Clinical Characteristics and Long-term Outcomes of Gastric Neuroendocrine Tumors
Background/Aims: Gastric neuroendocrine tumors (GNETs), once rare, have become more prevalent due to the increased use of endoscopy and increased physician awareness. The clinical characteristics and long-term outcomes of GNET management were explored in this study. Methods: The clinical data of 69...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Gastroenterology Council for Gut and Liver
2025-03-01
|
| Series: | Gut and Liver |
| Subjects: | |
| Online Access: | http://gutnliver.org/journal/view.html?doi=10.5009/gnl240272 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850222080001310720 |
|---|---|
| author | Quanxin Zheng Ji Yoon Kim Soo-Jeong Cho Sang Gyun Kim Hyunsoo Chung |
| author_facet | Quanxin Zheng Ji Yoon Kim Soo-Jeong Cho Sang Gyun Kim Hyunsoo Chung |
| author_sort | Quanxin Zheng |
| collection | DOAJ |
| description | Background/Aims: Gastric neuroendocrine tumors (GNETs), once rare, have become more prevalent due to the increased use of endoscopy and increased physician awareness. The clinical characteristics and long-term outcomes of GNET management were explored in this study. Methods: The clinical data of 69 patients who treated at Seoul National University Hospital between January 2013 and October 2023 were retrospectively studied. Baseline characteristics, recurrence rates, associated factors, and overall survival rates were analyzed. Results: Of the tumors, 71.0% were grade 1, 24.6% were grade 2, 1.4% were grade 3, and 2.9% were poorly differentiated. In terms of tumor type, 69.6% were type I, 1.4% were type II, and 29.0% were type III. A significant proportion of patients with grade 1 tumors received more endoscopic treatment, whereas a significant proportion of patients with grade 2 tumors underwent surgery or chemotherapy (p=0.015). The overall 5-year survival and recurrence rates were 93.8% and 7.25% (5/69), respectively. Among five patients who experienced recurrence, three had metachronous recurrence, all of which were type I; the remaining two patients exhibited distant hepatic metastasis, encompassing types I and III. The time to recurrence was 1 to 9.8 years. Margin positivity (p=0.002) and invasion deeper than the submucosal layer (p=0.007) were associated with higher recurrence rates. However, there was no significant association between recurrence and intestinal metaplasia, atrophic gastritis, or Helicobacter pylori infection. Conclusions: Most patients with GNETs in this study had grade I and type I tumors, and the overall prognosis was favorable. Patients with risk factors for recurrence warrant further investigation. Those presenting margin positivity or deep invasion after resection should be closely monitored and undergo follow-up examinations, as necessary. |
| format | Article |
| id | doaj-art-ad1e00a842e14706a67a3538d0d3065b |
| institution | OA Journals |
| issn | 1976-2283 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Gastroenterology Council for Gut and Liver |
| record_format | Article |
| series | Gut and Liver |
| spelling | doaj-art-ad1e00a842e14706a67a3538d0d3065b2025-08-20T02:06:28ZengGastroenterology Council for Gut and LiverGut and Liver1976-22832025-03-0119218919710.5009/gnl240272gnl240272Clinical Characteristics and Long-term Outcomes of Gastric Neuroendocrine TumorsQuanxin Zheng0Ji Yoon Kim1Soo-Jeong Cho2Sang Gyun Kim3Hyunsoo Chung4Department of Medicine, Seoul National University Graduate School, Seoul, KoreaDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, KoreaDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, KoreaDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, KoreaDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, KoreaBackground/Aims: Gastric neuroendocrine tumors (GNETs), once rare, have become more prevalent due to the increased use of endoscopy and increased physician awareness. The clinical characteristics and long-term outcomes of GNET management were explored in this study. Methods: The clinical data of 69 patients who treated at Seoul National University Hospital between January 2013 and October 2023 were retrospectively studied. Baseline characteristics, recurrence rates, associated factors, and overall survival rates were analyzed. Results: Of the tumors, 71.0% were grade 1, 24.6% were grade 2, 1.4% were grade 3, and 2.9% were poorly differentiated. In terms of tumor type, 69.6% were type I, 1.4% were type II, and 29.0% were type III. A significant proportion of patients with grade 1 tumors received more endoscopic treatment, whereas a significant proportion of patients with grade 2 tumors underwent surgery or chemotherapy (p=0.015). The overall 5-year survival and recurrence rates were 93.8% and 7.25% (5/69), respectively. Among five patients who experienced recurrence, three had metachronous recurrence, all of which were type I; the remaining two patients exhibited distant hepatic metastasis, encompassing types I and III. The time to recurrence was 1 to 9.8 years. Margin positivity (p=0.002) and invasion deeper than the submucosal layer (p=0.007) were associated with higher recurrence rates. However, there was no significant association between recurrence and intestinal metaplasia, atrophic gastritis, or Helicobacter pylori infection. Conclusions: Most patients with GNETs in this study had grade I and type I tumors, and the overall prognosis was favorable. Patients with risk factors for recurrence warrant further investigation. Those presenting margin positivity or deep invasion after resection should be closely monitored and undergo follow-up examinations, as necessary.http://gutnliver.org/journal/view.html?doi=10.5009/gnl240272neuroendocrine tumorsendoscopy, gastrointestinalsurgical procedures, operativetherapeuticsrecurrence |
| spellingShingle | Quanxin Zheng Ji Yoon Kim Soo-Jeong Cho Sang Gyun Kim Hyunsoo Chung Clinical Characteristics and Long-term Outcomes of Gastric Neuroendocrine Tumors Gut and Liver neuroendocrine tumors endoscopy, gastrointestinal surgical procedures, operative therapeutics recurrence |
| title | Clinical Characteristics and Long-term Outcomes of Gastric Neuroendocrine Tumors |
| title_full | Clinical Characteristics and Long-term Outcomes of Gastric Neuroendocrine Tumors |
| title_fullStr | Clinical Characteristics and Long-term Outcomes of Gastric Neuroendocrine Tumors |
| title_full_unstemmed | Clinical Characteristics and Long-term Outcomes of Gastric Neuroendocrine Tumors |
| title_short | Clinical Characteristics and Long-term Outcomes of Gastric Neuroendocrine Tumors |
| title_sort | clinical characteristics and long term outcomes of gastric neuroendocrine tumors |
| topic | neuroendocrine tumors endoscopy, gastrointestinal surgical procedures, operative therapeutics recurrence |
| url | http://gutnliver.org/journal/view.html?doi=10.5009/gnl240272 |
| work_keys_str_mv | AT quanxinzheng clinicalcharacteristicsandlongtermoutcomesofgastricneuroendocrinetumors AT jiyoonkim clinicalcharacteristicsandlongtermoutcomesofgastricneuroendocrinetumors AT soojeongcho clinicalcharacteristicsandlongtermoutcomesofgastricneuroendocrinetumors AT sanggyunkim clinicalcharacteristicsandlongtermoutcomesofgastricneuroendocrinetumors AT hyunsoochung clinicalcharacteristicsandlongtermoutcomesofgastricneuroendocrinetumors |