The Beneficial Role of Nrf2 in the Endothelial Dysfunction of Atherosclerosis
Cardiovascular disease (CVD) is a serious public health issue in China, accounting for more than 40% of all mortality, and it is the leading cause of death worldwide. Atherosclerosis is the pathological basis for much CVD, including coronary heart disease, acute myocardial infarction, and stroke. En...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2022/4287711 |
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| _version_ | 1832565322481139712 |
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| author | Zixia Huang Mingyue Wu Lijin Zeng Deming Wang |
| author_facet | Zixia Huang Mingyue Wu Lijin Zeng Deming Wang |
| author_sort | Zixia Huang |
| collection | DOAJ |
| description | Cardiovascular disease (CVD) is a serious public health issue in China, accounting for more than 40% of all mortality, and it is the leading cause of death worldwide. Atherosclerosis is the pathological basis for much CVD, including coronary heart disease, acute myocardial infarction, and stroke. Endothelial dysfunction is an initiating and exacerbating factor in atherosclerosis. Recent research has linked oxidative stress and mitochondrial damage to endothelial dysfunction. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor with antioxidant effects that is strongly connected to several CVDs. However, the mechanism by which Nrf2 reduces CVD is unknown. Research indicates that Nrf2 improves endothelial function by resisting oxidative stress and mitochondrial damage, thereby delaying atherosclerosis. This article examines the mechanisms and potential targets of Nrf2 affecting endothelial cell function to improve atherosclerosis and to provide ideas for the development of new CVD treatments. |
| format | Article |
| id | doaj-art-addfa3c7f46d4e69a0fec638c8f83ff7 |
| institution | Kabale University |
| issn | 2090-0597 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-addfa3c7f46d4e69a0fec638c8f83ff72025-02-03T01:08:46ZengWileyCardiology Research and Practice2090-05972022-01-01202210.1155/2022/4287711The Beneficial Role of Nrf2 in the Endothelial Dysfunction of AtherosclerosisZixia Huang0Mingyue Wu1Lijin Zeng2Deming Wang3Department of AnesthesiologyDepartment of AnesthesiologyDepartment of EmergencyDepartment of AnesthesiologyCardiovascular disease (CVD) is a serious public health issue in China, accounting for more than 40% of all mortality, and it is the leading cause of death worldwide. Atherosclerosis is the pathological basis for much CVD, including coronary heart disease, acute myocardial infarction, and stroke. Endothelial dysfunction is an initiating and exacerbating factor in atherosclerosis. Recent research has linked oxidative stress and mitochondrial damage to endothelial dysfunction. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor with antioxidant effects that is strongly connected to several CVDs. However, the mechanism by which Nrf2 reduces CVD is unknown. Research indicates that Nrf2 improves endothelial function by resisting oxidative stress and mitochondrial damage, thereby delaying atherosclerosis. This article examines the mechanisms and potential targets of Nrf2 affecting endothelial cell function to improve atherosclerosis and to provide ideas for the development of new CVD treatments.http://dx.doi.org/10.1155/2022/4287711 |
| spellingShingle | Zixia Huang Mingyue Wu Lijin Zeng Deming Wang The Beneficial Role of Nrf2 in the Endothelial Dysfunction of Atherosclerosis Cardiology Research and Practice |
| title | The Beneficial Role of Nrf2 in the Endothelial Dysfunction of Atherosclerosis |
| title_full | The Beneficial Role of Nrf2 in the Endothelial Dysfunction of Atherosclerosis |
| title_fullStr | The Beneficial Role of Nrf2 in the Endothelial Dysfunction of Atherosclerosis |
| title_full_unstemmed | The Beneficial Role of Nrf2 in the Endothelial Dysfunction of Atherosclerosis |
| title_short | The Beneficial Role of Nrf2 in the Endothelial Dysfunction of Atherosclerosis |
| title_sort | beneficial role of nrf2 in the endothelial dysfunction of atherosclerosis |
| url | http://dx.doi.org/10.1155/2022/4287711 |
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