999 and 2016. Various statistical analyses were conducted to investigate the associations between NPAR and the risks of OA and RA, including multivariable logistic regression, subgroup analysis, smooth curve fitting, and threshold effect analysis.ResultsAfter screening, the final study population included 36,147 participants, with 3,881 individuals diagnosed with OA and 2,178 with RA. After adjusting for confounding factors, higher NPAR levels were associated with an increased risk of RA (OR=1.05; 95% CI: 1.03-1.07; P <0.0001), but not with OA (OR=1.01; 95% CI: 0.99-1.02; P =0.755). This association was remarkably consistent across subgroups by age, sex, body mass index (BMI), alcohol consumption, hypertension, diabetes, and smoking status. Further analyses using curve fitting and threshold effect models revealed a nonlinear association between NPAR and RA, with an inflection point identified at 15.56.ConclusionHigh levels of NPAR is positively associated with the prevalence of RA. This provides us with new insights for the management and treatment of RA patients.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1436311/fullrheumatoid arthritisosteoarthritisneutrophil percentage to albumin ratioinflammationNational Health and Nutrition Examination Surveycross-sectional study |
| spellingShingle | Wenquan Ding Rui La Shenghao Wang Zhiyuan He Dinghua Jiang Zhigang Zhang Hao Ni Wu Xu Lixin Huang Qian Wu Qian Wu Associations between neutrophil percentage to albumin ratio and rheumatoid arthritis versus osteoarthritis: a comprehensive analysis utilizing the NHANES database Frontiers in Immunology rheumatoid arthritis osteoarthritis neutrophil percentage to albumin ratio inflammation National Health and Nutrition Examination Survey cross-sectional study |
| title | Associations between neutrophil percentage to albumin ratio and rheumatoid arthritis versus osteoarthritis: a comprehensive analysis utilizing the NHANES database |
| title_full | Associations between neutrophil percentage to albumin ratio and rheumatoid arthritis versus osteoarthritis: a comprehensive analysis utilizing the NHANES database |
| title_fullStr | Associations between neutrophil percentage to albumin ratio and rheumatoid arthritis versus osteoarthritis: a comprehensive analysis utilizing the NHANES database |
| title_full_unstemmed | Associations between neutrophil percentage to albumin ratio and rheumatoid arthritis versus osteoarthritis: a comprehensive analysis utilizing the NHANES database |
| title_short | Associations between neutrophil percentage to albumin ratio and rheumatoid arthritis versus osteoarthritis: a comprehensive analysis utilizing the NHANES database |
| title_sort | associations between neutrophil percentage to albumin ratio and rheumatoid arthritis versus osteoarthritis a comprehensive analysis utilizing the nhanes database |
| topic | rheumatoid arthritis osteoarthritis neutrophil percentage to albumin ratio inflammation National Health and Nutrition Examination Survey cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1436311/full |
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