Varicella zoster virus triggering Henoch–Schonlein Purpura in an adult: A case report
This case reports highlights a 37-year-old woman who was transferred to Mayo Clinic Arizona for care after development of seizures, altered mental status, and a diffuse petechial rash, along with vesicular lesions near the groin. She received broad-spectrum antimicrobial therapy. CSF testing showed...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | IDCases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214250925000290 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832542466362834944 |
|---|---|
| author | Kevin Chung Natasha Priya Dyal Sandhya Nagarakanti |
| author_facet | Kevin Chung Natasha Priya Dyal Sandhya Nagarakanti |
| author_sort | Kevin Chung |
| collection | DOAJ |
| description | This case reports highlights a 37-year-old woman who was transferred to Mayo Clinic Arizona for care after development of seizures, altered mental status, and a diffuse petechial rash, along with vesicular lesions near the groin. She received broad-spectrum antimicrobial therapy. CSF testing showed lymphocytic pleocytosis and elevated protein levels, and PCR testing confirmed varicella zoster virus (VZV) infection. MRI of the brain demonstrated chronic microhemorrhages, indicative of vasculitis secondary to disseminated VZV. Dermatology consultation and subsequent biopsy of the skin lesions revealed leukocytoclastic vasculitis with IgA deposition, consistent with Henoch-Schonlein Purpura (HSP). A VZV-positive PCR from the rash further corroborated the diagnosis. This case highlights the first reported instance of VZV induced HSP in an adult. Although this patient had no complications from HSP, early recognition and targeted treatment are necessary in some cases to prevent severe conditions. This case underscores the importance of maintaining a broad differential diagnosis and the importance of biopsy lesions for prompt recognition of uncommon conditions in high-risk patients. |
| format | Article |
| id | doaj-art-ad44d76a110c4809ba1d999ab7e262de |
| institution | Kabale University |
| issn | 2214-2509 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IDCases |
| spelling | doaj-art-ad44d76a110c4809ba1d999ab7e262de2025-02-04T04:10:25ZengElsevierIDCases2214-25092025-01-0139e02174Varicella zoster virus triggering Henoch–Schonlein Purpura in an adult: A case reportKevin Chung0Natasha Priya Dyal1Sandhya Nagarakanti2Department of Internal Medicine, Mayo Clinic, Phoenix, AZ, USADivision of Infectious Diseases, Mayo Clinic, Phoenix, AZ, USADivision of Infectious Diseases, Mayo Clinic, Phoenix, AZ, USA; Correspondence to: Mayo Clinic Arizona, Division of Infectious Diseases, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.This case reports highlights a 37-year-old woman who was transferred to Mayo Clinic Arizona for care after development of seizures, altered mental status, and a diffuse petechial rash, along with vesicular lesions near the groin. She received broad-spectrum antimicrobial therapy. CSF testing showed lymphocytic pleocytosis and elevated protein levels, and PCR testing confirmed varicella zoster virus (VZV) infection. MRI of the brain demonstrated chronic microhemorrhages, indicative of vasculitis secondary to disseminated VZV. Dermatology consultation and subsequent biopsy of the skin lesions revealed leukocytoclastic vasculitis with IgA deposition, consistent with Henoch-Schonlein Purpura (HSP). A VZV-positive PCR from the rash further corroborated the diagnosis. This case highlights the first reported instance of VZV induced HSP in an adult. Although this patient had no complications from HSP, early recognition and targeted treatment are necessary in some cases to prevent severe conditions. This case underscores the importance of maintaining a broad differential diagnosis and the importance of biopsy lesions for prompt recognition of uncommon conditions in high-risk patients.http://www.sciencedirect.com/science/article/pii/S2214250925000290VZVRashHSP |
| spellingShingle | Kevin Chung Natasha Priya Dyal Sandhya Nagarakanti Varicella zoster virus triggering Henoch–Schonlein Purpura in an adult: A case report IDCases VZV Rash HSP |
| title | Varicella zoster virus triggering Henoch–Schonlein Purpura in an adult: A case report |
| title_full | Varicella zoster virus triggering Henoch–Schonlein Purpura in an adult: A case report |
| title_fullStr | Varicella zoster virus triggering Henoch–Schonlein Purpura in an adult: A case report |
| title_full_unstemmed | Varicella zoster virus triggering Henoch–Schonlein Purpura in an adult: A case report |
| title_short | Varicella zoster virus triggering Henoch–Schonlein Purpura in an adult: A case report |
| title_sort | varicella zoster virus triggering henoch schonlein purpura in an adult a case report |
| topic | VZV Rash HSP |
| url | http://www.sciencedirect.com/science/article/pii/S2214250925000290 |
| work_keys_str_mv | AT kevinchung varicellazostervirustriggeringhenochschonleinpurpurainanadultacasereport AT natashapriyadyal varicellazostervirustriggeringhenochschonleinpurpurainanadultacasereport AT sandhyanagarakanti varicellazostervirustriggeringhenochschonleinpurpurainanadultacasereport |