The temporal relationship between the neural and vascular actions of kallidin within the nose
The time course of effect of the B2-receptor agonist kallidin (K) on induced changes of nasal airflow, rhinorrhoea, nasal pain, sneezing and nasal microvascular leakage has been examined and compared with its B2 metabolite agonist bradykinin (B) and the B1-agonist [des-arg9]-bradykinin (D). When adm...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1993-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935193000298 |
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| _version_ | 1832549252465688576 |
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| author | K. Rajakulasingam L. C. K. Lau R. Polosa M. K. Church S. T. Holgate P. H. Howarth |
| author_facet | K. Rajakulasingam L. C. K. Lau R. Polosa M. K. Church S. T. Holgate P. H. Howarth |
| author_sort | K. Rajakulasingam |
| collection | DOAJ |
| description | The time course of effect of the B2-receptor agonist kallidin (K) on induced changes of nasal airflow, rhinorrhoea, nasal pain, sneezing and nasal microvascular leakage has been examined and compared with its B2 metabolite agonist bradykinin (B) and the B1-agonist [des-arg9]-bradykinin (D). When administered as a single dose K and B induced an immediate sensation of pain, rhinorrhoea, elevations in lavage albumin and protein levels and a sustained increase in nasal airways resistance (NAR) for 5–40 min post-challenge. [des-arg9]-Bradykinin and vehicle placebo (V) were without effect on any of these indices. These studies identify the action of K and B within the nose and differentiate the neural and vascular effects of these kinins in addition to suggesting the potential that nasal blockage and nasal microvascular leakage represent alterations in differing vascular compartments. These findings have implications for the understanding and therapeutic manipulation of rhinitis. |
| format | Article |
| id | doaj-art-ad179ee0a30d49d0acb4ab9de08e32a1 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1993-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-ad179ee0a30d49d0acb4ab9de08e32a12025-02-03T06:11:49ZengWileyMediators of Inflammation0962-93511466-18611993-01-012321722310.1155/S0962935193000298The temporal relationship between the neural and vascular actions of kallidin within the noseK. Rajakulasingam0L. C. K. Lau1R. Polosa2M. K. Church3S. T. Holgate4P. H. Howarth5Immunopharmacology Group, Centre Block, Southampton General Hospital, Tremona Road, Southampton, SO9 4XY, UKImmunopharmacology Group, Centre Block, Southampton General Hospital, Tremona Road, Southampton, SO9 4XY, UKImmunopharmacology Group, Centre Block, Southampton General Hospital, Tremona Road, Southampton, SO9 4XY, UKImmunopharmacology Group, Centre Block, Southampton General Hospital, Tremona Road, Southampton, SO9 4XY, UKImmunopharmacology Group, Centre Block, Southampton General Hospital, Tremona Road, Southampton, SO9 4XY, UKImmunopharmacology Group, Centre Block, Southampton General Hospital, Tremona Road, Southampton, SO9 4XY, UKThe time course of effect of the B2-receptor agonist kallidin (K) on induced changes of nasal airflow, rhinorrhoea, nasal pain, sneezing and nasal microvascular leakage has been examined and compared with its B2 metabolite agonist bradykinin (B) and the B1-agonist [des-arg9]-bradykinin (D). When administered as a single dose K and B induced an immediate sensation of pain, rhinorrhoea, elevations in lavage albumin and protein levels and a sustained increase in nasal airways resistance (NAR) for 5–40 min post-challenge. [des-arg9]-Bradykinin and vehicle placebo (V) were without effect on any of these indices. These studies identify the action of K and B within the nose and differentiate the neural and vascular effects of these kinins in addition to suggesting the potential that nasal blockage and nasal microvascular leakage represent alterations in differing vascular compartments. These findings have implications for the understanding and therapeutic manipulation of rhinitis.http://dx.doi.org/10.1155/S0962935193000298 |
| spellingShingle | K. Rajakulasingam L. C. K. Lau R. Polosa M. K. Church S. T. Holgate P. H. Howarth The temporal relationship between the neural and vascular actions of kallidin within the nose Mediators of Inflammation |
| title | The temporal relationship between the neural and vascular actions of kallidin within the nose |
| title_full | The temporal relationship between the neural and vascular actions of kallidin within the nose |
| title_fullStr | The temporal relationship between the neural and vascular actions of kallidin within the nose |
| title_full_unstemmed | The temporal relationship between the neural and vascular actions of kallidin within the nose |
| title_short | The temporal relationship between the neural and vascular actions of kallidin within the nose |
| title_sort | temporal relationship between the neural and vascular actions of kallidin within the nose |
| url | http://dx.doi.org/10.1155/S0962935193000298 |
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