Polysialic acid is upregulated on activated immune cells and negatively regulates anticancer immune activity

Suppression of anticancer immune function is a key driver of tumorigenesis. Identifying molecular pathways that inhibit anticancer immunity is critical for developing novel immunotherapeutics. One such molecule that has recently been identified is the carbohydrate polysialic acid (polySia), whose ex...

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Bibliographic Details
Main Authors: Olivia Drummond-Guy, John Daly, Angeline Wu, Natalie Stewart, Katy Milne, Chloe Duff, Brad H. Nelson, Karla C. Williams, Simon Wisnovsky
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Oncology
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Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1520948/full
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