Psycho-emotional stress, folliculogenesis, and reproductive technologies: clinical and experimental data
Modern life, especially in large cities, exposes people to a high level of noise, high density of population, disrupted sleeping, large amount of excessive and controversial information as well as to other negative factors; all this may cause chronic psycho-emotional stress. The latest publications...
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| Format: | Article |
| Language: | English |
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2022-09-01
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| Series: | Вавиловский журнал генетики и селекции |
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| Online Access: | https://vavilov.elpub.ru/jour/article/view/3434 |
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| author | A. L. Levinson T. N. Igonina I. N. Rozhkova E. Yu. Brusentsev S. Ya. Amstislavsky |
| author_facet | A. L. Levinson T. N. Igonina I. N. Rozhkova E. Yu. Brusentsev S. Ya. Amstislavsky |
| author_sort | A. L. Levinson |
| collection | DOAJ |
| description | Modern life, especially in large cities, exposes people to a high level of noise, high density of population, disrupted sleeping, large amount of excessive and controversial information as well as to other negative factors; all this may cause chronic psycho-emotional stress. The latest publications often use the term “Syndrome of megalopolis”, which means disruption of sleeping, high anxiety, and altered reproductive function. Medical treatment of infertility may also be considered as a stress factor, especially when infertility lasts for years and is aggravated with emotional frustration. Long-lasting distress may worsen health in general and suppress reproductive function, in particular. The review presents the data on the effects of maternal stress on folliculogenesis, especially when assisted reproductive technologies (ARTs) are used. Clinical data are presented alongside data from laboratory animal experiments. Different maternal stress models are taken into account in respect of their inf luence on oocyte maturation and embryo development. The interfering of psycho-emotional stress and reproductive function is the focus of the review. In these situations, exogenous hormones compensate for the stress-related disruption of the hypothalamic-pituitary-gonadal axis. When ARTs are implemented, stress-induced disruption of oogenesis is realized not via a decrease in hypothalamic and pituitary hormones, but by other ways, which involve paracrine mechanisms described in this review. Based on the literature analysis, one may conclude that stress negatively affects oocyte maturation in the ovary and suppresses subsequent embryo development. The role of some ovarian paracrine factors, such as BDNF, GDF-9, HB-EGF, TNF-α, and some others has been elucidated. |
| format | Article |
| id | doaj-art-adc7c094da35467496edb5757e684c65 |
| institution | Kabale University |
| issn | 2500-3259 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj-art-adc7c094da35467496edb5757e684c652025-02-01T09:58:11ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592022-09-0126543144110.18699/VJGB-22-531277Psycho-emotional stress, folliculogenesis, and reproductive technologies: clinical and experimental dataA. L. Levinson0T. N. Igonina1I. N. Rozhkova2E. Yu. Brusentsev3S. Ya. Amstislavsky4Novosibirsk Center of Reproductive Medicine; Novosibirsk State UniversityInstitute of Cytology and Genetics of the Siberian Branch of the Russian Academy of SciencesInstitute of Cytology and Genetics of the Siberian Branch of the Russian Academy of SciencesInstitute of Cytology and Genetics of the Siberian Branch of the Russian Academy of SciencesInstitute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences; Novosibirsk State UniversityModern life, especially in large cities, exposes people to a high level of noise, high density of population, disrupted sleeping, large amount of excessive and controversial information as well as to other negative factors; all this may cause chronic psycho-emotional stress. The latest publications often use the term “Syndrome of megalopolis”, which means disruption of sleeping, high anxiety, and altered reproductive function. Medical treatment of infertility may also be considered as a stress factor, especially when infertility lasts for years and is aggravated with emotional frustration. Long-lasting distress may worsen health in general and suppress reproductive function, in particular. The review presents the data on the effects of maternal stress on folliculogenesis, especially when assisted reproductive technologies (ARTs) are used. Clinical data are presented alongside data from laboratory animal experiments. Different maternal stress models are taken into account in respect of their inf luence on oocyte maturation and embryo development. The interfering of psycho-emotional stress and reproductive function is the focus of the review. In these situations, exogenous hormones compensate for the stress-related disruption of the hypothalamic-pituitary-gonadal axis. When ARTs are implemented, stress-induced disruption of oogenesis is realized not via a decrease in hypothalamic and pituitary hormones, but by other ways, which involve paracrine mechanisms described in this review. Based on the literature analysis, one may conclude that stress negatively affects oocyte maturation in the ovary and suppresses subsequent embryo development. The role of some ovarian paracrine factors, such as BDNF, GDF-9, HB-EGF, TNF-α, and some others has been elucidated.https://vavilov.elpub.ru/jour/article/view/3434stresslong-term effectsfolliculogenesisassisted reproductive technologiespreimplantation embryo |
| spellingShingle | A. L. Levinson T. N. Igonina I. N. Rozhkova E. Yu. Brusentsev S. Ya. Amstislavsky Psycho-emotional stress, folliculogenesis, and reproductive technologies: clinical and experimental data Вавиловский журнал генетики и селекции stress long-term effects folliculogenesis assisted reproductive technologies preimplantation embryo |
| title | Psycho-emotional stress, folliculogenesis, and reproductive technologies: clinical and experimental data |
| title_full | Psycho-emotional stress, folliculogenesis, and reproductive technologies: clinical and experimental data |
| title_fullStr | Psycho-emotional stress, folliculogenesis, and reproductive technologies: clinical and experimental data |
| title_full_unstemmed | Psycho-emotional stress, folliculogenesis, and reproductive technologies: clinical and experimental data |
| title_short | Psycho-emotional stress, folliculogenesis, and reproductive technologies: clinical and experimental data |
| title_sort | psycho emotional stress folliculogenesis and reproductive technologies clinical and experimental data |
| topic | stress long-term effects folliculogenesis assisted reproductive technologies preimplantation embryo |
| url | https://vavilov.elpub.ru/jour/article/view/3434 |
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