Erythromycin and clarithromycin modulation of growth factor-induced expression of heparanase mRNA on human lung cancer cells in vitro
Heparanase activity is correlated with the metastatic potential of several cancer cells and is a key enzyme in the breakdown of tissue barriers. It is also involved in the regulation of growth factor and cytokine activity. However, little is known about the factors that induce heparanase in cancer c...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2001-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629350120093731 |
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| _version_ | 1832549816636276736 |
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| author | Masahiro Sasaki Takefumi Ito Masayuki Kashima Shin Fukui Noriko Izumiyama Akiko Watanabe Masaaki Sano Yosimasa Fujiwara Mamoru Miura |
| author_facet | Masahiro Sasaki Takefumi Ito Masayuki Kashima Shin Fukui Noriko Izumiyama Akiko Watanabe Masaaki Sano Yosimasa Fujiwara Mamoru Miura |
| author_sort | Masahiro Sasaki |
| collection | DOAJ |
| description | Heparanase activity is correlated with the metastatic potential of several cancer cells and is a key enzyme in the breakdown of tissue barriers. It is also involved in the regulation of growth factor and cytokine activity. However, little is known about the factors that induce heparanase in cancer cells. We investigated the effect of three growth factors, plateletderived growth factor (PDGF), hepatocyte growth factor (HGF) and basic fibroblast growth factor (bFGF), on heparanase mRNA induction in lung cancer cells in vitro. In addition, we examined the effect of erythromycin (EM) and clarithromycin (CAM), which are 14-membered ring macrolide antibiotics that act as biological response modifiers, on the expression of heparanase mRNA induced by growth factors. |
| format | Article |
| id | doaj-art-ad64a58a5f1046d7b18473e8355608b9 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2001-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-ad64a58a5f1046d7b18473e8355608b92025-02-03T06:08:29ZengWileyMediators of Inflammation0962-93511466-18612001-01-0110525926710.1080/09629350120093731Erythromycin and clarithromycin modulation of growth factor-induced expression of heparanase mRNA on human lung cancer cells in vitroMasahiro Sasaki0Takefumi Ito1Masayuki Kashima2Shin Fukui3Noriko Izumiyama4Akiko Watanabe5Masaaki Sano6Yosimasa Fujiwara7Mamoru Miura8Second Department of Internal Medicine, Akita University School of Medicine, 1–1–1 Hondo, Akita 010, JapanSecond Department of Internal Medicine, Akita University School of Medicine, 1–1–1 Hondo, Akita 010, JapanSecond Department of Internal Medicine, Akita University School of Medicine, 1–1–1 Hondo, Akita 010, JapanSecond Department of Internal Medicine, Akita University School of Medicine, 1–1–1 Hondo, Akita 010, JapanSecond Department of Internal Medicine, Akita University School of Medicine, 1–1–1 Hondo, Akita 010, JapanSecond Department of Internal Medicine, Akita University School of Medicine, 1–1–1 Hondo, Akita 010, JapanSecond Department of Internal Medicine, Akita University School of Medicine, 1–1–1 Hondo, Akita 010, JapanSecond Department of Internal Medicine, Akita University School of Medicine, 1–1–1 Hondo, Akita 010, JapanSecond Department of Internal Medicine, Akita University School of Medicine, 1–1–1 Hondo, Akita 010, JapanHeparanase activity is correlated with the metastatic potential of several cancer cells and is a key enzyme in the breakdown of tissue barriers. It is also involved in the regulation of growth factor and cytokine activity. However, little is known about the factors that induce heparanase in cancer cells. We investigated the effect of three growth factors, plateletderived growth factor (PDGF), hepatocyte growth factor (HGF) and basic fibroblast growth factor (bFGF), on heparanase mRNA induction in lung cancer cells in vitro. In addition, we examined the effect of erythromycin (EM) and clarithromycin (CAM), which are 14-membered ring macrolide antibiotics that act as biological response modifiers, on the expression of heparanase mRNA induced by growth factors.http://dx.doi.org/10.1080/09629350120093731 |
| spellingShingle | Masahiro Sasaki Takefumi Ito Masayuki Kashima Shin Fukui Noriko Izumiyama Akiko Watanabe Masaaki Sano Yosimasa Fujiwara Mamoru Miura Erythromycin and clarithromycin modulation of growth factor-induced expression of heparanase mRNA on human lung cancer cells in vitro Mediators of Inflammation |
| title | Erythromycin and clarithromycin modulation of growth factor-induced expression of heparanase mRNA on human lung cancer cells in vitro |
| title_full | Erythromycin and clarithromycin modulation of growth factor-induced expression of heparanase mRNA on human lung cancer cells in vitro |
| title_fullStr | Erythromycin and clarithromycin modulation of growth factor-induced expression of heparanase mRNA on human lung cancer cells in vitro |
| title_full_unstemmed | Erythromycin and clarithromycin modulation of growth factor-induced expression of heparanase mRNA on human lung cancer cells in vitro |
| title_short | Erythromycin and clarithromycin modulation of growth factor-induced expression of heparanase mRNA on human lung cancer cells in vitro |
| title_sort | erythromycin and clarithromycin modulation of growth factor induced expression of heparanase mrna on human lung cancer cells in vitro |
| url | http://dx.doi.org/10.1080/09629350120093731 |
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