A nonlinear correlation between the serum uric acid to creatinine ratio and the prevalence of hypertension: a large cross-sectional population-based study
Objective To explore the relationship between the serum uric acid to creatinine (UA/Cr) ratio and the prevalence of hypertension.Methods In this cross-sectional study, we included 8571 individuals from the China Health and Nutrition Survey. Logistic regression analysis and restricted cubic spline (R...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2296002 |
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| author | Ru Wang Shuxing Wu Jing Wang Wenting Li Jian Cui Zhuhua Yao |
| author_facet | Ru Wang Shuxing Wu Jing Wang Wenting Li Jian Cui Zhuhua Yao |
| author_sort | Ru Wang |
| collection | DOAJ |
| description | Objective To explore the relationship between the serum uric acid to creatinine (UA/Cr) ratio and the prevalence of hypertension.Methods In this cross-sectional study, we included 8571 individuals from the China Health and Nutrition Survey. Logistic regression analysis and restricted cubic spline (RCS) were used to analyze the relationship between the UA/Cr ratio and hypertension.Results Compared with individuals without hypertension, individuals with hypertension had higher UA/Cr ratios. Multivariate logistic regression analysis showed that a higher UA/Cr ratio was closely related to a higher risk of hypertension (as a continuous variable, OR: 1.054, 95% CI: 1.014-1.095, p = 0.007; as a categorical variable, Q3 vs. Q1, OR: 1.183, 95% CI: 1.011-1.384, p = 0.035; Q4 vs. Q1, OR: 1.347, 95% CI: 1.146-1.582, p < 0.001). Subgroup analysis revealed that the correlation between the UA/Cr ratio and hypertension risk was stable in all subgroups except for the subgroup with diabetes and the subgroup with a BMI ≥ 28 kg/m2 (p < 0.05). Sensitivity analysis confirmed the robustness of the relationship between a higher UA/Cr ratio and a higher risk of hypertension (p < 0.05). The RCS showed that the UA/Cr ratio was nonlinearly related to hypertension risk. Further threshold effect showed that only a UA/Cr ratio less than 5.0 was related to hypertension risk (OR: 1.178, 95% CI: 1.086-1.278, p < 0.001), and the 2-piecewise linear regression model was superior to the 1-line linear regression model (p < 0.05).Conclusion The UA/Cr ratio was associated with the prevalence of hypertension. |
| format | Article |
| id | doaj-art-ad647db9148941a091ce84c0cb970971 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-ad647db9148941a091ce84c0cb9709712025-01-23T04:17:48ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2023.2296002A nonlinear correlation between the serum uric acid to creatinine ratio and the prevalence of hypertension: a large cross-sectional population-based studyRu Wang0Shuxing Wu1Jing Wang2Wenting Li3Jian Cui4Zhuhua Yao5Department of Cardiology, Tianjin Union Medical Center, Tianjin, ChinaDepartment of Cardiology, Tianjin Union Medical Center, Tianjin, ChinaDepartment of Cardiology, Tianjin Union Medical Center, Tianjin, ChinaDepartment of Cardiology, Tianjin Union Medical Center, Tianjin, ChinaDepartment of Cardiology, Tianjin Union Medical Center, Tianjin, ChinaDepartment of Cardiology, Tianjin Union Medical Center, Tianjin, ChinaObjective To explore the relationship between the serum uric acid to creatinine (UA/Cr) ratio and the prevalence of hypertension.Methods In this cross-sectional study, we included 8571 individuals from the China Health and Nutrition Survey. Logistic regression analysis and restricted cubic spline (RCS) were used to analyze the relationship between the UA/Cr ratio and hypertension.Results Compared with individuals without hypertension, individuals with hypertension had higher UA/Cr ratios. Multivariate logistic regression analysis showed that a higher UA/Cr ratio was closely related to a higher risk of hypertension (as a continuous variable, OR: 1.054, 95% CI: 1.014-1.095, p = 0.007; as a categorical variable, Q3 vs. Q1, OR: 1.183, 95% CI: 1.011-1.384, p = 0.035; Q4 vs. Q1, OR: 1.347, 95% CI: 1.146-1.582, p < 0.001). Subgroup analysis revealed that the correlation between the UA/Cr ratio and hypertension risk was stable in all subgroups except for the subgroup with diabetes and the subgroup with a BMI ≥ 28 kg/m2 (p < 0.05). Sensitivity analysis confirmed the robustness of the relationship between a higher UA/Cr ratio and a higher risk of hypertension (p < 0.05). The RCS showed that the UA/Cr ratio was nonlinearly related to hypertension risk. Further threshold effect showed that only a UA/Cr ratio less than 5.0 was related to hypertension risk (OR: 1.178, 95% CI: 1.086-1.278, p < 0.001), and the 2-piecewise linear regression model was superior to the 1-line linear regression model (p < 0.05).Conclusion The UA/Cr ratio was associated with the prevalence of hypertension.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2296002Serum uric acid to creatinine ratioserum uric acidcreatininehypertensionnonlinearity |
| spellingShingle | Ru Wang Shuxing Wu Jing Wang Wenting Li Jian Cui Zhuhua Yao A nonlinear correlation between the serum uric acid to creatinine ratio and the prevalence of hypertension: a large cross-sectional population-based study Renal Failure Serum uric acid to creatinine ratio serum uric acid creatinine hypertension nonlinearity |
| title | A nonlinear correlation between the serum uric acid to creatinine ratio and the prevalence of hypertension: a large cross-sectional population-based study |
| title_full | A nonlinear correlation between the serum uric acid to creatinine ratio and the prevalence of hypertension: a large cross-sectional population-based study |
| title_fullStr | A nonlinear correlation between the serum uric acid to creatinine ratio and the prevalence of hypertension: a large cross-sectional population-based study |
| title_full_unstemmed | A nonlinear correlation between the serum uric acid to creatinine ratio and the prevalence of hypertension: a large cross-sectional population-based study |
| title_short | A nonlinear correlation between the serum uric acid to creatinine ratio and the prevalence of hypertension: a large cross-sectional population-based study |
| title_sort | nonlinear correlation between the serum uric acid to creatinine ratio and the prevalence of hypertension a large cross sectional population based study |
| topic | Serum uric acid to creatinine ratio serum uric acid creatinine hypertension nonlinearity |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2296002 |
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