Trillin inhibits MAP3K11/NF-κB/COX-2 signaling pathways through upregulation of miR-145-5p in castration-resistant prostate cancer

Trillin inhibits MAP3K11/NF-κB/COX-2 signaling pathways through upregulation of miR-145-5p in castration-resistant prostate cancer

Summary: Castration-resistant prostate cancer (CRPC) presents a significant challenge in treatment following androgen deprivation therapy. This study evaluates Trillin, a compound with antioxidant and anti-inflammatory properties, for its therapeutic potential against CRPC. Using DU145 and PC3 cell...

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Bibliographic Details
Main Authors: Yanlong Wang, Yulin Peng, Wenjun Hao, Chengjian He, Xiang Gao, Peng Liang, Haolin Zhao, Ying Wang, Liang Wang, Zhenlong Yu, Zhiyu Liu
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:iScience
Subjects:
Cancer
Cell biology
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224027329
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