Nuclear DNA Content of Fine Needle Aspirates of Invasive Ductal Carcinomas of the Breast
Patients with aggressive breast cancers benefit from chemotherapy prior to surgery. If the biology of the breast cancers were better characterised pre‐operatively, more patients at risk could be offered chemotherapy. We have assessed nuclear DNA content of fine needle aspirates (FNA) of 103 invasive...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1997-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/1997/461402 |
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| _version_ | 1832545664120127488 |
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| author | Sudip Sarker Allan Spigelman Marjorie Walker Dulcie Coleman |
| author_facet | Sudip Sarker Allan Spigelman Marjorie Walker Dulcie Coleman |
| author_sort | Sudip Sarker |
| collection | DOAJ |
| description | Patients with aggressive breast cancers benefit from chemotherapy prior to surgery. If the biology of the breast cancers were better characterised pre‐operatively, more patients at risk could be offered chemotherapy. We have assessed nuclear DNA content of fine needle aspirates (FNA) of 103 invasive ductal breast cancers and compared this to tumour size, node status and histological grade. Median follow‐up was 18 months so no prognostic studies were made. Diploid and non‐diploid tumours were distributed equally in node negative and positive patients. However non‐diploidy status increased in line with known prognostic markers of tumour size and histological grade. This suggests that ploidy might contribute to the pre‐operative assessment of prognosis. We conclude that nuclear DNA of breast cancer FNAs may be of value in the pre‐operative biological assessment of breast cancer patients. |
| format | Article |
| id | doaj-art-ada7e3c64f2045f88ac03d745f266c47 |
| institution | Kabale University |
| issn | 0921-8912 1878-3651 |
| language | English |
| publishDate | 1997-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-ada7e3c64f2045f88ac03d745f266c472025-02-03T07:25:11ZengWileyAnalytical Cellular Pathology0921-89121878-36511997-01-011311810.1155/1997/461402Nuclear DNA Content of Fine Needle Aspirates of Invasive Ductal Carcinomas of the BreastSudip Sarker0Allan Spigelman1Marjorie Walker2Dulcie Coleman3Cytopathology, Cytogenetics, St Mary’s Hospital Medical School, Imperial College of Science, Technology and Medicine, University of London, London W2 1NY, UKAcademic Surgical, St Mary’s Hospital Medical School, Imperial College of Science, Technology and Medicine, University of London, London W2 1NY, UKHistopathology Units, St Mary’s Hospital Medical School, Imperial College of Science, Technology and Medicine, University of London, London W2 1NY, UKCytopathology, Cytogenetics, St Mary’s Hospital Medical School, Imperial College of Science, Technology and Medicine, University of London, London W2 1NY, UKPatients with aggressive breast cancers benefit from chemotherapy prior to surgery. If the biology of the breast cancers were better characterised pre‐operatively, more patients at risk could be offered chemotherapy. We have assessed nuclear DNA content of fine needle aspirates (FNA) of 103 invasive ductal breast cancers and compared this to tumour size, node status and histological grade. Median follow‐up was 18 months so no prognostic studies were made. Diploid and non‐diploid tumours were distributed equally in node negative and positive patients. However non‐diploidy status increased in line with known prognostic markers of tumour size and histological grade. This suggests that ploidy might contribute to the pre‐operative assessment of prognosis. We conclude that nuclear DNA of breast cancer FNAs may be of value in the pre‐operative biological assessment of breast cancer patients.http://dx.doi.org/10.1155/1997/461402 |
| spellingShingle | Sudip Sarker Allan Spigelman Marjorie Walker Dulcie Coleman Nuclear DNA Content of Fine Needle Aspirates of Invasive Ductal Carcinomas of the Breast Analytical Cellular Pathology |
| title | Nuclear DNA Content of Fine Needle Aspirates of Invasive Ductal Carcinomas of the Breast |
| title_full | Nuclear DNA Content of Fine Needle Aspirates of Invasive Ductal Carcinomas of the Breast |
| title_fullStr | Nuclear DNA Content of Fine Needle Aspirates of Invasive Ductal Carcinomas of the Breast |
| title_full_unstemmed | Nuclear DNA Content of Fine Needle Aspirates of Invasive Ductal Carcinomas of the Breast |
| title_short | Nuclear DNA Content of Fine Needle Aspirates of Invasive Ductal Carcinomas of the Breast |
| title_sort | nuclear dna content of fine needle aspirates of invasive ductal carcinomas of the breast |
| url | http://dx.doi.org/10.1155/1997/461402 |
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