Retinal Electrophysiology Is a Viable Preclinical Biomarker for Drug Penetrance into the Central Nervous System
Objective. To examine whether retinal electrophysiology is a useful surrogate marker of drug penetrance into the central nervous system (CNS). Materials and Methods. Brain and retinal electrophysiology were assessed with full-field visually evoked potentials and electroretinograms in conscious and a...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2016/5801826 |
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| author | Jason Charng Zheng He Algis J. Vingrys Rebecca L. Fish Rachel Gurrell Bang V. Bui Christine T. Nguyen |
| author_facet | Jason Charng Zheng He Algis J. Vingrys Rebecca L. Fish Rachel Gurrell Bang V. Bui Christine T. Nguyen |
| author_sort | Jason Charng |
| collection | DOAJ |
| description | Objective. To examine whether retinal electrophysiology is a useful surrogate marker of drug penetrance into the central nervous system (CNS). Materials and Methods. Brain and retinal electrophysiology were assessed with full-field visually evoked potentials and electroretinograms in conscious and anaesthetised rats following systemic or local administrations of centrally penetrant (muscimol) or nonpenetrant (isoguvacine) compounds. Results. Local injections into the eye/brain bypassed the blood neural barriers and produced changes in retinal/brain responses for both drugs. In conscious animals, systemic administration of muscimol resulted in retinal and brain biopotential changes, whereas systemic delivery of isoguvacine did not. General anaesthesia confounded these outcomes. Conclusions. Retinal electrophysiology, when recorded in conscious animals, shows promise as a viable biomarker of drug penetration into the CNS. In contrast, when conducted under anaesthetised conditions confounds can be induced in both cortical and retinal electrophysiological recordings. |
| format | Article |
| id | doaj-art-ad3f51101ff548f78ee0b53b493f9543 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-ad3f51101ff548f78ee0b53b493f95432025-02-03T06:11:23ZengWileyJournal of Ophthalmology2090-004X2090-00582016-01-01201610.1155/2016/58018265801826Retinal Electrophysiology Is a Viable Preclinical Biomarker for Drug Penetrance into the Central Nervous SystemJason Charng0Zheng He1Algis J. Vingrys2Rebecca L. Fish3Rachel Gurrell4Bang V. Bui5Christine T. Nguyen6Department of Optometry & Vision Sciences, University of Melbourne, Parkville, VIC 3010, AustraliaDepartment of Optometry & Vision Sciences, University of Melbourne, Parkville, VIC 3010, AustraliaDepartment of Optometry & Vision Sciences, University of Melbourne, Parkville, VIC 3010, AustraliaPfizer Neusentis, Cambridge CB21 6GS, UKPfizer Neusentis, Cambridge CB21 6GS, UKDepartment of Optometry & Vision Sciences, University of Melbourne, Parkville, VIC 3010, AustraliaDepartment of Optometry & Vision Sciences, University of Melbourne, Parkville, VIC 3010, AustraliaObjective. To examine whether retinal electrophysiology is a useful surrogate marker of drug penetrance into the central nervous system (CNS). Materials and Methods. Brain and retinal electrophysiology were assessed with full-field visually evoked potentials and electroretinograms in conscious and anaesthetised rats following systemic or local administrations of centrally penetrant (muscimol) or nonpenetrant (isoguvacine) compounds. Results. Local injections into the eye/brain bypassed the blood neural barriers and produced changes in retinal/brain responses for both drugs. In conscious animals, systemic administration of muscimol resulted in retinal and brain biopotential changes, whereas systemic delivery of isoguvacine did not. General anaesthesia confounded these outcomes. Conclusions. Retinal electrophysiology, when recorded in conscious animals, shows promise as a viable biomarker of drug penetration into the CNS. In contrast, when conducted under anaesthetised conditions confounds can be induced in both cortical and retinal electrophysiological recordings.http://dx.doi.org/10.1155/2016/5801826 |
| spellingShingle | Jason Charng Zheng He Algis J. Vingrys Rebecca L. Fish Rachel Gurrell Bang V. Bui Christine T. Nguyen Retinal Electrophysiology Is a Viable Preclinical Biomarker for Drug Penetrance into the Central Nervous System Journal of Ophthalmology |
| title | Retinal Electrophysiology Is a Viable Preclinical Biomarker for Drug Penetrance into the Central Nervous System |
| title_full | Retinal Electrophysiology Is a Viable Preclinical Biomarker for Drug Penetrance into the Central Nervous System |
| title_fullStr | Retinal Electrophysiology Is a Viable Preclinical Biomarker for Drug Penetrance into the Central Nervous System |
| title_full_unstemmed | Retinal Electrophysiology Is a Viable Preclinical Biomarker for Drug Penetrance into the Central Nervous System |
| title_short | Retinal Electrophysiology Is a Viable Preclinical Biomarker for Drug Penetrance into the Central Nervous System |
| title_sort | retinal electrophysiology is a viable preclinical biomarker for drug penetrance into the central nervous system |
| url | http://dx.doi.org/10.1155/2016/5801826 |
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