The effect of individual exercise rehabilitation program on ischemic burden and cardiac function in patients with ischemic non-obstructive coronary heart disease: a randomized parallel controlled clinical trial
BackgroundCoronary heart disease (CHD) is a pervasive chronic condition that poses a significant threat to global health and mortality worldwide. Given the severity of this disease, it is imperative to consider pivotal factors such as age, concurrent diseases, and physical frailty of patients diagno...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1421923/full |
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| author | Yuan Wen Yuanyuan Zhang Qingquan Lv Weiqun Lan Yi Shu Qiuhuan Qi Hongping Hu Othman Zakaria Saleh |
| author_facet | Yuan Wen Yuanyuan Zhang Qingquan Lv Weiqun Lan Yi Shu Qiuhuan Qi Hongping Hu Othman Zakaria Saleh |
| author_sort | Yuan Wen |
| collection | DOAJ |
| description | BackgroundCoronary heart disease (CHD) is a pervasive chronic condition that poses a significant threat to global health and mortality worldwide. Given the severity of this disease, it is imperative to consider pivotal factors such as age, concurrent diseases, and physical frailty of patients diagnosed with ischemic non-obstructive CHD prior to initiating cardiopulmonary rehabilitation. Consequently, the objective of this study is to investigate the impact of an individualized exercise rehabilitation program, on the ischemic burden in patients suffering from ischemic non-obstructive CHD.MethodsFrom February 2019 to July 2021, a cohort of one hundred patients diagnosed with ischemic non-obstructive CHD were recruited and randomly allocated into two groups. The control group underwent a standard rehabilitation program, while the intervention group participated in an individualized exercise rehabilitation program. This program was tailored to each patient, with a 50% power intensity exercise prescription derived from the results of the patient's Cardiopulmonary Exercise Testing (CPET) evaluation. The therapeutic effect, total myocardial ischemic burden (TIB), the effective rate of TIB reduction, pulmonary function indices, cardiac function, and the incidence of adverse events compared between the two groups.ResultsThe intervention group demonstrated a higher effective rate. TIB in the intervention group was significantly reduced at the 1,2, and 4-week marks post-intervention and exhibited a higher effective rate of total myocardial ischemia load reduction. Post-intervention, there were improvements in the Forced Vital Capacity (FVC), Forced Expiratory Volume in one second (FEV1), and the FEV1/FVC ratio, with the intervention group showing higher values for these parameters. Cardiac function was enhanced following the intervention, with the intervention group displaying higher Left Ventricular Ejection Fraction (LVEF) and Carbon Monoxide (CO) levels, and a lower Left Ventricular End-Diastolic Dimension (LVEDD) compared to the control group (P < 0.05).ConclusionAn individualized exercise rehabilitation regimen for patients diagnosed with ischemic non-obstructive CHD can effectively compensate for the lack of physical activity. This regimen has demonstrated its ability to enhance the clinical therapeutic effect, reduce the total load of myocardial ischemia, improve pulmonary function indices and cardiac function, and decrease the incidence of cardiovascular adverse events.
Clinical Trial Registrationidentifier (TJ-IRB20210716). |
| format | Article |
| id | doaj-art-ae004e204b574d5ca019ca87a8b7d5c6 |
| institution | DOAJ |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-ae004e204b574d5ca019ca87a8b7d5c62025-08-20T02:58:11ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-03-011210.3389/fcvm.2025.14219231421923The effect of individual exercise rehabilitation program on ischemic burden and cardiac function in patients with ischemic non-obstructive coronary heart disease: a randomized parallel controlled clinical trialYuan Wen0Yuanyuan Zhang1Qingquan Lv2Weiqun Lan3Yi Shu4Qiuhuan Qi5Hongping Hu6Othman Zakaria Saleh7Department of Cardiovascular Medicine, Wuhan Hankou Hospital, Wuhan, ChinaDepartment of Cardiovascular Medicine, Wuhan Hankou Hospital, Wuhan, ChinaDepartment of Medical Affairs, Wuhan Hankou Hospital, Wuhan, ChinaDepartment of Cardiovascular Medicine, Wuhan Hankou Hospital, Wuhan, ChinaDepartment of Cardiovascular Medicine, Wuhan Hankou Hospital, Wuhan, ChinaDepartment of Cardiovascular Medicine, Wuhan Hankou Hospital, Wuhan, ChinaDepartment of Emergency Medicine, Wuhan Hankou Hospital, Wuhan, ChinaDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, ChinaBackgroundCoronary heart disease (CHD) is a pervasive chronic condition that poses a significant threat to global health and mortality worldwide. Given the severity of this disease, it is imperative to consider pivotal factors such as age, concurrent diseases, and physical frailty of patients diagnosed with ischemic non-obstructive CHD prior to initiating cardiopulmonary rehabilitation. Consequently, the objective of this study is to investigate the impact of an individualized exercise rehabilitation program, on the ischemic burden in patients suffering from ischemic non-obstructive CHD.MethodsFrom February 2019 to July 2021, a cohort of one hundred patients diagnosed with ischemic non-obstructive CHD were recruited and randomly allocated into two groups. The control group underwent a standard rehabilitation program, while the intervention group participated in an individualized exercise rehabilitation program. This program was tailored to each patient, with a 50% power intensity exercise prescription derived from the results of the patient's Cardiopulmonary Exercise Testing (CPET) evaluation. The therapeutic effect, total myocardial ischemic burden (TIB), the effective rate of TIB reduction, pulmonary function indices, cardiac function, and the incidence of adverse events compared between the two groups.ResultsThe intervention group demonstrated a higher effective rate. TIB in the intervention group was significantly reduced at the 1,2, and 4-week marks post-intervention and exhibited a higher effective rate of total myocardial ischemia load reduction. Post-intervention, there were improvements in the Forced Vital Capacity (FVC), Forced Expiratory Volume in one second (FEV1), and the FEV1/FVC ratio, with the intervention group showing higher values for these parameters. Cardiac function was enhanced following the intervention, with the intervention group displaying higher Left Ventricular Ejection Fraction (LVEF) and Carbon Monoxide (CO) levels, and a lower Left Ventricular End-Diastolic Dimension (LVEDD) compared to the control group (P < 0.05).ConclusionAn individualized exercise rehabilitation regimen for patients diagnosed with ischemic non-obstructive CHD can effectively compensate for the lack of physical activity. This regimen has demonstrated its ability to enhance the clinical therapeutic effect, reduce the total load of myocardial ischemia, improve pulmonary function indices and cardiac function, and decrease the incidence of cardiovascular adverse events. Clinical Trial Registrationidentifier (TJ-IRB20210716).https://www.frontiersin.org/articles/10.3389/fcvm.2025.1421923/fullindividualized exercise rehabilitation programischemic non-Obstructive coronary heart diseaseischemic loadburdenheart |
| spellingShingle | Yuan Wen Yuanyuan Zhang Qingquan Lv Weiqun Lan Yi Shu Qiuhuan Qi Hongping Hu Othman Zakaria Saleh The effect of individual exercise rehabilitation program on ischemic burden and cardiac function in patients with ischemic non-obstructive coronary heart disease: a randomized parallel controlled clinical trial Frontiers in Cardiovascular Medicine individualized exercise rehabilitation program ischemic non-Obstructive coronary heart disease ischemic load burden heart |
| title | The effect of individual exercise rehabilitation program on ischemic burden and cardiac function in patients with ischemic non-obstructive coronary heart disease: a randomized parallel controlled clinical trial |
| title_full | The effect of individual exercise rehabilitation program on ischemic burden and cardiac function in patients with ischemic non-obstructive coronary heart disease: a randomized parallel controlled clinical trial |
| title_fullStr | The effect of individual exercise rehabilitation program on ischemic burden and cardiac function in patients with ischemic non-obstructive coronary heart disease: a randomized parallel controlled clinical trial |
| title_full_unstemmed | The effect of individual exercise rehabilitation program on ischemic burden and cardiac function in patients with ischemic non-obstructive coronary heart disease: a randomized parallel controlled clinical trial |
| title_short | The effect of individual exercise rehabilitation program on ischemic burden and cardiac function in patients with ischemic non-obstructive coronary heart disease: a randomized parallel controlled clinical trial |
| title_sort | effect of individual exercise rehabilitation program on ischemic burden and cardiac function in patients with ischemic non obstructive coronary heart disease a randomized parallel controlled clinical trial |
| topic | individualized exercise rehabilitation program ischemic non-Obstructive coronary heart disease ischemic load burden heart |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1421923/full |
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