High-fat diet triggers transcriptomic changes in the olfactory bulb
Metabolic imbalance contributes to cognitive impairment, anxiety, depressive behavior, and impaired olfactory perception. Recent studies have focused on olfactory dysfunction in patients with obesity and diabetes accompanied by cognitive dysfunction, considering that the synaptic signal from the olf...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025005766 |
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| author | Young-Kook Kim Danbi Jo Seoyoon Choi Juhyun Song |
| author_facet | Young-Kook Kim Danbi Jo Seoyoon Choi Juhyun Song |
| author_sort | Young-Kook Kim |
| collection | DOAJ |
| description | Metabolic imbalance contributes to cognitive impairment, anxiety, depressive behavior, and impaired olfactory perception. Recent studies have focused on olfactory dysfunction in patients with obesity and diabetes accompanied by cognitive dysfunction, considering that the synaptic signal from the olfactory bulb is directly transmitted to memory consolidation–related brain regions. This study investigated transcriptomic changes in the olfactory bulb in high-fat diet (HFD)-fed mice compared to that in normal-diet–fed mice. We sampled olfactory bulbs from HFD-fed mice, performed RNA sequencing, and measured mRNA levels in olfactory bulb tissue. Additionally, we assessed plasma cytokine levels in HFD-fed mice. We found differences in the expression of protein-coding and non-coding RNAs involved in insulin, lipid metabolism, neurogenesis, serotonin, dopamine, and gamma-aminobutyric acid–related signaling in the olfactory bulb of HFD-fed mice compared to control mice. Thus, our findings suggest potential therapeutic targets for treating olfactory dysfunction and related neural disorders in individuals with metabolic syndrome. |
| format | Article |
| id | doaj-art-adf377293aa84680831edeaad11e58d4 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-adf377293aa84680831edeaad11e58d42025-01-25T04:11:24ZengElsevierHeliyon2405-84402025-02-01113e42196High-fat diet triggers transcriptomic changes in the olfactory bulbYoung-Kook Kim0Danbi Jo1Seoyoon Choi2Juhyun Song3Biomedical Science Graduate Program (BMSGP), Chonnam National University, Hwasun, 58128, Republic of Korea; Department of Biochemistry, Chonnam National University Medical School, Hwasun, 58128, Republic of KoreaBiomedical Science Graduate Program (BMSGP), Chonnam National University, Hwasun, 58128, Republic of Korea; Department of Anatomy, Chonnam National University Medical School, Hwasun, 58128, Republic of KoreaBiomedical Science Graduate Program (BMSGP), Chonnam National University, Hwasun, 58128, Republic of Korea; Department of Anatomy, Chonnam National University Medical School, Hwasun, 58128, Republic of KoreaBiomedical Science Graduate Program (BMSGP), Chonnam National University, Hwasun, 58128, Republic of Korea; Department of Anatomy, Chonnam National University Medical School, Hwasun, 58128, Republic of Korea; Corresponding author. Department of Anatomy, Chonnam National University Medical School, Hwasun, 58128, Jeollanam-do, Republic of Korea.Metabolic imbalance contributes to cognitive impairment, anxiety, depressive behavior, and impaired olfactory perception. Recent studies have focused on olfactory dysfunction in patients with obesity and diabetes accompanied by cognitive dysfunction, considering that the synaptic signal from the olfactory bulb is directly transmitted to memory consolidation–related brain regions. This study investigated transcriptomic changes in the olfactory bulb in high-fat diet (HFD)-fed mice compared to that in normal-diet–fed mice. We sampled olfactory bulbs from HFD-fed mice, performed RNA sequencing, and measured mRNA levels in olfactory bulb tissue. Additionally, we assessed plasma cytokine levels in HFD-fed mice. We found differences in the expression of protein-coding and non-coding RNAs involved in insulin, lipid metabolism, neurogenesis, serotonin, dopamine, and gamma-aminobutyric acid–related signaling in the olfactory bulb of HFD-fed mice compared to control mice. Thus, our findings suggest potential therapeutic targets for treating olfactory dysfunction and related neural disorders in individuals with metabolic syndrome.http://www.sciencedirect.com/science/article/pii/S2405844025005766Olfactory bulbHigh-fat dietRNA sequencingLong non-coding RNACircular RNA |
| spellingShingle | Young-Kook Kim Danbi Jo Seoyoon Choi Juhyun Song High-fat diet triggers transcriptomic changes in the olfactory bulb Heliyon Olfactory bulb High-fat diet RNA sequencing Long non-coding RNA Circular RNA |
| title | High-fat diet triggers transcriptomic changes in the olfactory bulb |
| title_full | High-fat diet triggers transcriptomic changes in the olfactory bulb |
| title_fullStr | High-fat diet triggers transcriptomic changes in the olfactory bulb |
| title_full_unstemmed | High-fat diet triggers transcriptomic changes in the olfactory bulb |
| title_short | High-fat diet triggers transcriptomic changes in the olfactory bulb |
| title_sort | high fat diet triggers transcriptomic changes in the olfactory bulb |
| topic | Olfactory bulb High-fat diet RNA sequencing Long non-coding RNA Circular RNA |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025005766 |
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