Analysis of vaginal microbiota before and after treatment of high-grade squamous intraepithelial lesions of the uterine cervix
Abstract Objective: HPV infection is considered the most common sexually transmitted virus today. The persistence of HPV is the main cause for the development of precursor lesions and cervical cancer. There are environmental and non-environmental factors that contribute to the persistence of the vi...
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Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
2025-01-01
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| Series: | Revista Brasileira de Ginecologia e Obstetrícia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032024000100262&lng=en&tlng=en |
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| author | Patrícia Mendonça Ventura Isabel Cristina Chulvis do Val Guimarães Luis Guillermo Coca Velarde Susana Cristina Aidé Viviani Fialho Douglas Guedes Ferreira Matheus Madureira Fernandes Rafael Augusto Chaves Machado |
| author_facet | Patrícia Mendonça Ventura Isabel Cristina Chulvis do Val Guimarães Luis Guillermo Coca Velarde Susana Cristina Aidé Viviani Fialho Douglas Guedes Ferreira Matheus Madureira Fernandes Rafael Augusto Chaves Machado |
| author_sort | Patrícia Mendonça Ventura |
| collection | DOAJ |
| description | Abstract Objective: HPV infection is considered the most common sexually transmitted virus today. The persistence of HPV is the main cause for the development of precursor lesions and cervical cancer. There are environmental and non-environmental factors that contribute to the persistence of the virus. Studies indicate a possible relationship between the vaginal microbiota (environmental factor) and the risk of high-grade cervical squamous intraepithelial lesions and cervical cancer. This study evaluates the association between the type of vaginal microbiota and the occurrence of high-grade squamous intraepithelial lesions of the cervix. Methods: Observational, longitudinal, prospective, and analytical studies carried out between 2019 and 2021, which evaluated the vaginal microbiota of patients diagnosed with high-grade cervical squamous intraepithelial lesion before and after treatment in two collections with an interval of 6 months, using scrapings and vaginal swabs. Results: In Group I (with lesions) 28 women participated and 29 in Group II (without lesions). According to Nugent, in the initial collection of Group I, 16 women (57%) had lactobacillary microbiota, eight (28%) intermediate, and four (14%) coccus. In Group II, twenty-one (75%) were lactobacillary, one (3%) was intermediate, and seven (24%) werecoccus. With p=0.03. Conclusion: According to Nugent's criteria, there was an association between the type of vaginal microbiota and the occurrence of high-grade cervical squamous intraepithelial lesions of the cervix. The same was not observed in the Donders classification. Studies with a larger sample are needed to confirm our results. |
| format | Article |
| id | doaj-art-ad5889983e3a441fa5a1c51cdb223ec6 |
| institution | Kabale University |
| issn | 0100-7203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
| record_format | Article |
| series | Revista Brasileira de Ginecologia e Obstetrícia |
| spelling | doaj-art-ad5889983e3a441fa5a1c51cdb223ec62025-01-21T07:36:01ZengFederação Brasileira das Sociedades de Ginecologia e ObstetríciaRevista Brasileira de Ginecologia e Obstetrícia0100-72032025-01-014610.61622/rbgo/2024rbgo86Analysis of vaginal microbiota before and after treatment of high-grade squamous intraepithelial lesions of the uterine cervixPatrícia Mendonça Venturahttps://orcid.org/0000-0002-2758-4136Isabel Cristina Chulvis do Val Guimarãeshttps://orcid.org/0000-0002-9011-4428Luis Guillermo Coca Velardehttps://orcid.org/0000-0003-3110-5270Susana Cristina Aidé Viviani Fialhohttps://orcid.org/0000-0002-4212-0022Douglas Guedes Ferreirahttps://orcid.org/0000-0002-9610-5100Matheus Madureira Fernandeshttps://orcid.org/0009-0007-5839-892XRafael Augusto Chaves Machadohttps://orcid.org/0009-0003-5999-4476Abstract Objective: HPV infection is considered the most common sexually transmitted virus today. The persistence of HPV is the main cause for the development of precursor lesions and cervical cancer. There are environmental and non-environmental factors that contribute to the persistence of the virus. Studies indicate a possible relationship between the vaginal microbiota (environmental factor) and the risk of high-grade cervical squamous intraepithelial lesions and cervical cancer. This study evaluates the association between the type of vaginal microbiota and the occurrence of high-grade squamous intraepithelial lesions of the cervix. Methods: Observational, longitudinal, prospective, and analytical studies carried out between 2019 and 2021, which evaluated the vaginal microbiota of patients diagnosed with high-grade cervical squamous intraepithelial lesion before and after treatment in two collections with an interval of 6 months, using scrapings and vaginal swabs. Results: In Group I (with lesions) 28 women participated and 29 in Group II (without lesions). According to Nugent, in the initial collection of Group I, 16 women (57%) had lactobacillary microbiota, eight (28%) intermediate, and four (14%) coccus. In Group II, twenty-one (75%) were lactobacillary, one (3%) was intermediate, and seven (24%) werecoccus. With p=0.03. Conclusion: According to Nugent's criteria, there was an association between the type of vaginal microbiota and the occurrence of high-grade cervical squamous intraepithelial lesions of the cervix. The same was not observed in the Donders classification. Studies with a larger sample are needed to confirm our results.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032024000100262&lng=en&tlng=enUterine cervical neoplasmsCervixuteriPapillomavirus infectionsMicrobiotaVaginosis, bacterialSquamous intraepithelial lesions of the cervix |
| spellingShingle | Patrícia Mendonça Ventura Isabel Cristina Chulvis do Val Guimarães Luis Guillermo Coca Velarde Susana Cristina Aidé Viviani Fialho Douglas Guedes Ferreira Matheus Madureira Fernandes Rafael Augusto Chaves Machado Analysis of vaginal microbiota before and after treatment of high-grade squamous intraepithelial lesions of the uterine cervix Revista Brasileira de Ginecologia e Obstetrícia Uterine cervical neoplasms Cervixuteri Papillomavirus infections Microbiota Vaginosis, bacterial Squamous intraepithelial lesions of the cervix |
| title | Analysis of vaginal microbiota before and after treatment of high-grade squamous intraepithelial lesions of the uterine cervix |
| title_full | Analysis of vaginal microbiota before and after treatment of high-grade squamous intraepithelial lesions of the uterine cervix |
| title_fullStr | Analysis of vaginal microbiota before and after treatment of high-grade squamous intraepithelial lesions of the uterine cervix |
| title_full_unstemmed | Analysis of vaginal microbiota before and after treatment of high-grade squamous intraepithelial lesions of the uterine cervix |
| title_short | Analysis of vaginal microbiota before and after treatment of high-grade squamous intraepithelial lesions of the uterine cervix |
| title_sort | analysis of vaginal microbiota before and after treatment of high grade squamous intraepithelial lesions of the uterine cervix |
| topic | Uterine cervical neoplasms Cervixuteri Papillomavirus infections Microbiota Vaginosis, bacterial Squamous intraepithelial lesions of the cervix |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032024000100262&lng=en&tlng=en |
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