Research progress in unilateral moyamoya disease
Unilateral moyamoya disease (U-MMD) is a chronic vascular disease characterized by progressive stenosis and occlusion of the terminal end of the internal carotid artery and its main branches, resulting in the appearance of moyamoya-like blood vessels at the base of the brain. The etiology of U-MMD i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2025.1503639/full |
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| author | Xiaokuan Hao Cunxin Tan Ziqi Liu Yang Tie Yanru Wang Shihao He Ran Duan Rong Wang Rong Wang |
| author_facet | Xiaokuan Hao Cunxin Tan Ziqi Liu Yang Tie Yanru Wang Shihao He Ran Duan Rong Wang Rong Wang |
| author_sort | Xiaokuan Hao |
| collection | DOAJ |
| description | Unilateral moyamoya disease (U-MMD) is a chronic vascular disease characterized by progressive stenosis and occlusion of the terminal end of the internal carotid artery and its main branches, resulting in the appearance of moyamoya-like blood vessels at the base of the brain. The etiology of U-MMD is unknown, it accounts for 9.7–17.8% of all moyamoya disease, and the family incidence is 5.5–13.3%. The clinical characteristics are similar to those of typical moyamoya disease, but there are some differences. U-MMD can progress to bilateral moyamoya disease with a median probability of 29.01% (ranging from 6.3 to 58.8%), and there are many risk factors that promote its development. Surgical treatment can effectively reduce the incidence of ischemic stroke and improve prognosis. However, the timing and indications for surgery require further investigation. This article reviews the latest research progress on the etiology, epidemiology, clinical and radiological characteristics, progression, treatment, and prognosis of U-MMD. |
| format | Article |
| id | doaj-art-ad70680a924d43d385e5cd0186fd263a |
| institution | Kabale University |
| issn | 1662-5161 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj-art-ad70680a924d43d385e5cd0186fd263a2025-01-27T06:40:20ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612025-01-011910.3389/fnhum.2025.15036391503639Research progress in unilateral moyamoya diseaseXiaokuan Hao0Cunxin Tan1Ziqi Liu2Yang Tie3Yanru Wang4Shihao He5Ran Duan6Rong Wang7Rong Wang8Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Peking University International Hospital, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Neurosurgery, Peking University International Hospital, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaUnilateral moyamoya disease (U-MMD) is a chronic vascular disease characterized by progressive stenosis and occlusion of the terminal end of the internal carotid artery and its main branches, resulting in the appearance of moyamoya-like blood vessels at the base of the brain. The etiology of U-MMD is unknown, it accounts for 9.7–17.8% of all moyamoya disease, and the family incidence is 5.5–13.3%. The clinical characteristics are similar to those of typical moyamoya disease, but there are some differences. U-MMD can progress to bilateral moyamoya disease with a median probability of 29.01% (ranging from 6.3 to 58.8%), and there are many risk factors that promote its development. Surgical treatment can effectively reduce the incidence of ischemic stroke and improve prognosis. However, the timing and indications for surgery require further investigation. This article reviews the latest research progress on the etiology, epidemiology, clinical and radiological characteristics, progression, treatment, and prognosis of U-MMD.https://www.frontiersin.org/articles/10.3389/fnhum.2025.1503639/fullunilateral moyamoya diseaseetiologyepidemiologyclinical courseprogressionsurgery |
| spellingShingle | Xiaokuan Hao Cunxin Tan Ziqi Liu Yang Tie Yanru Wang Shihao He Ran Duan Rong Wang Rong Wang Research progress in unilateral moyamoya disease Frontiers in Human Neuroscience unilateral moyamoya disease etiology epidemiology clinical course progression surgery |
| title | Research progress in unilateral moyamoya disease |
| title_full | Research progress in unilateral moyamoya disease |
| title_fullStr | Research progress in unilateral moyamoya disease |
| title_full_unstemmed | Research progress in unilateral moyamoya disease |
| title_short | Research progress in unilateral moyamoya disease |
| title_sort | research progress in unilateral moyamoya disease |
| topic | unilateral moyamoya disease etiology epidemiology clinical course progression surgery |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2025.1503639/full |
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