Preclinical Science Regarding Cannabinoids as Analgesics: An Overview
Modern pharmacology of cannabinoids began in 1964 with the isolation and partial synthesis of delta-9-tetrahydrocannabinol, the main psychoactive agent in herbal cannabis. Since then, potent antinociceptive and antihyperalgesic effects of cannabinoid agonists in animal models of acute and chronic pa...
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| Format: | Article |
| Language: | English |
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Wiley
2005-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2005/169093 |
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| _version_ | 1832553283846144000 |
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| author | ME Lynch |
| author_facet | ME Lynch |
| author_sort | ME Lynch |
| collection | DOAJ |
| description | Modern pharmacology of cannabinoids began in 1964 with the isolation and partial synthesis of delta-9-tetrahydrocannabinol, the main psychoactive agent in herbal cannabis. Since then, potent antinociceptive and antihyperalgesic effects of cannabinoid agonists in animal models of acute and chronic pain; the presence of cannabinoid receptors in pain-processing areas of the brain, spinal cord and periphery; and evidence supporting endogenous modulation of pain systems by cannabinoids has provided support that cannabinoids exhibit significant potential as analgesics. The present article presents an overview of the preclinical science. |
| format | Article |
| id | doaj-art-ad3c8366d23d44a9bc616547e0780423 |
| institution | Kabale University |
| issn | 1203-6765 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-ad3c8366d23d44a9bc616547e07804232025-02-03T05:54:31ZengWileyPain Research and Management1203-67652005-01-0110Suppl A7A14A10.1155/2005/169093Preclinical Science Regarding Cannabinoids as Analgesics: An OverviewME Lynch0Pain Management Unit, Queen Elizabeth II Health Sciences Centre, Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, CanadaModern pharmacology of cannabinoids began in 1964 with the isolation and partial synthesis of delta-9-tetrahydrocannabinol, the main psychoactive agent in herbal cannabis. Since then, potent antinociceptive and antihyperalgesic effects of cannabinoid agonists in animal models of acute and chronic pain; the presence of cannabinoid receptors in pain-processing areas of the brain, spinal cord and periphery; and evidence supporting endogenous modulation of pain systems by cannabinoids has provided support that cannabinoids exhibit significant potential as analgesics. The present article presents an overview of the preclinical science.http://dx.doi.org/10.1155/2005/169093 |
| spellingShingle | ME Lynch Preclinical Science Regarding Cannabinoids as Analgesics: An Overview Pain Research and Management |
| title | Preclinical Science Regarding Cannabinoids as Analgesics: An Overview |
| title_full | Preclinical Science Regarding Cannabinoids as Analgesics: An Overview |
| title_fullStr | Preclinical Science Regarding Cannabinoids as Analgesics: An Overview |
| title_full_unstemmed | Preclinical Science Regarding Cannabinoids as Analgesics: An Overview |
| title_short | Preclinical Science Regarding Cannabinoids as Analgesics: An Overview |
| title_sort | preclinical science regarding cannabinoids as analgesics an overview |
| url | http://dx.doi.org/10.1155/2005/169093 |
| work_keys_str_mv | AT melynch preclinicalscienceregardingcannabinoidsasanalgesicsanoverview |