The modulating effect of coat color mutations on the generation and neutralization of reactive oxygen species in the Аmerican mink (Neovison vison) as a model
The influence of gene mutations encoding coat color on parameters of reactive oxygen species (RO S) generation and neutralization in six organs of the mink (Neovison vison) was evaluated. The study was conducted with standard dark brown (+/+), monorecessive royal pastel (b/b) and silver-blue (р/р),...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2015-07-01
|
| Series: | Вавиловский журнал генетики и селекции |
| Subjects: | |
| Online Access: | https://vavilov.elpub.ru/jour/article/view/411 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832575250635685888 |
|---|---|
| author | S. N. Sergina V. A. Ilyukha I. V. Baishnikova T. N. Ilyina |
| author_facet | S. N. Sergina V. A. Ilyukha I. V. Baishnikova T. N. Ilyina |
| author_sort | S. N. Sergina |
| collection | DOAJ |
| description | The influence of gene mutations encoding coat color on parameters of reactive oxygen species (RO S) generation and neutralization in six organs of the mink (Neovison vison) was evaluated. The study was conducted with standard dark brown (+/+), monorecessive royal pastel (b/b) and silver-blue (р/р), and direcessive sapphire (a/a р/р) mutant minks. It was found that the functioning of both RO S generation and neutralization systems was genotypespecific. The direcessive sapphire (a/a р/р) combination induced high levels of antioxidant enzymes’ activities as well as of thiobarbituric acid-reactive products (TBА-RPs), characterizing lipid peroxidation level. In heart tissue, coat color mutations exerted modulating effects on both RO S generation and the level of low-molecular-weight antioxidants. The royal pastel (b/b) genotype showed the highest level of RO S generation, and the sapphire (a/a р/р), the lowest (statistically significant difference from standard). Coat color mutations modulate the dintensity of RO S generation and neutralization in lung tissue. On the one hand, royal pastel (b/b) in comparison with standard dark brown (+/+) decreases the total level of RO S generation, and on the other hand, it increases the level of generation of superoxide anion-radicals. Cluster analysis, presented in a combined dendrogram, showed that royal pastel (b/b) and sapphire (a/a р/р) minks, the farthest from standard (+/+), had the greatest modulating effects. It is reasonable to suggest that such effects contributed to the genetic plasticity of American mink in the course of colonization of North America and then during mink introduction in Northern Eurasia and South America. |
| format | Article |
| id | doaj-art-acfc0d21b227441f9a421617314bd3d6 |
| institution | Kabale University |
| issn | 2500-3259 |
| language | English |
| publishDate | 2015-07-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj-art-acfc0d21b227441f9a421617314bd3d62025-02-01T09:58:02ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592015-07-0119329630210.18699/VJ15.038370The modulating effect of coat color mutations on the generation and neutralization of reactive oxygen species in the Аmerican mink (Neovison vison) as a modelS. N. Sergina0V. A. Ilyukha1I. V. Baishnikova2T. N. Ilyina3Institute of Biology, Karelian Research Centre, Russian Academy of Sciences, Petrozavodsk, RussiaInstitute of Biology, Karelian Research Centre, Russian Academy of Sciences, Petrozavodsk, RussiaInstitute of Biology, Karelian Research Centre, Russian Academy of Sciences, Petrozavodsk, RussiaInstitute of Biology, Karelian Research Centre, Russian Academy of Sciences, Petrozavodsk, RussiaThe influence of gene mutations encoding coat color on parameters of reactive oxygen species (RO S) generation and neutralization in six organs of the mink (Neovison vison) was evaluated. The study was conducted with standard dark brown (+/+), monorecessive royal pastel (b/b) and silver-blue (р/р), and direcessive sapphire (a/a р/р) mutant minks. It was found that the functioning of both RO S generation and neutralization systems was genotypespecific. The direcessive sapphire (a/a р/р) combination induced high levels of antioxidant enzymes’ activities as well as of thiobarbituric acid-reactive products (TBА-RPs), characterizing lipid peroxidation level. In heart tissue, coat color mutations exerted modulating effects on both RO S generation and the level of low-molecular-weight antioxidants. The royal pastel (b/b) genotype showed the highest level of RO S generation, and the sapphire (a/a р/р), the lowest (statistically significant difference from standard). Coat color mutations modulate the dintensity of RO S generation and neutralization in lung tissue. On the one hand, royal pastel (b/b) in comparison with standard dark brown (+/+) decreases the total level of RO S generation, and on the other hand, it increases the level of generation of superoxide anion-radicals. Cluster analysis, presented in a combined dendrogram, showed that royal pastel (b/b) and sapphire (a/a р/р) minks, the farthest from standard (+/+), had the greatest modulating effects. It is reasonable to suggest that such effects contributed to the genetic plasticity of American mink in the course of colonization of North America and then during mink introduction in Northern Eurasia and South America.https://vavilov.elpub.ru/jour/article/view/411american minkneovison visoncoat color mutationsreactive oxygen speciesantioxidant system |
| spellingShingle | S. N. Sergina V. A. Ilyukha I. V. Baishnikova T. N. Ilyina The modulating effect of coat color mutations on the generation and neutralization of reactive oxygen species in the Аmerican mink (Neovison vison) as a model Вавиловский журнал генетики и селекции american mink neovison vison coat color mutations reactive oxygen species antioxidant system |
| title | The modulating effect of coat color mutations on the generation and neutralization of reactive oxygen species in the Аmerican mink (Neovison vison) as a model |
| title_full | The modulating effect of coat color mutations on the generation and neutralization of reactive oxygen species in the Аmerican mink (Neovison vison) as a model |
| title_fullStr | The modulating effect of coat color mutations on the generation and neutralization of reactive oxygen species in the Аmerican mink (Neovison vison) as a model |
| title_full_unstemmed | The modulating effect of coat color mutations on the generation and neutralization of reactive oxygen species in the Аmerican mink (Neovison vison) as a model |
| title_short | The modulating effect of coat color mutations on the generation and neutralization of reactive oxygen species in the Аmerican mink (Neovison vison) as a model |
| title_sort | modulating effect of coat color mutations on the generation and neutralization of reactive oxygen species in the аmerican mink neovison vison as a model |
| topic | american mink neovison vison coat color mutations reactive oxygen species antioxidant system |
| url | https://vavilov.elpub.ru/jour/article/view/411 |
| work_keys_str_mv | AT snsergina themodulatingeffectofcoatcolormutationsonthegenerationandneutralizationofreactiveoxygenspeciesintheamericanminkneovisonvisonasamodel AT vailyukha themodulatingeffectofcoatcolormutationsonthegenerationandneutralizationofreactiveoxygenspeciesintheamericanminkneovisonvisonasamodel AT ivbaishnikova themodulatingeffectofcoatcolormutationsonthegenerationandneutralizationofreactiveoxygenspeciesintheamericanminkneovisonvisonasamodel AT tnilyina themodulatingeffectofcoatcolormutationsonthegenerationandneutralizationofreactiveoxygenspeciesintheamericanminkneovisonvisonasamodel AT snsergina modulatingeffectofcoatcolormutationsonthegenerationandneutralizationofreactiveoxygenspeciesintheamericanminkneovisonvisonasamodel AT vailyukha modulatingeffectofcoatcolormutationsonthegenerationandneutralizationofreactiveoxygenspeciesintheamericanminkneovisonvisonasamodel AT ivbaishnikova modulatingeffectofcoatcolormutationsonthegenerationandneutralizationofreactiveoxygenspeciesintheamericanminkneovisonvisonasamodel AT tnilyina modulatingeffectofcoatcolormutationsonthegenerationandneutralizationofreactiveoxygenspeciesintheamericanminkneovisonvisonasamodel |