Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis
Inflammation, as a feature of rheumatoid arthritis (RA), leads to the activation of endothelial cells (ECs). Activated ECs induce atherosclerosis through an increased expression of leukocyte adhesion molecules. Endothelial dysfunction (ED) is recognized as a failure of endothelial repair mechanisms....
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/6813016 |
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| _version_ | 1850169994864754688 |
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| author | XueZhi Yang Yan Chang Wei Wei |
| author_facet | XueZhi Yang Yan Chang Wei Wei |
| author_sort | XueZhi Yang |
| collection | DOAJ |
| description | Inflammation, as a feature of rheumatoid arthritis (RA), leads to the activation of endothelial cells (ECs). Activated ECs induce atherosclerosis through an increased expression of leukocyte adhesion molecules. Endothelial dysfunction (ED) is recognized as a failure of endothelial repair mechanisms. It is also an early preclinical marker of atherosclerosis and is commonly found in RA patients. RA is now established as an independent cardiovascular risk factor, while mechanistic determinants of ED in RA are still poorly understood. An expanding body of study has shown that EC at a site of RA is both active participant and regulator of inflammatory process. Over the last decade, a role for endothelial dysfunction in RA associated with cardiovascular disease (CVD) has been hypothesized. At the same time, several maintenance drugs targeting this phenomenon have been tested, which has promising results. Assessment of endothelial function may be a useful tool to identify and monitor RA patients. |
| format | Article |
| id | doaj-art-ad27db4318694b2687c4f1ee3473ce08 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-ad27db4318694b2687c4f1ee3473ce082025-08-20T02:20:36ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/68130166813016Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid ArthritisXueZhi Yang0Yan Chang1Wei Wei2Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Hefei 230032, ChinaInstitute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Hefei 230032, ChinaInstitute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Hefei 230032, ChinaInflammation, as a feature of rheumatoid arthritis (RA), leads to the activation of endothelial cells (ECs). Activated ECs induce atherosclerosis through an increased expression of leukocyte adhesion molecules. Endothelial dysfunction (ED) is recognized as a failure of endothelial repair mechanisms. It is also an early preclinical marker of atherosclerosis and is commonly found in RA patients. RA is now established as an independent cardiovascular risk factor, while mechanistic determinants of ED in RA are still poorly understood. An expanding body of study has shown that EC at a site of RA is both active participant and regulator of inflammatory process. Over the last decade, a role for endothelial dysfunction in RA associated with cardiovascular disease (CVD) has been hypothesized. At the same time, several maintenance drugs targeting this phenomenon have been tested, which has promising results. Assessment of endothelial function may be a useful tool to identify and monitor RA patients.http://dx.doi.org/10.1155/2016/6813016 |
| spellingShingle | XueZhi Yang Yan Chang Wei Wei Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis Mediators of Inflammation |
| title | Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis |
| title_full | Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis |
| title_fullStr | Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis |
| title_full_unstemmed | Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis |
| title_short | Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis |
| title_sort | endothelial dysfunction and inflammation immunity in rheumatoid arthritis |
| url | http://dx.doi.org/10.1155/2016/6813016 |
| work_keys_str_mv | AT xuezhiyang endothelialdysfunctionandinflammationimmunityinrheumatoidarthritis AT yanchang endothelialdysfunctionandinflammationimmunityinrheumatoidarthritis AT weiwei endothelialdysfunctionandinflammationimmunityinrheumatoidarthritis |