Paraneoplastic pemphigus involved oral mucosa only: a case report and literature review
Paraneoplastic pemphigus (PNP) is a rare and potentially fatal autoimmune disease that primarily affects the mucocutaneous tissues. Here we present the clinical features of a patient with the lichenoid variant of PNP involving the oral mucosa only. The patient exhibited clinical manifestations resem...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1498800/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585087776980992 |
|---|---|
| author | Xixi Yu Mei Yang Caixia Wang Wanchun Wang Tingting Zhu Yang Liu |
| author_facet | Xixi Yu Mei Yang Caixia Wang Wanchun Wang Tingting Zhu Yang Liu |
| author_sort | Xixi Yu |
| collection | DOAJ |
| description | Paraneoplastic pemphigus (PNP) is a rare and potentially fatal autoimmune disease that primarily affects the mucocutaneous tissues. Here we present the clinical features of a patient with the lichenoid variant of PNP involving the oral mucosa only. The patient exhibited clinical manifestations resembling both lichen planus and pemphigus, yet these lesions remained unresponsive to corticosteroid therapy. A chest computed tomography (CT) scan revealed Castleman disease. Following surgical removal of the tumor, the patient’s oral mucosa healed completely, with no recurrence observed in a 4-year follow-up period. These findings emphasize the importance of considering PNP as a potential diagnosis in patients with refractory oral erosions displaying lichen planus-like and pemphigus-like features, particularly when unresponsive to corticosteroid therapy. A thoracic-abdominal-pelvic CT scan is recommended to facilitate accurate diagnosis and appropriate treatment. |
| format | Article |
| id | doaj-art-ad31fd3e64674449ab5a1e70cde49a58 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-ad31fd3e64674449ab5a1e70cde49a582025-01-27T05:14:31ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011210.3389/fmed.2025.14988001498800Paraneoplastic pemphigus involved oral mucosa only: a case report and literature reviewXixi Yu0Mei Yang1Caixia Wang2Wanchun Wang3Tingting Zhu4Yang Liu5Department of Oral Mucosa, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, ChinaDepartment of Oral Mucosa, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, ChinaDepartment of Oral Mucosa, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, ChinaDepartment of Oral Mucosa, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, ChinaDepartment of Oral Mucosa, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, ChinaDepartment of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing, ChinaParaneoplastic pemphigus (PNP) is a rare and potentially fatal autoimmune disease that primarily affects the mucocutaneous tissues. Here we present the clinical features of a patient with the lichenoid variant of PNP involving the oral mucosa only. The patient exhibited clinical manifestations resembling both lichen planus and pemphigus, yet these lesions remained unresponsive to corticosteroid therapy. A chest computed tomography (CT) scan revealed Castleman disease. Following surgical removal of the tumor, the patient’s oral mucosa healed completely, with no recurrence observed in a 4-year follow-up period. These findings emphasize the importance of considering PNP as a potential diagnosis in patients with refractory oral erosions displaying lichen planus-like and pemphigus-like features, particularly when unresponsive to corticosteroid therapy. A thoracic-abdominal-pelvic CT scan is recommended to facilitate accurate diagnosis and appropriate treatment.https://www.frontiersin.org/articles/10.3389/fmed.2025.1498800/fullparaneoplastic pemphigusneoplasmsautoimmune diseaseautoantibodiesoral mucosa |
| spellingShingle | Xixi Yu Mei Yang Caixia Wang Wanchun Wang Tingting Zhu Yang Liu Paraneoplastic pemphigus involved oral mucosa only: a case report and literature review Frontiers in Medicine paraneoplastic pemphigus neoplasms autoimmune disease autoantibodies oral mucosa |
| title | Paraneoplastic pemphigus involved oral mucosa only: a case report and literature review |
| title_full | Paraneoplastic pemphigus involved oral mucosa only: a case report and literature review |
| title_fullStr | Paraneoplastic pemphigus involved oral mucosa only: a case report and literature review |
| title_full_unstemmed | Paraneoplastic pemphigus involved oral mucosa only: a case report and literature review |
| title_short | Paraneoplastic pemphigus involved oral mucosa only: a case report and literature review |
| title_sort | paraneoplastic pemphigus involved oral mucosa only a case report and literature review |
| topic | paraneoplastic pemphigus neoplasms autoimmune disease autoantibodies oral mucosa |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1498800/full |
| work_keys_str_mv | AT xixiyu paraneoplasticpemphigusinvolvedoralmucosaonlyacasereportandliteraturereview AT meiyang paraneoplasticpemphigusinvolvedoralmucosaonlyacasereportandliteraturereview AT caixiawang paraneoplasticpemphigusinvolvedoralmucosaonlyacasereportandliteraturereview AT wanchunwang paraneoplasticpemphigusinvolvedoralmucosaonlyacasereportandliteraturereview AT tingtingzhu paraneoplasticpemphigusinvolvedoralmucosaonlyacasereportandliteraturereview AT yangliu paraneoplasticpemphigusinvolvedoralmucosaonlyacasereportandliteraturereview |