Anti-Apolipoprotein A-1 IgG Levels Predict Coronary Artery Calcification in Obese but Otherwise Healthy Individuals
We aimed at determining whether anti-apolipoprotein (apo) A-1 IgG levels are independent predictors of coronary artery calcification (CAC) and coronary endothelial dysfunction in obese and nonobese subjects without cardiovascular disease. 48 nonobese and 43 obese subjects were included. CAC score wa...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/243158 |
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| author | Alessandra Quercioli Fabrizio Montecucco Katia Galan Osman Ratib Pascale Roux-Lombard Sabrina Pagano François Mach Thomas H. Schindler Nicolas Vuilleumier |
| author_facet | Alessandra Quercioli Fabrizio Montecucco Katia Galan Osman Ratib Pascale Roux-Lombard Sabrina Pagano François Mach Thomas H. Schindler Nicolas Vuilleumier |
| author_sort | Alessandra Quercioli |
| collection | DOAJ |
| description | We aimed at determining whether anti-apolipoprotein (apo) A-1 IgG levels are independent predictors of coronary artery calcification (CAC) and coronary endothelial dysfunction in obese and nonobese subjects without cardiovascular disease. 48 nonobese and 43 obese subjects were included. CAC score was measured by thorax scanner and defined by an Agatston score > 0. Coronary endothelial dysfunction was determined by measuring myocardial blood flow responses to cold pressor test (CPT) on PET/CT. Serum anti-apoA-1 IgG levels were measured by ELISA. Prevalence of coronary calcification was similar between the two study groups, but the prevalence of coronary endothelial dysfunction was higher in obese subjects. Anti-apoA-1 IgG levels and positivity rate were higher in obese than in nonobese individuals. CAC score was higher in anti-apoA-1 IgG positive subjects. ROC analyses indicated that anti-apoA-1 IgG levels were significant predictors of CAC > 0, but not of coronary endothelial dysfunction with a negative predictive value of 94%. Anti-apoA-1 IgG positivity was associated with a 17-fold independent increased risk of CAC > 0. In conclusion, those preliminary results indicate that anti-apoA-1 IgG autoantibodies are raised in obese subjects and independently predict the presence of coronary calcification in this population but not the presence of coronary endothelial dysfunction. |
| format | Article |
| id | doaj-art-ad60ec3a493b4d62a4f562c2fed7ade8 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-ad60ec3a493b4d62a4f562c2fed7ade82025-02-03T05:44:06ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/243158243158Anti-Apolipoprotein A-1 IgG Levels Predict Coronary Artery Calcification in Obese but Otherwise Healthy IndividualsAlessandra Quercioli0Fabrizio Montecucco1Katia Galan2Osman Ratib3Pascale Roux-Lombard4Sabrina Pagano5François Mach6Thomas H. Schindler7Nicolas Vuilleumier8Division of Cardiology, Department of Medical Specialties, Geneva University Hospitals and University of Geneva, 4 Rue Gabrielle Perret-Gentil, 1211 Geneva, SwitzerlandDivision of Cardiology, Department of Medical Specialties, Geneva University Hospitals and University of Geneva, 4 Rue Gabrielle Perret-Gentil, 1211 Geneva, SwitzerlandDivision of Cardiology, Department of Medical Specialties, Geneva University Hospitals and University of Geneva, 4 Rue Gabrielle Perret-Gentil, 1211 Geneva, SwitzerlandDivision of Nuclear Medicine, Geneva University Hospitals, 4 Rue Gabrielle Perret-Gentil, 1211 Geneva, SwitzerlandDivision of Laboratory Medicine, Department of Genetics and Laboratory Medicine, Geneva University Hospitals, 4 Rue Gabrielle Perret-Gentil, 1211 Geneva, SwitzerlandDivision of Laboratory Medicine, Department of Genetics and Laboratory Medicine, Geneva University Hospitals, 4 Rue Gabrielle Perret-Gentil, 1211 Geneva, SwitzerlandDivision of Cardiology, Department of Medical Specialties, Geneva University Hospitals and University of Geneva, 4 Rue Gabrielle Perret-Gentil, 1211 Geneva, SwitzerlandDivision of Cardiology, Department of Medical Specialties, Geneva University Hospitals and University of Geneva, 4 Rue Gabrielle Perret-Gentil, 1211 Geneva, SwitzerlandDivision of Laboratory Medicine, Department of Genetics and Laboratory Medicine, Geneva University Hospitals, 4 Rue Gabrielle Perret-Gentil, 1211 Geneva, SwitzerlandWe aimed at determining whether anti-apolipoprotein (apo) A-1 IgG levels are independent predictors of coronary artery calcification (CAC) and coronary endothelial dysfunction in obese and nonobese subjects without cardiovascular disease. 48 nonobese and 43 obese subjects were included. CAC score was measured by thorax scanner and defined by an Agatston score > 0. Coronary endothelial dysfunction was determined by measuring myocardial blood flow responses to cold pressor test (CPT) on PET/CT. Serum anti-apoA-1 IgG levels were measured by ELISA. Prevalence of coronary calcification was similar between the two study groups, but the prevalence of coronary endothelial dysfunction was higher in obese subjects. Anti-apoA-1 IgG levels and positivity rate were higher in obese than in nonobese individuals. CAC score was higher in anti-apoA-1 IgG positive subjects. ROC analyses indicated that anti-apoA-1 IgG levels were significant predictors of CAC > 0, but not of coronary endothelial dysfunction with a negative predictive value of 94%. Anti-apoA-1 IgG positivity was associated with a 17-fold independent increased risk of CAC > 0. In conclusion, those preliminary results indicate that anti-apoA-1 IgG autoantibodies are raised in obese subjects and independently predict the presence of coronary calcification in this population but not the presence of coronary endothelial dysfunction.http://dx.doi.org/10.1155/2012/243158 |
| spellingShingle | Alessandra Quercioli Fabrizio Montecucco Katia Galan Osman Ratib Pascale Roux-Lombard Sabrina Pagano François Mach Thomas H. Schindler Nicolas Vuilleumier Anti-Apolipoprotein A-1 IgG Levels Predict Coronary Artery Calcification in Obese but Otherwise Healthy Individuals Mediators of Inflammation |
| title | Anti-Apolipoprotein A-1 IgG Levels Predict Coronary Artery Calcification in Obese but Otherwise Healthy Individuals |
| title_full | Anti-Apolipoprotein A-1 IgG Levels Predict Coronary Artery Calcification in Obese but Otherwise Healthy Individuals |
| title_fullStr | Anti-Apolipoprotein A-1 IgG Levels Predict Coronary Artery Calcification in Obese but Otherwise Healthy Individuals |
| title_full_unstemmed | Anti-Apolipoprotein A-1 IgG Levels Predict Coronary Artery Calcification in Obese but Otherwise Healthy Individuals |
| title_short | Anti-Apolipoprotein A-1 IgG Levels Predict Coronary Artery Calcification in Obese but Otherwise Healthy Individuals |
| title_sort | anti apolipoprotein a 1 igg levels predict coronary artery calcification in obese but otherwise healthy individuals |
| url | http://dx.doi.org/10.1155/2012/243158 |
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