Exosomal PVRL4 Promotes Lung Adenocarcinoma Progression by Enhancing the Generation of Myeloid‐Derived Suppressor Cell‐Secreted TGF‐β1

Exosomal PVRL4 Promotes Lung Adenocarcinoma Progression by Enhancing the Generation of Myeloid‐Derived Suppressor Cell‐Secreted TGF‐β1

ABSTRACT Background The cancer cell marker poliovirus receptor‐like protein 4 (PVRL4) has been shown to be highly expressed in many cancers, including lung cancer. Myeloid‐derived suppressor cells (MDSCs) are a population of immature myeloid cells with immunosuppressive roles that can attenuate the...

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Bibliographic Details
Main Authors: Yahai Liang, Jinmei Li, Lihua Zhang, Jinling Zhou, Meilian Liu, Xiaoxia Peng, Weizhen Zheng, Zhennan Lai
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Thoracic Cancer
Subjects:
exosome
immunosuppressive activity
LUAD
MDSCs
PBMCs
PVRL4
Online Access:https://doi.org/10.1111/1759-7714.15495
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