Refractory Acute Interstitial Nephritis in the Setting of Nivolumab Therapy
A 65-year-old male patient with metastatic CCRCC developed steroid-dependent, grade 3 AIN secondary to nivolumab weeks after its initiation that resulted in 3 hospitalizations with acute renal failure. The patient was started on MM and his AIN was successfully controlled after a 2-year period of fol...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2021/6640154 |
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| _version_ | 1832556909820903424 |
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| author | Antonio Faieta Tavis Dancik |
| author_facet | Antonio Faieta Tavis Dancik |
| author_sort | Antonio Faieta |
| collection | DOAJ |
| description | A 65-year-old male patient with metastatic CCRCC developed steroid-dependent, grade 3 AIN secondary to nivolumab weeks after its initiation that resulted in 3 hospitalizations with acute renal failure. The patient was started on MM and his AIN was successfully controlled after a 2-year period of follow-up. Refractory renal AIN resulting from PD-1 inhibitor use is rare, and its successful treatment with mofetil mycophenolate with a 2-year follow-up in a patient with metastatic CCRCC has not been reported. This case is important because not only was his renal irAEs controlled but also long-term treatment with MM did not result in progression of metastatic disease. |
| format | Article |
| id | doaj-art-ad829acd377345c2bd3a262de6dbaf83 |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-ad829acd377345c2bd3a262de6dbaf832025-02-03T05:44:12ZengWileyCase Reports in Nephrology2090-66412090-665X2021-01-01202110.1155/2021/66401546640154Refractory Acute Interstitial Nephritis in the Setting of Nivolumab TherapyAntonio Faieta0Tavis Dancik1Department of Internal Medicine, Beaumont Health System, Royal Oak, MI, USADepartment of Nephrology, Beaumont Health System, Royal Oak, MI, USAA 65-year-old male patient with metastatic CCRCC developed steroid-dependent, grade 3 AIN secondary to nivolumab weeks after its initiation that resulted in 3 hospitalizations with acute renal failure. The patient was started on MM and his AIN was successfully controlled after a 2-year period of follow-up. Refractory renal AIN resulting from PD-1 inhibitor use is rare, and its successful treatment with mofetil mycophenolate with a 2-year follow-up in a patient with metastatic CCRCC has not been reported. This case is important because not only was his renal irAEs controlled but also long-term treatment with MM did not result in progression of metastatic disease.http://dx.doi.org/10.1155/2021/6640154 |
| spellingShingle | Antonio Faieta Tavis Dancik Refractory Acute Interstitial Nephritis in the Setting of Nivolumab Therapy Case Reports in Nephrology |
| title | Refractory Acute Interstitial Nephritis in the Setting of Nivolumab Therapy |
| title_full | Refractory Acute Interstitial Nephritis in the Setting of Nivolumab Therapy |
| title_fullStr | Refractory Acute Interstitial Nephritis in the Setting of Nivolumab Therapy |
| title_full_unstemmed | Refractory Acute Interstitial Nephritis in the Setting of Nivolumab Therapy |
| title_short | Refractory Acute Interstitial Nephritis in the Setting of Nivolumab Therapy |
| title_sort | refractory acute interstitial nephritis in the setting of nivolumab therapy |
| url | http://dx.doi.org/10.1155/2021/6640154 |
| work_keys_str_mv | AT antoniofaieta refractoryacuteinterstitialnephritisinthesettingofnivolumabtherapy AT tavisdancik refractoryacuteinterstitialnephritisinthesettingofnivolumabtherapy |