The inheritance of resistance alleles in multiple sclerosis.

The inheritance of resistance alleles in multiple sclerosis.

Multiple sclerosis (MS) is a complex trait in which alleles at or near the class II loci HLA-DRB1 and HLA-DQB1 contribute significantly to genetic risk. HLA-DRB1*15 and HLA-DRB1*17-bearing haplotypes and interactions at the HLA-DRB1 locus increase risk of MS but it has taken large samples to identif...

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Bibliographic Details
Main Authors: Sreeram V Ramagopalan, Andrew P Morris, David A Dyment, Blanca M Herrera, Gabriele C DeLuca, Matthew R Lincoln, Sarah M Orton, Michael J Chao, A Dessa Sadovnick, George C Ebers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-09-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0030150&type=printable
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