Unveiling the role of SYNGR4 in breast cancer development: a novel target for immunotherapy
IntroductionSYNGR4 is considered to be one of the causative genes for amyotrophic lateral sclerosis, but its role in breast cancer development has not been revealed.MethodsThe expression of SYNGR4 in a variety of malignancies including breast cancer was analyzed using Genotype Tissue Expression (GTE...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1490073/full |
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| author | Jie Ma Hongtao Wang Zhengwei Gui Yuanrong Yang |
| author_facet | Jie Ma Hongtao Wang Zhengwei Gui Yuanrong Yang |
| author_sort | Jie Ma |
| collection | DOAJ |
| description | IntroductionSYNGR4 is considered to be one of the causative genes for amyotrophic lateral sclerosis, but its role in breast cancer development has not been revealed.MethodsThe expression of SYNGR4 in a variety of malignancies including breast cancer was analyzed using Genotype Tissue Expression (GTEx) and the Cancer Genome Atlas (TCGA) databases and verified by specimens collected from our center. The effect of SYNGR4 on breast cancer prognosis was analyzed using bioinformatics and possible pathways by which this molecule affects breast cancer prognosis were explored. The effect of SYNGR4 on immune infiltration of breast cancer was analyzed using GSVA, and the effects of SYNGR4 on breast cancer proliferation, migration, and tumor-associated macrophage polarization in cancer foci were verified by cellular and animal experiments, respectively.ResultsSYNGR4 is highly expressed in a variety of malignant tumors, including breast cancer, and affects the prognosis of breast cancer patients. This may be a volatile effect through Organelle fission, chromosome segregation, nuclear division, etc. SYNGR4 overexpression affects breast cancer proliferation, migration, and tumor immune infiltration, and promotes breast cancer tumor-associated macrophage polarization toward M2.DiscussionSYNGR4 overexpression can affect the prognosis of breast cancer patients by promoting M2 polarization of tumor-associated macrophages in breast cancer, and this molecule may be a novel target for breast cancer immunotherapy. |
| format | Article |
| id | doaj-art-ad42fd6d9feb437ea9f02ba67124ba91 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-ad42fd6d9feb437ea9f02ba67124ba912025-01-20T07:20:20ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.14900731490073Unveiling the role of SYNGR4 in breast cancer development: a novel target for immunotherapyJie Ma0Hongtao Wang1Zhengwei Gui2Yuanrong Yang3Department of Mammary, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei, ChinaDepartment of Pharmacy, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei, ChinaDepartment of Thyroid and Breast Surgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, ChinaDepartment of Pharmacy, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei, ChinaIntroductionSYNGR4 is considered to be one of the causative genes for amyotrophic lateral sclerosis, but its role in breast cancer development has not been revealed.MethodsThe expression of SYNGR4 in a variety of malignancies including breast cancer was analyzed using Genotype Tissue Expression (GTEx) and the Cancer Genome Atlas (TCGA) databases and verified by specimens collected from our center. The effect of SYNGR4 on breast cancer prognosis was analyzed using bioinformatics and possible pathways by which this molecule affects breast cancer prognosis were explored. The effect of SYNGR4 on immune infiltration of breast cancer was analyzed using GSVA, and the effects of SYNGR4 on breast cancer proliferation, migration, and tumor-associated macrophage polarization in cancer foci were verified by cellular and animal experiments, respectively.ResultsSYNGR4 is highly expressed in a variety of malignant tumors, including breast cancer, and affects the prognosis of breast cancer patients. This may be a volatile effect through Organelle fission, chromosome segregation, nuclear division, etc. SYNGR4 overexpression affects breast cancer proliferation, migration, and tumor immune infiltration, and promotes breast cancer tumor-associated macrophage polarization toward M2.DiscussionSYNGR4 overexpression can affect the prognosis of breast cancer patients by promoting M2 polarization of tumor-associated macrophages in breast cancer, and this molecule may be a novel target for breast cancer immunotherapy.https://www.frontiersin.org/articles/10.3389/fonc.2024.1490073/fullbreast cancerSYNGR4cell proliferationimmune infiltrationoncogene |
| spellingShingle | Jie Ma Hongtao Wang Zhengwei Gui Yuanrong Yang Unveiling the role of SYNGR4 in breast cancer development: a novel target for immunotherapy Frontiers in Oncology breast cancer SYNGR4 cell proliferation immune infiltration oncogene |
| title | Unveiling the role of SYNGR4 in breast cancer development: a novel target for immunotherapy |
| title_full | Unveiling the role of SYNGR4 in breast cancer development: a novel target for immunotherapy |
| title_fullStr | Unveiling the role of SYNGR4 in breast cancer development: a novel target for immunotherapy |
| title_full_unstemmed | Unveiling the role of SYNGR4 in breast cancer development: a novel target for immunotherapy |
| title_short | Unveiling the role of SYNGR4 in breast cancer development: a novel target for immunotherapy |
| title_sort | unveiling the role of syngr4 in breast cancer development a novel target for immunotherapy |
| topic | breast cancer SYNGR4 cell proliferation immune infiltration oncogene |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1490073/full |
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