Mesenchymal stem cells transplantation in the treatment of tendon disorders
Introduction and purpose: Tendon disorders are conditions that lead to pain, reduced mobility, and are often associated with recurrences and complications. A novel therapeutic approach for these conditions is the transplantation of mesenchymal stem cells (MSCs) into the affected area. This paper...
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-01-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/57719 |
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| author | Adrian Różycki Michał Pniak Paweł Miklis Maciej Mawlichanów Aleksandra Ciesielska Aleksandra Sieradzka Krzysztof Szerej Alicja Kot Marta Wojtczak Natalia Myśliwiec |
| author_facet | Adrian Różycki Michał Pniak Paweł Miklis Maciej Mawlichanów Aleksandra Ciesielska Aleksandra Sieradzka Krzysztof Szerej Alicja Kot Marta Wojtczak Natalia Myśliwiec |
| author_sort | Adrian Różycki |
| collection | DOAJ |
| description |
Introduction and purpose:
Tendon disorders are conditions that lead to pain, reduced mobility, and are often associated with recurrences and complications. A novel therapeutic approach for these conditions is the transplantation of mesenchymal stem cells (MSCs) into the affected area. This paper presents knowledge on the use of MSCs for the treatment of tendon disorders. Additionally, it presents advances in research regarding the application of MSC transplantation in the following conditions: rotator cuff tendon injuries, lateral epicondylitis, Achilles tendon disorders, and patellar tendon injuries.
Material and methods:
A review of the PubMed and Google Scholar databases was conducted.
Results:
It is suggested that MSCs support tendon regeneration through the regulation of inflammatory processes, their capacity to differentiate into various cell types, their influence on collagen synthesis, and their effect on the migration and proliferation of tenocytes. Research indicates that transplantation into damaged tendons enhances tendon function and reduces pain. While many studies have not reported the occurrence of side effects, some have noted such cases.
Conclusions:
Further research is required to develop a deeper understanding of the role that MSCs play in the treatment of tendon disorders. Additionally, there is a need to establish precise treatment protocols and evaluate the safety of this procedure.
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| format | Article |
| id | doaj-art-aceee42dce8146778d44b9b10250eb50 |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-aceee42dce8146778d44b9b10250eb502025-02-03T08:23:59ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-01-013710.12775/QS.2025.37.57719Mesenchymal stem cells transplantation in the treatment of tendon disordersAdrian Różycki0https://orcid.org/0000-0002-9110-5443Michał Pniak1https://orcid.org/0009-0006-2982-6078Paweł Miklis2https://orcid.org/0009-0008-4578-233XMaciej Mawlichanów3https://orcid.org/0000-0002-6543-8105Aleksandra Ciesielska4https://orcid.org/0009-0000-5015-6140Aleksandra Sieradzka 5https://orcid.org/0009-0004-2281-7617Krzysztof Szerej6https://orcid.org/0009-0003-7581-4965Alicja Kot7https://orcid.org/0009-0001-2999-6775Marta Wojtczak8https://orcid.org/0009-0007-0032-7520Natalia Myśliwiec 9https://orcid.org/0000-0002-4359-9899Medica Plus Family Clinic Sp. z o. o., Gdańsk, PolandJohn Paul II Memorial Masovia Provincial Hospital in Siedlce, PolandUniversity Clinical Center of the Medical University of Warsaw, PolandMilitary Institute of Medicine, Warsaw PolandMazovian Rehabilitation Center "STOCER" Sp. z o.o. Railway Hospital in Pruszków: Pruszków, PLMedical University of WarsawDistrict Hospital in Sochaczew, Batalionów Chłopskich 3/7, Sochaczew, Poland,Medical University of WarsawCounty Health Center in Otwock Sp. z o.o. Otwock, PolandNational Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland Introduction and purpose: Tendon disorders are conditions that lead to pain, reduced mobility, and are often associated with recurrences and complications. A novel therapeutic approach for these conditions is the transplantation of mesenchymal stem cells (MSCs) into the affected area. This paper presents knowledge on the use of MSCs for the treatment of tendon disorders. Additionally, it presents advances in research regarding the application of MSC transplantation in the following conditions: rotator cuff tendon injuries, lateral epicondylitis, Achilles tendon disorders, and patellar tendon injuries. Material and methods: A review of the PubMed and Google Scholar databases was conducted. Results: It is suggested that MSCs support tendon regeneration through the regulation of inflammatory processes, their capacity to differentiate into various cell types, their influence on collagen synthesis, and their effect on the migration and proliferation of tenocytes. Research indicates that transplantation into damaged tendons enhances tendon function and reduces pain. While many studies have not reported the occurrence of side effects, some have noted such cases. Conclusions: Further research is required to develop a deeper understanding of the role that MSCs play in the treatment of tendon disorders. Additionally, there is a need to establish precise treatment protocols and evaluate the safety of this procedure. https://apcz.umk.pl/QS/article/view/57719Mesenchymal Stem Cellstendon injuriestendon rupturestem cells |
| spellingShingle | Adrian Różycki Michał Pniak Paweł Miklis Maciej Mawlichanów Aleksandra Ciesielska Aleksandra Sieradzka Krzysztof Szerej Alicja Kot Marta Wojtczak Natalia Myśliwiec Mesenchymal stem cells transplantation in the treatment of tendon disorders Quality in Sport Mesenchymal Stem Cells tendon injuries tendon rupture stem cells |
| title | Mesenchymal stem cells transplantation in the treatment of tendon disorders |
| title_full | Mesenchymal stem cells transplantation in the treatment of tendon disorders |
| title_fullStr | Mesenchymal stem cells transplantation in the treatment of tendon disorders |
| title_full_unstemmed | Mesenchymal stem cells transplantation in the treatment of tendon disorders |
| title_short | Mesenchymal stem cells transplantation in the treatment of tendon disorders |
| title_sort | mesenchymal stem cells transplantation in the treatment of tendon disorders |
| topic | Mesenchymal Stem Cells tendon injuries tendon rupture stem cells |
| url | https://apcz.umk.pl/QS/article/view/57719 |
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