The Impact of Bacterial Dysbiosis on the Development of Pancreatic Cancer and Its Treatment in Humans?
Pancreatic cancer is one of the deadliest types of cancer and is still difficult to treat, despite recent medical advances. Many studies show correlations between the human oral and intestinal microbiota and pancreatic cancer. The mechanism of action of microorganisms on the pancreatic microenvironm...
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| Format: | Article |
| Language: | English |
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Sciendo
2025-07-01
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| Series: | Postępy Mikrobiologii |
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| Online Access: | https://doi.org/10.2478/am-2025-0007 |
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| author | Mikołajczyk Agata Wardak Amelia Głuszek Stanisław Adamus-Białek Wioletta |
| author_facet | Mikołajczyk Agata Wardak Amelia Głuszek Stanisław Adamus-Białek Wioletta |
| author_sort | Mikołajczyk Agata |
| collection | DOAJ |
| description | Pancreatic cancer is one of the deadliest types of cancer and is still difficult to treat, despite recent medical advances. Many studies show correlations between the human oral and intestinal microbiota and pancreatic cancer. The mechanism of action of microorganisms on the pancreatic microenvironment is still not fully understood. The aspect of immune response related to treatment and the microorganisms present has also been addressed. This review presents current evidence on the human microbiota, mainly focusing on its bacterial contribution and influence, and identifies the areas that may benefit most from earlier diagnosis and the potential for less invasive treatment of pancreatic cancer. A review of all the latest literature (n=86) in peer-reviewed English-language journals with an Impact Factor from PubMed (NCBI) and Google Scholar was conducted; most studies concerned the analysis of bacteria in the human microbiota or in a mouse model. |
| format | Article |
| id | doaj-art-ad4f0ef7e4fa4e6f85e9161dce475cfa |
| institution | Kabale University |
| issn | 2545-3149 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Postępy Mikrobiologii |
| spelling | doaj-art-ad4f0ef7e4fa4e6f85e9161dce475cfa2025-08-20T03:59:39ZengSciendoPostępy Mikrobiologii2545-31492025-07-01642748510.2478/am-2025-0007The Impact of Bacterial Dysbiosis on the Development of Pancreatic Cancer and Its Treatment in Humans?Mikołajczyk Agata0Wardak Amelia1Głuszek Stanisław2Adamus-Białek Wioletta3Institute of Medical Sciences, Jan Kochanowski University of Kielce, Av. IX Wieków Kielc 19a, 25-317Kielce, PolandInstitute of Medical Sciences, Jan Kochanowski University of Kielce, Av. IX Wieków Kielc 19a, 25-317Kielce, PolandInstitute of Medical Sciences, Jan Kochanowski University of Kielce, Av. IX Wieków Kielc 19a, 25-317Kielce, PolandInstitute of Medical Sciences, Jan Kochanowski University of Kielce, Av. IX Wieków Kielc 19a, 25-317Kielce, PolandPancreatic cancer is one of the deadliest types of cancer and is still difficult to treat, despite recent medical advances. Many studies show correlations between the human oral and intestinal microbiota and pancreatic cancer. The mechanism of action of microorganisms on the pancreatic microenvironment is still not fully understood. The aspect of immune response related to treatment and the microorganisms present has also been addressed. This review presents current evidence on the human microbiota, mainly focusing on its bacterial contribution and influence, and identifies the areas that may benefit most from earlier diagnosis and the potential for less invasive treatment of pancreatic cancer. A review of all the latest literature (n=86) in peer-reviewed English-language journals with an Impact Factor from PubMed (NCBI) and Google Scholar was conducted; most studies concerned the analysis of bacteria in the human microbiota or in a mouse model.https://doi.org/10.2478/am-2025-0007microbiomepancreastumor |
| spellingShingle | Mikołajczyk Agata Wardak Amelia Głuszek Stanisław Adamus-Białek Wioletta The Impact of Bacterial Dysbiosis on the Development of Pancreatic Cancer and Its Treatment in Humans? Postępy Mikrobiologii microbiome pancreas tumor |
| title | The Impact of Bacterial Dysbiosis on the Development of Pancreatic Cancer and Its Treatment in Humans? |
| title_full | The Impact of Bacterial Dysbiosis on the Development of Pancreatic Cancer and Its Treatment in Humans? |
| title_fullStr | The Impact of Bacterial Dysbiosis on the Development of Pancreatic Cancer and Its Treatment in Humans? |
| title_full_unstemmed | The Impact of Bacterial Dysbiosis on the Development of Pancreatic Cancer and Its Treatment in Humans? |
| title_short | The Impact of Bacterial Dysbiosis on the Development of Pancreatic Cancer and Its Treatment in Humans? |
| title_sort | impact of bacterial dysbiosis on the development of pancreatic cancer and its treatment in humans |
| topic | microbiome pancreas tumor |
| url | https://doi.org/10.2478/am-2025-0007 |
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