Research progress on effect of ambient particulate matters on Alzheimer's disease and potential mechanisms
With the accelerating aging of world population, the prevalence and disease burden of dementia such as Alzheimer's disease is increasing annually. As one of the major risk factors for dementia, air pollution is still an urgent global concern. Studies on the association between ambient particula...
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| Format: | Article |
| Language: | English |
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Editorial Committee of Journal of Environmental and Occupational Medicine
2025-06-01
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| Series: | 环境与职业医学 |
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| Online Access: | http://www.jeom.org/article/cn/10.11836/JEOM25012 |
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| author | Lu YU Chihang ZHANG Jianshu GUO Dongxia FAN Jinzhuo ZHAO |
| author_facet | Lu YU Chihang ZHANG Jianshu GUO Dongxia FAN Jinzhuo ZHAO |
| author_sort | Lu YU |
| collection | DOAJ |
| description | With the accelerating aging of world population, the prevalence and disease burden of dementia such as Alzheimer's disease is increasing annually. As one of the major risk factors for dementia, air pollution is still an urgent global concern. Studies on the association between ambient particulate matter (PM), one of the major air pollutants, and dementia, such as Alzheimer's disease, are gaining attention. This paper reviewed the current evidence of relevant epidemiological and toxicological studies to illustrate the possible mechanisms underlying the effects of PM exposure on Alzheimer's disease through inflammatory responses, oxidative stress, endocrine disruption, excitatory neurotoxicity, glial cell activation, and intestinal flora disruption, which may provide clues for mitigating the health risks of air pollution and preventing Alzheimer's disease. |
| format | Article |
| id | doaj-art-ad4f5bb95fc14e9c8fffa3c843e09d6b |
| institution | Kabale University |
| issn | 2095-9982 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Editorial Committee of Journal of Environmental and Occupational Medicine |
| record_format | Article |
| series | 环境与职业医学 |
| spelling | doaj-art-ad4f5bb95fc14e9c8fffa3c843e09d6b2025-08-20T03:50:06ZengEditorial Committee of Journal of Environmental and Occupational Medicine环境与职业医学2095-99822025-06-0142674875510.11836/JEOM2501225012Research progress on effect of ambient particulate matters on Alzheimer's disease and potential mechanismsLu YU0Chihang ZHANG1Jianshu GUO2Dongxia FAN3Jinzhuo ZHAO4Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200030, ChinaDepartment of Environmental Health, School of Public Health, Fudan University, Shanghai 200030, ChinaDepartment of Environmental Health, School of Public Health, Fudan University, Shanghai 200030, ChinaDepartment of Environmental Health, School of Public Health, Fudan University, Shanghai 200030, ChinaDepartment of Environmental Health, School of Public Health, Fudan University, Shanghai 200030, ChinaWith the accelerating aging of world population, the prevalence and disease burden of dementia such as Alzheimer's disease is increasing annually. As one of the major risk factors for dementia, air pollution is still an urgent global concern. Studies on the association between ambient particulate matter (PM), one of the major air pollutants, and dementia, such as Alzheimer's disease, are gaining attention. This paper reviewed the current evidence of relevant epidemiological and toxicological studies to illustrate the possible mechanisms underlying the effects of PM exposure on Alzheimer's disease through inflammatory responses, oxidative stress, endocrine disruption, excitatory neurotoxicity, glial cell activation, and intestinal flora disruption, which may provide clues for mitigating the health risks of air pollution and preventing Alzheimer's disease.http://www.jeom.org/article/cn/10.11836/JEOM25012ambient particulate matteralzheimer's diseasemechanism of injuryepidemiologytoxicology |
| spellingShingle | Lu YU Chihang ZHANG Jianshu GUO Dongxia FAN Jinzhuo ZHAO Research progress on effect of ambient particulate matters on Alzheimer's disease and potential mechanisms 环境与职业医学 ambient particulate matter alzheimer's disease mechanism of injury epidemiology toxicology |
| title | Research progress on effect of ambient particulate matters on Alzheimer's disease and potential mechanisms |
| title_full | Research progress on effect of ambient particulate matters on Alzheimer's disease and potential mechanisms |
| title_fullStr | Research progress on effect of ambient particulate matters on Alzheimer's disease and potential mechanisms |
| title_full_unstemmed | Research progress on effect of ambient particulate matters on Alzheimer's disease and potential mechanisms |
| title_short | Research progress on effect of ambient particulate matters on Alzheimer's disease and potential mechanisms |
| title_sort | research progress on effect of ambient particulate matters on alzheimer s disease and potential mechanisms |
| topic | ambient particulate matter alzheimer's disease mechanism of injury epidemiology toxicology |
| url | http://www.jeom.org/article/cn/10.11836/JEOM25012 |
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