MELK prevents radiofrequency ablation-induced immunogenic cell death and antitumor immune response by stabilizing FABP5 in hepatocellular malignancies

MELK prevents radiofrequency ablation-induced immunogenic cell death and antitumor immune response by stabilizing FABP5 in hepatocellular malignancies

Abstract Background Radiofrequency ablation (RFA) is an efficient treatment with unlimited potential for liver cancer that can effectively reduce patient mortality. Understanding the biological process related with RFA treatment is important for improving treatment strategy. This study aimed to iden...

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Bibliographic Details
Main Authors: Bu-Fu Tang, Wang-Ting Xu, Shi-Ji Fang, Jin-Yu Zhu, Rong-Fang Qiu, Lin Shen, Yang Yang, Qiao-You Weng, Ya-Jie Wang, Jia-Yi Ding, Xiao-Jie Zhang, Wei-Qian Chen, Li-Yun Zheng, Jing-Jing Song, Biao Chen, Zhong-Wei Zhao, Min-Jiang Chen, Jian-Song Ji
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Military Medical Research
Subjects:
Radiofrequency ablation
Liver cancer
Maternal embryonic leucine zipper kinase (MELK)
Fatty acid-binding protein 5 (FABP5)
Immune microenvironment
Nanoparticles
Online Access:https://doi.org/10.1186/s40779-024-00588-7
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