Impact of childhood trauma on cognitive function in patients with bipolar disorder
BackgroundPatients with bipolar disorder (BD) frequently exhibit cognitive impairments. However, the association between childhood trauma as a risk factor for BD and cognitive deficits remains ambiguous.ObjectiveTo investigate the relationship between childhood trauma and cognitive function among pa...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1513021/full |
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| author | Zhiyang Zhang Zhiyang Zhang Chenyu Zhou Chenyu Zhou Zhen Mao Zhen Mao Yue Sun Yue Sun Lei Zhao Lei Zhao Tian Li Tian Li Chuanyue Wang Chuanyue Wang Qijing Bo Qijing Bo |
| author_facet | Zhiyang Zhang Zhiyang Zhang Chenyu Zhou Chenyu Zhou Zhen Mao Zhen Mao Yue Sun Yue Sun Lei Zhao Lei Zhao Tian Li Tian Li Chuanyue Wang Chuanyue Wang Qijing Bo Qijing Bo |
| author_sort | Zhiyang Zhang |
| collection | DOAJ |
| description | BackgroundPatients with bipolar disorder (BD) frequently exhibit cognitive impairments. However, the association between childhood trauma as a risk factor for BD and cognitive deficits remains ambiguous.ObjectiveTo investigate the relationship between childhood trauma and cognitive function among patients with BD.MethodsThe study included 90 patients with BD and 94 healthy controls (HC). Childhood trauma was assessed using the Childhood Trauma Questionnaire (CTQ), and cognitive function was evaluated using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The relationships between childhood trauma and cognitive function.ResultsIn BD group, childhood abuse and neglect were more prevalent than in HC group. Mood stabilizer use was positively associated with language abilities, while antipsychotic use negatively impacted attention. Emotional abuse predicted impaired immediate memory, with the number of episodes and valproate dosage negatively correlating with total RBANS scores, whereas education and mood stabilizer use showed positive correlations.ConclusionsThe incidence of childhood trauma was higher among BD than HC, and different types of childhood trauma had varying effects on different aspects of cognition. These studies will deepen the understanding of the complexity of BD and support the development of more effective treatment methods. |
| format | Article |
| id | doaj-art-ace2d6c7ace04f2986a1dcbb1416dccc |
| institution | Kabale University |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-ace2d6c7ace04f2986a1dcbb1416dccc2025-01-23T06:56:24ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-01-011610.3389/fpsyt.2025.15130211513021Impact of childhood trauma on cognitive function in patients with bipolar disorderZhiyang Zhang0Zhiyang Zhang1Chenyu Zhou2Chenyu Zhou3Zhen Mao4Zhen Mao5Yue Sun6Yue Sun7Lei Zhao8Lei Zhao9Tian Li10Tian Li11Chuanyue Wang12Chuanyue Wang13Qijing Bo14Qijing Bo15The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders & Beijing Institute for Brain Disorders Center of Schizophrenia, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaAdvanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, ChinaThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders & Beijing Institute for Brain Disorders Center of Schizophrenia, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaAdvanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, ChinaThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders & Beijing Institute for Brain Disorders Center of Schizophrenia, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaAdvanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, ChinaThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders & Beijing Institute for Brain Disorders Center of Schizophrenia, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaAdvanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, ChinaThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders & Beijing Institute for Brain Disorders Center of Schizophrenia, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaAdvanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, ChinaThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders & Beijing Institute for Brain Disorders Center of Schizophrenia, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaAdvanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, ChinaThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders & Beijing Institute for Brain Disorders Center of Schizophrenia, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaAdvanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, ChinaThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders & Beijing Institute for Brain Disorders Center of Schizophrenia, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaAdvanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, ChinaBackgroundPatients with bipolar disorder (BD) frequently exhibit cognitive impairments. However, the association between childhood trauma as a risk factor for BD and cognitive deficits remains ambiguous.ObjectiveTo investigate the relationship between childhood trauma and cognitive function among patients with BD.MethodsThe study included 90 patients with BD and 94 healthy controls (HC). Childhood trauma was assessed using the Childhood Trauma Questionnaire (CTQ), and cognitive function was evaluated using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The relationships between childhood trauma and cognitive function.ResultsIn BD group, childhood abuse and neglect were more prevalent than in HC group. Mood stabilizer use was positively associated with language abilities, while antipsychotic use negatively impacted attention. Emotional abuse predicted impaired immediate memory, with the number of episodes and valproate dosage negatively correlating with total RBANS scores, whereas education and mood stabilizer use showed positive correlations.ConclusionsThe incidence of childhood trauma was higher among BD than HC, and different types of childhood trauma had varying effects on different aspects of cognition. These studies will deepen the understanding of the complexity of BD and support the development of more effective treatment methods.https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1513021/fullbipolar disorderchildhood traumacognitionneuropsychological assessmentabuse and neglect |
| spellingShingle | Zhiyang Zhang Zhiyang Zhang Chenyu Zhou Chenyu Zhou Zhen Mao Zhen Mao Yue Sun Yue Sun Lei Zhao Lei Zhao Tian Li Tian Li Chuanyue Wang Chuanyue Wang Qijing Bo Qijing Bo Impact of childhood trauma on cognitive function in patients with bipolar disorder Frontiers in Psychiatry bipolar disorder childhood trauma cognition neuropsychological assessment abuse and neglect |
| title | Impact of childhood trauma on cognitive function in patients with bipolar disorder |
| title_full | Impact of childhood trauma on cognitive function in patients with bipolar disorder |
| title_fullStr | Impact of childhood trauma on cognitive function in patients with bipolar disorder |
| title_full_unstemmed | Impact of childhood trauma on cognitive function in patients with bipolar disorder |
| title_short | Impact of childhood trauma on cognitive function in patients with bipolar disorder |
| title_sort | impact of childhood trauma on cognitive function in patients with bipolar disorder |
| topic | bipolar disorder childhood trauma cognition neuropsychological assessment abuse and neglect |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1513021/full |
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