Trillin inhibits MAP3K11/NF-κB/COX-2 signaling pathways through upregulation of miR-145-5p in castration-resistant prostate cancer
Summary: Castration-resistant prostate cancer (CRPC) presents a significant challenge in treatment following androgen deprivation therapy. This study evaluates Trillin, a compound with antioxidant and anti-inflammatory properties, for its therapeutic potential against CRPC. Using DU145 and PC3 cell...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224027329 |
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| author | Yanlong Wang Yulin Peng Wenjun Hao Chengjian He Xiang Gao Peng Liang Haolin Zhao Ying Wang Liang Wang Zhenlong Yu Zhiyu Liu |
| author_facet | Yanlong Wang Yulin Peng Wenjun Hao Chengjian He Xiang Gao Peng Liang Haolin Zhao Ying Wang Liang Wang Zhenlong Yu Zhiyu Liu |
| author_sort | Yanlong Wang |
| collection | DOAJ |
| description | Summary: Castration-resistant prostate cancer (CRPC) presents a significant challenge in treatment following androgen deprivation therapy. This study evaluates Trillin, a compound with antioxidant and anti-inflammatory properties, for its therapeutic potential against CRPC. Using DU145 and PC3 cell lines and a mouse xenograft model, we demonstrate that Trillin effectively inhibits CRPC cell viability, proliferation, migration, and invasion while promoting apoptosis and cell-cycle arrest. Mechanistic investigations reveal that Trillin disrupts NF-κB/COX-2 signaling by downregulating MAP3K11 and COX-2 and inhibiting the nuclear translocation of NF-κB subunits. Additionally, Trillin enhances the expression of miR-145-5p, further modulating pathways critical for CRPC progression. These findings suggest that Trillin may offer a promising alternative approach for targeting CRPC, highlighting its potential as a therapeutic agent to improve patient outcomes. |
| format | Article |
| id | doaj-art-ae018ba372d74b10862a6812cbd56abf |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-ae018ba372d74b10862a6812cbd56abf2025-01-18T05:05:03ZengElsevieriScience2589-00422025-02-01282111505Trillin inhibits MAP3K11/NF-κB/COX-2 signaling pathways through upregulation of miR-145-5p in castration-resistant prostate cancerYanlong Wang0Yulin Peng1Wenjun Hao2Chengjian He3Xiang Gao4Peng Liang5Haolin Zhao6Ying Wang7Liang Wang8Zhenlong Yu9Zhiyu Liu10Department of Urology, The Second Hospital of Dalian Medical University, Dalian 116023, ChinaCollege of Integrative Medicine, College of Pharmacy, Dalian Medical University, Dalian 116044, ChinaDepartment of Urology, The Second Hospital of Dalian Medical University, Dalian 116023, ChinaCollege of Integrative Medicine, College of Pharmacy, Dalian Medical University, Dalian 116044, ChinaDepartment of Urology, The Second Hospital of Dalian Medical University, Dalian 116023, ChinaDepartment of Urology, The Second Hospital of Dalian Medical University, Dalian 116023, ChinaDepartment of Urology, The Second Hospital of Dalian Medical University, Dalian 116023, ChinaDepartment of Urology, The Second Hospital of Dalian Medical University, Dalian 116023, ChinaDepartment of Urology, The Second Hospital of Dalian Medical University, Dalian 116023, ChinaCollege of Integrative Medicine, College of Pharmacy, Dalian Medical University, Dalian 116044, China; Corresponding authorDepartment of Urology, The Second Hospital of Dalian Medical University, Liaoning Provincial Key Laboratory of Urological Digital Precision Diagnosis and Treatment, Liaoning Engineering Research Center of Integrated Precision Diagnosis and Treatment Technology for Urological Cancer, Dalian Key Laboratory of Prostate Cancer Research, Dalian 116023, China; Corresponding authorSummary: Castration-resistant prostate cancer (CRPC) presents a significant challenge in treatment following androgen deprivation therapy. This study evaluates Trillin, a compound with antioxidant and anti-inflammatory properties, for its therapeutic potential against CRPC. Using DU145 and PC3 cell lines and a mouse xenograft model, we demonstrate that Trillin effectively inhibits CRPC cell viability, proliferation, migration, and invasion while promoting apoptosis and cell-cycle arrest. Mechanistic investigations reveal that Trillin disrupts NF-κB/COX-2 signaling by downregulating MAP3K11 and COX-2 and inhibiting the nuclear translocation of NF-κB subunits. Additionally, Trillin enhances the expression of miR-145-5p, further modulating pathways critical for CRPC progression. These findings suggest that Trillin may offer a promising alternative approach for targeting CRPC, highlighting its potential as a therapeutic agent to improve patient outcomes.http://www.sciencedirect.com/science/article/pii/S2589004224027329CancerCell biologyMolecular biology |
| spellingShingle | Yanlong Wang Yulin Peng Wenjun Hao Chengjian He Xiang Gao Peng Liang Haolin Zhao Ying Wang Liang Wang Zhenlong Yu Zhiyu Liu Trillin inhibits MAP3K11/NF-κB/COX-2 signaling pathways through upregulation of miR-145-5p in castration-resistant prostate cancer iScience Cancer Cell biology Molecular biology |
| title | Trillin inhibits MAP3K11/NF-κB/COX-2 signaling pathways through upregulation of miR-145-5p in castration-resistant prostate cancer |
| title_full | Trillin inhibits MAP3K11/NF-κB/COX-2 signaling pathways through upregulation of miR-145-5p in castration-resistant prostate cancer |
| title_fullStr | Trillin inhibits MAP3K11/NF-κB/COX-2 signaling pathways through upregulation of miR-145-5p in castration-resistant prostate cancer |
| title_full_unstemmed | Trillin inhibits MAP3K11/NF-κB/COX-2 signaling pathways through upregulation of miR-145-5p in castration-resistant prostate cancer |
| title_short | Trillin inhibits MAP3K11/NF-κB/COX-2 signaling pathways through upregulation of miR-145-5p in castration-resistant prostate cancer |
| title_sort | trillin inhibits map3k11 nf κb cox 2 signaling pathways through upregulation of mir 145 5p in castration resistant prostate cancer |
| topic | Cancer Cell biology Molecular biology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224027329 |
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