The Role of Atrial Fibrillation and Oral Anticoagulation Status in Health‐Related Quality of Life 12 Months After Ischemic Stroke or TIA
ABSTRACT Aims Atrial fibrillation (AF) accounts for about 20% of all ischemic strokes worldwide. It is known that AF impairs health‐related quality of life (HRQOL) in the general population, but data on HRQOL in stroke patients with newly diagnosed AF are sparse. Methods Post hoc analysis of the pro...
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2025-01-01
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| Online Access: | https://doi.org/10.1002/brb3.70248 |
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| author | Manuel C. Olma Lena Steindorf‐Sabath Serdar Tütüncü Claudia Kunze Cornelia Fiessler Paulus Kirchhof Joanna Dietzel Johannes Schurig Patrick Oschmann Ludwig Niehaus Christian Urbanek Götz Thomalla Darius G. Nabavi Joachim Röther Ulrich Laufs Roland Veltkamp Peter U. Heuschmann Karl Georg Haeusler Matthias Endres for the MonDAFIS Investigators |
| author_facet | Manuel C. Olma Lena Steindorf‐Sabath Serdar Tütüncü Claudia Kunze Cornelia Fiessler Paulus Kirchhof Joanna Dietzel Johannes Schurig Patrick Oschmann Ludwig Niehaus Christian Urbanek Götz Thomalla Darius G. Nabavi Joachim Röther Ulrich Laufs Roland Veltkamp Peter U. Heuschmann Karl Georg Haeusler Matthias Endres for the MonDAFIS Investigators |
| author_sort | Manuel C. Olma |
| collection | DOAJ |
| description | ABSTRACT Aims Atrial fibrillation (AF) accounts for about 20% of all ischemic strokes worldwide. It is known that AF impairs health‐related quality of life (HRQOL) in the general population, but data on HRQOL in stroke patients with newly diagnosed AF are sparse. Methods Post hoc analysis of the prospective, investigator‐initiated, multicenter MonDAFIS study (NCT02204267) to analyze whether AF‐related oral anticoagulation (OAC), and/or AF‐symptom severity are associated with HRQOL after ischemic stroke or transient ischemic attack (TIA). HRQOL was measured using the EQ‐5D‐3L‐questionnaire (including EQ‐index/EQ‐VAS) at baseline and after 12 months using multivariable linear mixed models. AF symptom severity was assessed using the European Heart Rhythm Association classification and symptom severity score (EHRA score) categorizing patients with no/mild/severe/disabling AF‐related symptoms. Results A first episode of AF was detected in 261/2927 (8.9%) patients within 12 months after the index stroke and 227/2920 (7.8%) patients had AF and were anticoagulated at 12 months. HRQOL (measured by EQ‐index, n = 2495 patients) was higher in AF patients on OAC compared to AF patients without OAC at 12 months after stroke (mean difference: MD: –16.8, 95% CI: 5.6 to 28.0), and similar in AF patients under OAC compared with patients without AF (MD: 2.0, 95% CI: –2.2 to 6.3). AF‐related symptoms were negatively associated with HRQOL (measured by EQ‐index) indicating that stroke patients with AF‐related symptoms had a lower HRQOL compared to asymptomatic AF patients (mild vs. asymptomatic: MD: –9.0, 95% CI: –17.7 to –0.3; severe/disabling vs. asymptomatic: MD: –19.1, 95% CI: –34.7 to –3.4). Discussion Stroke patients with newly diagnosed AF are at risk of lower quality of life at 12 months, depending on OAC status and AF symptom severity. |
| format | Article |
| id | doaj-art-ad6e2d01d82c471cbedcc0027a399480 |
| institution | Kabale University |
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| spelling | doaj-art-ad6e2d01d82c471cbedcc0027a3994802025-01-29T13:36:39ZengWileyBrain and Behavior2162-32792025-01-01151n/an/a10.1002/brb3.70248The Role of Atrial Fibrillation and Oral Anticoagulation Status in Health‐Related Quality of Life 12 Months After Ischemic Stroke or TIAManuel C. Olma0Lena Steindorf‐Sabath1Serdar Tütüncü2Claudia Kunze3Cornelia Fiessler4Paulus Kirchhof5Joanna Dietzel6Johannes Schurig7Patrick Oschmann8Ludwig Niehaus9Christian Urbanek10Götz Thomalla11Darius G. Nabavi12Joachim Röther13Ulrich Laufs14Roland Veltkamp15Peter U. Heuschmann16Karl Georg Haeusler17Matthias Endres18for the MonDAFIS InvestigatorsCenter for Stroke Research BerlinCharité—Universitätsmedizin BerlinBerlinGermanyCenter for Stroke Research BerlinCharité—Universitätsmedizin BerlinBerlinGermanyCenter for Stroke Research BerlinCharité—Universitätsmedizin BerlinBerlinGermanyCenter for Stroke Research BerlinCharité—Universitätsmedizin BerlinBerlinGermanyInstitute of Clinical Epidemiology and BiometryJulius‐Maximilians‐Universität WürzburgWürzburg GermanyInstitute of Cardiovascular SciencesUniversity of BirminghamBirminghamUKInstitute of Social Medicine, Epidemiology and Health EconomicsCharité—Universitätsmedizin BerlinBerlinGermanyCenter for Stroke Research BerlinCharité—Universitätsmedizin BerlinBerlinGermanyDepartment of NeurologyHospital BayreuthBayreuthGermanyDepartment of NeurologyRems‐Murr‐Hospital WinnendenWinnenden GermanyDepartment of NeurologyClinical Center of LudwigshafenLudwigshafen GermanyDepartment of NeurologyUniversity Medical Center Hamburg‐EppendorfHamburgGermanyDepartment of NeurologyVivantes Hospital NeuköllnBerlinGermanyDepartment of NeurologyAsklepios Hospital AltonaHamburgGermanyDepartment of CardiologyUniversity HospitalLeipzig UniversityLeipzigGermanyDepartment of NeurologyAlfried Krupp KrankenhausEssenGermanyInstitute of Clinical Epidemiology and BiometryJulius‐Maximilians‐Universität WürzburgWürzburg GermanyDepartment of NeurologyUniversity Hospital UlmUlm GermanyCenter for Stroke Research BerlinCharité—Universitätsmedizin BerlinBerlinGermanyABSTRACT Aims Atrial fibrillation (AF) accounts for about 20% of all ischemic strokes worldwide. It is known that AF impairs health‐related quality of life (HRQOL) in the general population, but data on HRQOL in stroke patients with newly diagnosed AF are sparse. Methods Post hoc analysis of the prospective, investigator‐initiated, multicenter MonDAFIS study (NCT02204267) to analyze whether AF‐related oral anticoagulation (OAC), and/or AF‐symptom severity are associated with HRQOL after ischemic stroke or transient ischemic attack (TIA). HRQOL was measured using the EQ‐5D‐3L‐questionnaire (including EQ‐index/EQ‐VAS) at baseline and after 12 months using multivariable linear mixed models. AF symptom severity was assessed using the European Heart Rhythm Association classification and symptom severity score (EHRA score) categorizing patients with no/mild/severe/disabling AF‐related symptoms. Results A first episode of AF was detected in 261/2927 (8.9%) patients within 12 months after the index stroke and 227/2920 (7.8%) patients had AF and were anticoagulated at 12 months. HRQOL (measured by EQ‐index, n = 2495 patients) was higher in AF patients on OAC compared to AF patients without OAC at 12 months after stroke (mean difference: MD: –16.8, 95% CI: 5.6 to 28.0), and similar in AF patients under OAC compared with patients without AF (MD: 2.0, 95% CI: –2.2 to 6.3). AF‐related symptoms were negatively associated with HRQOL (measured by EQ‐index) indicating that stroke patients with AF‐related symptoms had a lower HRQOL compared to asymptomatic AF patients (mild vs. asymptomatic: MD: –9.0, 95% CI: –17.7 to –0.3; severe/disabling vs. asymptomatic: MD: –19.1, 95% CI: –34.7 to –3.4). Discussion Stroke patients with newly diagnosed AF are at risk of lower quality of life at 12 months, depending on OAC status and AF symptom severity.https://doi.org/10.1002/brb3.70248atrial fibrillationischemic strokeoral anticoagulationquality of lifetransient ischemic attack |
| spellingShingle | Manuel C. Olma Lena Steindorf‐Sabath Serdar Tütüncü Claudia Kunze Cornelia Fiessler Paulus Kirchhof Joanna Dietzel Johannes Schurig Patrick Oschmann Ludwig Niehaus Christian Urbanek Götz Thomalla Darius G. Nabavi Joachim Röther Ulrich Laufs Roland Veltkamp Peter U. Heuschmann Karl Georg Haeusler Matthias Endres for the MonDAFIS Investigators The Role of Atrial Fibrillation and Oral Anticoagulation Status in Health‐Related Quality of Life 12 Months After Ischemic Stroke or TIA Brain and Behavior atrial fibrillation ischemic stroke oral anticoagulation quality of life transient ischemic attack |
| title | The Role of Atrial Fibrillation and Oral Anticoagulation Status in Health‐Related Quality of Life 12 Months After Ischemic Stroke or TIA |
| title_full | The Role of Atrial Fibrillation and Oral Anticoagulation Status in Health‐Related Quality of Life 12 Months After Ischemic Stroke or TIA |
| title_fullStr | The Role of Atrial Fibrillation and Oral Anticoagulation Status in Health‐Related Quality of Life 12 Months After Ischemic Stroke or TIA |
| title_full_unstemmed | The Role of Atrial Fibrillation and Oral Anticoagulation Status in Health‐Related Quality of Life 12 Months After Ischemic Stroke or TIA |
| title_short | The Role of Atrial Fibrillation and Oral Anticoagulation Status in Health‐Related Quality of Life 12 Months After Ischemic Stroke or TIA |
| title_sort | role of atrial fibrillation and oral anticoagulation status in health related quality of life 12 months after ischemic stroke or tia |
| topic | atrial fibrillation ischemic stroke oral anticoagulation quality of life transient ischemic attack |
| url | https://doi.org/10.1002/brb3.70248 |
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