Enhanced compressive strength and in vitro degradation of porous pectin/ calcium phosphate cement scaffolds by freeze casting without sintered
The development of biodegradable bone scaffolds that align with the growth cycle of new bone has become a prominent focus in the field of bone defect repair. The sintered porous hydroxyapatite scaffolds exhibit a high degree of crystallization and demonstrate a slow degradation rate following implan...
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Elsevier
2025-01-01
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| Series: | Journal of Materials Research and Technology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2238785424028643 |
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| author | Hao Zhang Yufei Tang Xuan Zhou Qian Liang Yani Sun Bo Zhang Kang Zhao Zixiang Wu |
| author_facet | Hao Zhang Yufei Tang Xuan Zhou Qian Liang Yani Sun Bo Zhang Kang Zhao Zixiang Wu |
| author_sort | Hao Zhang |
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| description | The development of biodegradable bone scaffolds that align with the growth cycle of new bone has become a prominent focus in the field of bone defect repair. The sintered porous hydroxyapatite scaffolds exhibit a high degree of crystallization and demonstrate a slow degradation rate following implantation. The apatite phase with low crystallinity can be obtained following the hydration reaction of the non-sintered calcium phosphate bone cement (CPC) scaffolds. However, this leads to the formation of a weak alkaline environment during degradation, ultimately resulting in unsustainable degradation. The present study focuses on the fabrication of porous pectin/CPC composite scaffolds through two approaches during the preparation process of non-sintered porous CPC scaffolds: uniform composite and surface modification. The degradation performance of porous composite scaffolds exhibited an increase with the rise in pectin content. At a pectin content of 70 mg/mL, the scaffolds demonstrated a degradation rate of 13.79% within a span of 30 days. The mechanical properties of the porous scaffolds were enhanced with an increase in pectin concentration through surface coating. When the pectin concentration was 5 wt%, the scaffold exhibited a compressive strength of 8.72 MPa, an elastic modulus of 0.82 GPa, and experienced a degradation rate of 12.57% after a period of 30 days. The local acidic environment not only facilitates the dissolution of bone-like apatite but also enhances cell proliferation and adhesion. Pectin/apatite porous scaffolds exhibit excellent biocompatibility, offering a novel approach for the development of biodegradable bone replacement scaffolds. |
| format | Article |
| id | doaj-art-ad56d49b5aed4a599080f88f6f7c8de7 |
| institution | Kabale University |
| issn | 2238-7854 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | Journal of Materials Research and Technology |
| spelling | doaj-art-ad56d49b5aed4a599080f88f6f7c8de72025-01-19T06:25:14ZengElsevierJournal of Materials Research and Technology2238-78542025-01-0134125135Enhanced compressive strength and in vitro degradation of porous pectin/ calcium phosphate cement scaffolds by freeze casting without sinteredHao Zhang0Yufei Tang1Xuan Zhou2Qian Liang3Yani Sun4Bo Zhang5Kang Zhao6Zixiang Wu7Shaanxi Province Key Laboratory of Corrosion and Protection, Department of Materials Science and Engineering, Xi'an University of Technology, Xi'an, 710048, PR ChinaShaanxi Province Key Laboratory of Corrosion and Protection, Department of Materials Science and Engineering, Xi'an University of Technology, Xi'an, 710048, PR China; Corresponding author. Shaanxi Province Key Laboratory of Corrosion and Protection, Department of Materials Science and Engineering, Xi'an University of Technology, Xi'an, 710048, PR China.Shaanxi Province Key Laboratory of Corrosion and Protection, Department of Materials Science and Engineering, Xi'an University of Technology, Xi'an, 710048, PR ChinaShaanxi Province Key Laboratory of Corrosion and Protection, Department of Materials Science and Engineering, Xi'an University of Technology, Xi'an, 710048, PR ChinaShaanxi Province Key Laboratory of Corrosion and Protection, Department of Materials Science and Engineering, Xi'an University of Technology, Xi'an, 710048, PR ChinaShaanxi Province Key Laboratory of Corrosion and Protection, Department of Materials Science and Engineering, Xi'an University of Technology, Xi'an, 710048, PR ChinaShaanxi Province Key Laboratory of Corrosion and Protection, Department of Materials Science and Engineering, Xi'an University of Technology, Xi'an, 710048, PR ChinaShaanxi Province Key Laboratory of Corrosion and Protection, Department of Materials Science and Engineering, Xi'an University of Technology, Xi'an, 710048, PR China; Institute of Orthopaedics, Xi’Jing Hospital, Air Force Medical University, Xi'an, 710032, PR China; Corresponding author. Institute of Orthopaedics, Xi’Jing Hospital, Air Force Medical University, Xi'an, 710032, PR China.The development of biodegradable bone scaffolds that align with the growth cycle of new bone has become a prominent focus in the field of bone defect repair. The sintered porous hydroxyapatite scaffolds exhibit a high degree of crystallization and demonstrate a slow degradation rate following implantation. The apatite phase with low crystallinity can be obtained following the hydration reaction of the non-sintered calcium phosphate bone cement (CPC) scaffolds. However, this leads to the formation of a weak alkaline environment during degradation, ultimately resulting in unsustainable degradation. The present study focuses on the fabrication of porous pectin/CPC composite scaffolds through two approaches during the preparation process of non-sintered porous CPC scaffolds: uniform composite and surface modification. The degradation performance of porous composite scaffolds exhibited an increase with the rise in pectin content. At a pectin content of 70 mg/mL, the scaffolds demonstrated a degradation rate of 13.79% within a span of 30 days. The mechanical properties of the porous scaffolds were enhanced with an increase in pectin concentration through surface coating. When the pectin concentration was 5 wt%, the scaffold exhibited a compressive strength of 8.72 MPa, an elastic modulus of 0.82 GPa, and experienced a degradation rate of 12.57% after a period of 30 days. The local acidic environment not only facilitates the dissolution of bone-like apatite but also enhances cell proliferation and adhesion. Pectin/apatite porous scaffolds exhibit excellent biocompatibility, offering a novel approach for the development of biodegradable bone replacement scaffolds.http://www.sciencedirect.com/science/article/pii/S2238785424028643Sinterless porous composite scaffoldsPectin/ calcium phosphate cementFreeze castingDegradation behaviorBiocompatibility |
| spellingShingle | Hao Zhang Yufei Tang Xuan Zhou Qian Liang Yani Sun Bo Zhang Kang Zhao Zixiang Wu Enhanced compressive strength and in vitro degradation of porous pectin/ calcium phosphate cement scaffolds by freeze casting without sintered Journal of Materials Research and Technology Sinterless porous composite scaffolds Pectin/ calcium phosphate cement Freeze casting Degradation behavior Biocompatibility |
| title | Enhanced compressive strength and in vitro degradation of porous pectin/ calcium phosphate cement scaffolds by freeze casting without sintered |
| title_full | Enhanced compressive strength and in vitro degradation of porous pectin/ calcium phosphate cement scaffolds by freeze casting without sintered |
| title_fullStr | Enhanced compressive strength and in vitro degradation of porous pectin/ calcium phosphate cement scaffolds by freeze casting without sintered |
| title_full_unstemmed | Enhanced compressive strength and in vitro degradation of porous pectin/ calcium phosphate cement scaffolds by freeze casting without sintered |
| title_short | Enhanced compressive strength and in vitro degradation of porous pectin/ calcium phosphate cement scaffolds by freeze casting without sintered |
| title_sort | enhanced compressive strength and in vitro degradation of porous pectin calcium phosphate cement scaffolds by freeze casting without sintered |
| topic | Sinterless porous composite scaffolds Pectin/ calcium phosphate cement Freeze casting Degradation behavior Biocompatibility |
| url | http://www.sciencedirect.com/science/article/pii/S2238785424028643 |
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