Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing Neurons
The K-Cl cotransporter KCC2 plays a crucial role in the functional development of GABAA-mediated responses rendering GABA hyperpolarizing in adult neurons. We have previously shown that BDNF upregulates KCC2 in immature neurons through the transcription factor Egr4. The effect of BDNF on Egr4 and KC...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2011/641248 |
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| author | Anastasia Ludwig Pavel Uvarov Christophe Pellegrino Judith Thomas-Crusells Sebastian Schuchmann Mart Saarma Matti S. Airaksinen Claudio Rivera |
| author_facet | Anastasia Ludwig Pavel Uvarov Christophe Pellegrino Judith Thomas-Crusells Sebastian Schuchmann Mart Saarma Matti S. Airaksinen Claudio Rivera |
| author_sort | Anastasia Ludwig |
| collection | DOAJ |
| description | The K-Cl cotransporter KCC2 plays a crucial role in the functional development of GABAA-mediated responses rendering GABA hyperpolarizing in adult neurons. We have previously shown that BDNF upregulates KCC2 in immature neurons through the transcription factor Egr4. The effect of BDNF on Egr4 and KCC2 was shown to be dependent on the activation of ERK1/2. Here we demonstrate that the trophic factor neurturin can also trigger Egr4 expression and upregulate KCC2 in an ERK1/2-dependent manner. These results show that Egr4 is an important component in the mechanism for trophic factor-mediated upregulation of KCC2 in immature neurons involving the activation of specific intracellular pathways common to BDNF and Neurturin. |
| format | Article |
| id | doaj-art-acfc5c0bebc74ac6b462587de5a17a63 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-acfc5c0bebc74ac6b462587de5a17a632025-02-03T05:58:59ZengWileyNeural Plasticity2090-59041687-54432011-01-01201110.1155/2011/641248641248Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing NeuronsAnastasia Ludwig0Pavel Uvarov1Christophe Pellegrino2Judith Thomas-Crusells3Sebastian Schuchmann4Mart Saarma5Matti S. Airaksinen6Claudio Rivera7Neuroscience Center, University of Helsinki, Viikinkaari 4, 00014 Helsinki, FinlandNeuroscience Center, University of Helsinki, Viikinkaari 4, 00014 Helsinki, FinlandNeuroscience Center, University of Helsinki, Viikinkaari 4, 00014 Helsinki, FinlandInstitute of Biotechnology, University of Helsinki, Viikki Campus, Viikinkaari 9, 00014 Helsinki, FinlandNeuroscience Research Center, Charité-Universitätsmedizin, 10117 Berlin, GermanyInstitute of Biotechnology, University of Helsinki, Viikki Campus, Viikinkaari 9, 00014 Helsinki, FinlandNeuroscience Center, University of Helsinki, Viikinkaari 4, 00014 Helsinki, FinlandNeuroscience Center, University of Helsinki, Viikinkaari 4, 00014 Helsinki, FinlandThe K-Cl cotransporter KCC2 plays a crucial role in the functional development of GABAA-mediated responses rendering GABA hyperpolarizing in adult neurons. We have previously shown that BDNF upregulates KCC2 in immature neurons through the transcription factor Egr4. The effect of BDNF on Egr4 and KCC2 was shown to be dependent on the activation of ERK1/2. Here we demonstrate that the trophic factor neurturin can also trigger Egr4 expression and upregulate KCC2 in an ERK1/2-dependent manner. These results show that Egr4 is an important component in the mechanism for trophic factor-mediated upregulation of KCC2 in immature neurons involving the activation of specific intracellular pathways common to BDNF and Neurturin.http://dx.doi.org/10.1155/2011/641248 |
| spellingShingle | Anastasia Ludwig Pavel Uvarov Christophe Pellegrino Judith Thomas-Crusells Sebastian Schuchmann Mart Saarma Matti S. Airaksinen Claudio Rivera Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing Neurons Neural Plasticity |
| title | Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing Neurons |
| title_full | Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing Neurons |
| title_fullStr | Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing Neurons |
| title_full_unstemmed | Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing Neurons |
| title_short | Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing Neurons |
| title_sort | neurturin evokes mapk dependent upregulation of egr4 and kcc2 in developing neurons |
| url | http://dx.doi.org/10.1155/2011/641248 |
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