The Role of PCR in Diagnosis of a Rare Appendicular Tuberculosis and Mini Literature Review
Tuberculosis is a prevalent public health problem especially in the poor developing countries and results in significant mortality. Albeit tuberculosis almost always affects any organ or system of the body, abdominal tuberculosis is less frequent; moreover, tuberculous appendicitis is very rare with...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Case Reports in Gastrointestinal Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/8356708 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548211021053952 |
|---|---|
| author | Asmerom Tesfamariam Sengal Ahmed Abdalla Mohamedani Hanan Hasaan Hussein Alaa Kamal |
| author_facet | Asmerom Tesfamariam Sengal Ahmed Abdalla Mohamedani Hanan Hasaan Hussein Alaa Kamal |
| author_sort | Asmerom Tesfamariam Sengal |
| collection | DOAJ |
| description | Tuberculosis is a prevalent public health problem especially in the poor developing countries and results in significant mortality. Albeit tuberculosis almost always affects any organ or system of the body, abdominal tuberculosis is less frequent; moreover, tuberculous appendicitis is very rare with an incidence estimated at about 0.1–0.6% of all gastrointestinal tuberculosis. The purpose of this report was to present an unusual case of primary tuberculous appendicitis and the approach used for accurate diagnosis as well as a current update on the disease. We are reporting a 30-year-old male who presented with acute abdominal pain, fever, and vomiting and was admitted with the clinical diagnosis of acute appendicitis. Patient was investigated thoroughly and histopathologic examination was strongly suggestive of tuberculous appendicitis; however, Ziehl-Neelsen (ZN) was negative in tissue section. To confirm the diagnosis, molecular biology [polymerase chain reaction (PCR)] study was performed from the formalin fixed paraffin embedded (FFPE) appendicular tissue and revealed presence of Mycobacterium tuberculosis. As there are numerous differential diagnoses in granulomatous lesions of appendix and due to the fact that appendicular tuberculosis is a rare phenomenon; verification etiologic agent is crucial for appropriate management of the disease. |
| format | Article |
| id | doaj-art-ada215b2e57d46698c1a0c79fa47d057 |
| institution | Kabale University |
| issn | 2090-6528 2090-6536 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Gastrointestinal Medicine |
| spelling | doaj-art-ada215b2e57d46698c1a0c79fa47d0572025-02-03T06:41:57ZengWileyCase Reports in Gastrointestinal Medicine2090-65282090-65362016-01-01201610.1155/2016/83567088356708The Role of PCR in Diagnosis of a Rare Appendicular Tuberculosis and Mini Literature ReviewAsmerom Tesfamariam Sengal0Ahmed Abdalla Mohamedani1Hanan Hasaan Hussein2Alaa Kamal3Pathology Department, Faculty of Medicine, University of Gezira, P.O. Box 20, Wad Madani, Al Gezira, SudanPathology Department, Faculty of Medicine, University of Gezira, P.O. Box 20, Wad Madani, Al Gezira, SudanPathology Department, Gezira Medical Laboratory, Wad Madani, Al Gezira, SudanPathology Department, Faculty of Medicine, University of Gezira, P.O. Box 20, Wad Madani, Al Gezira, SudanTuberculosis is a prevalent public health problem especially in the poor developing countries and results in significant mortality. Albeit tuberculosis almost always affects any organ or system of the body, abdominal tuberculosis is less frequent; moreover, tuberculous appendicitis is very rare with an incidence estimated at about 0.1–0.6% of all gastrointestinal tuberculosis. The purpose of this report was to present an unusual case of primary tuberculous appendicitis and the approach used for accurate diagnosis as well as a current update on the disease. We are reporting a 30-year-old male who presented with acute abdominal pain, fever, and vomiting and was admitted with the clinical diagnosis of acute appendicitis. Patient was investigated thoroughly and histopathologic examination was strongly suggestive of tuberculous appendicitis; however, Ziehl-Neelsen (ZN) was negative in tissue section. To confirm the diagnosis, molecular biology [polymerase chain reaction (PCR)] study was performed from the formalin fixed paraffin embedded (FFPE) appendicular tissue and revealed presence of Mycobacterium tuberculosis. As there are numerous differential diagnoses in granulomatous lesions of appendix and due to the fact that appendicular tuberculosis is a rare phenomenon; verification etiologic agent is crucial for appropriate management of the disease.http://dx.doi.org/10.1155/2016/8356708 |
| spellingShingle | Asmerom Tesfamariam Sengal Ahmed Abdalla Mohamedani Hanan Hasaan Hussein Alaa Kamal The Role of PCR in Diagnosis of a Rare Appendicular Tuberculosis and Mini Literature Review Case Reports in Gastrointestinal Medicine |
| title | The Role of PCR in Diagnosis of a Rare Appendicular Tuberculosis and Mini Literature Review |
| title_full | The Role of PCR in Diagnosis of a Rare Appendicular Tuberculosis and Mini Literature Review |
| title_fullStr | The Role of PCR in Diagnosis of a Rare Appendicular Tuberculosis and Mini Literature Review |
| title_full_unstemmed | The Role of PCR in Diagnosis of a Rare Appendicular Tuberculosis and Mini Literature Review |
| title_short | The Role of PCR in Diagnosis of a Rare Appendicular Tuberculosis and Mini Literature Review |
| title_sort | role of pcr in diagnosis of a rare appendicular tuberculosis and mini literature review |
| url | http://dx.doi.org/10.1155/2016/8356708 |
| work_keys_str_mv | AT asmeromtesfamariamsengal theroleofpcrindiagnosisofarareappendiculartuberculosisandminiliteraturereview AT ahmedabdallamohamedani theroleofpcrindiagnosisofarareappendiculartuberculosisandminiliteraturereview AT hananhasaanhussein theroleofpcrindiagnosisofarareappendiculartuberculosisandminiliteraturereview AT alaakamal theroleofpcrindiagnosisofarareappendiculartuberculosisandminiliteraturereview AT asmeromtesfamariamsengal roleofpcrindiagnosisofarareappendiculartuberculosisandminiliteraturereview AT ahmedabdallamohamedani roleofpcrindiagnosisofarareappendiculartuberculosisandminiliteraturereview AT hananhasaanhussein roleofpcrindiagnosisofarareappendiculartuberculosisandminiliteraturereview AT alaakamal roleofpcrindiagnosisofarareappendiculartuberculosisandminiliteraturereview |