Static Magnetic Field Accelerates Diabetic Wound Healing by Facilitating Resolution of Inflammation
Impaired wound healing is commonly encountered in patients with diabetes mellitus, which may lead to severe outcomes such as amputation, if untreated timely. Macrophage plays a critical role in the healing process including the resolution phase. Although magnetic therapy is known to improve microcir...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2019/5641271 |
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| author | Wenlong Shang Guilin Chen Yinxiu Li Yujuan Zhuo Yuhong Wang Zhicai Fang Ying Yu Huiwen Ren |
| author_facet | Wenlong Shang Guilin Chen Yinxiu Li Yujuan Zhuo Yuhong Wang Zhicai Fang Ying Yu Huiwen Ren |
| author_sort | Wenlong Shang |
| collection | DOAJ |
| description | Impaired wound healing is commonly encountered in patients with diabetes mellitus, which may lead to severe outcomes such as amputation, if untreated timely. Macrophage plays a critical role in the healing process including the resolution phase. Although magnetic therapy is known to improve microcirculation, its effect on wound healing remains uncertain. In the present study, we found that 0.6 T static magnetic field (SMF) significantly accelerated wound closure and elevated reepithelialization and revascularization in diabetic mice. Notably, SMF promoted the wound healing by skewing the macrophage polarization towards M2 phenotype, thus facilitating the resolution of inflammation. In addition, SMF upregulated anti-inflammatory gene expression via activating STAT6 and suppressing STAT1 in macrophage. Taken together, our results indicate that SMF may be a promising adjuvant therapeutic tool for treating diabetic wounds. |
| format | Article |
| id | doaj-art-ad6f5db9794c47eb896f6f92ca7de667 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-ad6f5db9794c47eb896f6f92ca7de6672025-02-03T06:01:26ZengWileyJournal of Diabetes Research2314-67452314-67532019-01-01201910.1155/2019/56412715641271Static Magnetic Field Accelerates Diabetic Wound Healing by Facilitating Resolution of InflammationWenlong Shang0Guilin Chen1Yinxiu Li2Yujuan Zhuo3Yuhong Wang4Zhicai Fang5Ying Yu6Huiwen Ren7Department of Pharmacology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin, ChinaDepartment of Pharmacology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin, ChinaDepartment of Pharmacology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin, ChinaDepartment of Pharmacology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin, ChinaDepartment of Pharmacology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin, ChinaHeye Health Industrial Research Institute of Zhejiang Heye Health Technology, Anji, Zhejiang 313300, ChinaDepartment of Pharmacology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin, ChinaDepartment of Pharmacology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin, ChinaImpaired wound healing is commonly encountered in patients with diabetes mellitus, which may lead to severe outcomes such as amputation, if untreated timely. Macrophage plays a critical role in the healing process including the resolution phase. Although magnetic therapy is known to improve microcirculation, its effect on wound healing remains uncertain. In the present study, we found that 0.6 T static magnetic field (SMF) significantly accelerated wound closure and elevated reepithelialization and revascularization in diabetic mice. Notably, SMF promoted the wound healing by skewing the macrophage polarization towards M2 phenotype, thus facilitating the resolution of inflammation. In addition, SMF upregulated anti-inflammatory gene expression via activating STAT6 and suppressing STAT1 in macrophage. Taken together, our results indicate that SMF may be a promising adjuvant therapeutic tool for treating diabetic wounds.http://dx.doi.org/10.1155/2019/5641271 |
| spellingShingle | Wenlong Shang Guilin Chen Yinxiu Li Yujuan Zhuo Yuhong Wang Zhicai Fang Ying Yu Huiwen Ren Static Magnetic Field Accelerates Diabetic Wound Healing by Facilitating Resolution of Inflammation Journal of Diabetes Research |
| title | Static Magnetic Field Accelerates Diabetic Wound Healing by Facilitating Resolution of Inflammation |
| title_full | Static Magnetic Field Accelerates Diabetic Wound Healing by Facilitating Resolution of Inflammation |
| title_fullStr | Static Magnetic Field Accelerates Diabetic Wound Healing by Facilitating Resolution of Inflammation |
| title_full_unstemmed | Static Magnetic Field Accelerates Diabetic Wound Healing by Facilitating Resolution of Inflammation |
| title_short | Static Magnetic Field Accelerates Diabetic Wound Healing by Facilitating Resolution of Inflammation |
| title_sort | static magnetic field accelerates diabetic wound healing by facilitating resolution of inflammation |
| url | http://dx.doi.org/10.1155/2019/5641271 |
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