Current Trends on Solid Dispersions: Past, Present, and Future
Solid dispersions have achieved significant interest as an effective means of enhancing the dissolution rate and thus the bioavailability of a range of weakly water-soluble drugs. Solid dispersions of weakly water-soluble drugs with water-soluble carriers have lowered the frequency of these problems...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Advances in Pharmacological and Pharmaceutical Sciences |
| Online Access: | http://dx.doi.org/10.1155/2022/5916013 |
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| author | Ruba Malkawi Walla I. Malkawi Yahia Al-Mahmoud Jawad Tawalbeh |
| author_facet | Ruba Malkawi Walla I. Malkawi Yahia Al-Mahmoud Jawad Tawalbeh |
| author_sort | Ruba Malkawi |
| collection | DOAJ |
| description | Solid dispersions have achieved significant interest as an effective means of enhancing the dissolution rate and thus the bioavailability of a range of weakly water-soluble drugs. Solid dispersions of weakly water-soluble drugs with water-soluble carriers have lowered the frequency of these problems and improved dissolution. Solid dispersion is a solubilization technology emphasizing mainly on, drug-polymer two-component systems in which drug dispersion and its stabilization is the key to formulation development. Therefore, this technology is recognized as an exceptionally useful means of improving the dissolution properties of poorly water-soluble drugs and in the latest years, a big deal of understanding has been accumulated about solid dispersion, however, their commercial application is limited. In this review article, emphasis is placed on solubility, BCS classification, and carriers. Moreover, this article presents the diverse preparation techniques for solid dispersion and gathers some of the recent technological transfers. The different types of solid dispersions based on the carrier used and molecular arrangement were underlined. Additionally, it summarizes the mechanisms, the methods of preparing solid dispersions, and the marketed drugs that are available using solid dispersion approaches. |
| format | Article |
| id | doaj-art-ad7b5457e80c4ba4adaf0a45a7f5726a |
| institution | Kabale University |
| issn | 2633-4690 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological and Pharmaceutical Sciences |
| spelling | doaj-art-ad7b5457e80c4ba4adaf0a45a7f5726a2025-02-03T06:13:02ZengWileyAdvances in Pharmacological and Pharmaceutical Sciences2633-46902022-01-01202210.1155/2022/5916013Current Trends on Solid Dispersions: Past, Present, and FutureRuba Malkawi0Walla I. Malkawi1Yahia Al-Mahmoud2Jawad Tawalbeh3School of PharmacySchool of PharmacySchool of PharmacySchool of BusinessSolid dispersions have achieved significant interest as an effective means of enhancing the dissolution rate and thus the bioavailability of a range of weakly water-soluble drugs. Solid dispersions of weakly water-soluble drugs with water-soluble carriers have lowered the frequency of these problems and improved dissolution. Solid dispersion is a solubilization technology emphasizing mainly on, drug-polymer two-component systems in which drug dispersion and its stabilization is the key to formulation development. Therefore, this technology is recognized as an exceptionally useful means of improving the dissolution properties of poorly water-soluble drugs and in the latest years, a big deal of understanding has been accumulated about solid dispersion, however, their commercial application is limited. In this review article, emphasis is placed on solubility, BCS classification, and carriers. Moreover, this article presents the diverse preparation techniques for solid dispersion and gathers some of the recent technological transfers. The different types of solid dispersions based on the carrier used and molecular arrangement were underlined. Additionally, it summarizes the mechanisms, the methods of preparing solid dispersions, and the marketed drugs that are available using solid dispersion approaches.http://dx.doi.org/10.1155/2022/5916013 |
| spellingShingle | Ruba Malkawi Walla I. Malkawi Yahia Al-Mahmoud Jawad Tawalbeh Current Trends on Solid Dispersions: Past, Present, and Future Advances in Pharmacological and Pharmaceutical Sciences |
| title | Current Trends on Solid Dispersions: Past, Present, and Future |
| title_full | Current Trends on Solid Dispersions: Past, Present, and Future |
| title_fullStr | Current Trends on Solid Dispersions: Past, Present, and Future |
| title_full_unstemmed | Current Trends on Solid Dispersions: Past, Present, and Future |
| title_short | Current Trends on Solid Dispersions: Past, Present, and Future |
| title_sort | current trends on solid dispersions past present and future |
| url | http://dx.doi.org/10.1155/2022/5916013 |
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