Development of Ketoprofen Impurity A (1-(3-Benzoylphenyl)ethanone) as a Certified Reference Material for Pharmaceutical Quality Control
<b>Background/Objectives</b>: Reference materials are essential for ensuring the accuracy and traceability of measurements in the quality control of medicinal products. This study explores new principles for the preparation of impure materials of active pharmaceutical substances, focusin...
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2025-01-01
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| author | Nikolay A. Shulga Vladimir I. Gegechkori Natalya V. Gorpinchenko Valery V. Smirnov Sergey P. Dementyev Galina V. Ramenskaya |
| author_facet | Nikolay A. Shulga Vladimir I. Gegechkori Natalya V. Gorpinchenko Valery V. Smirnov Sergey P. Dementyev Galina V. Ramenskaya |
| author_sort | Nikolay A. Shulga |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: Reference materials are essential for ensuring the accuracy and traceability of measurements in the quality control of medicinal products. This study explores new principles for the preparation of impure materials of active pharmaceutical substances, focusing on 1-(3-benzoylphenyl)ethanone ketoprofen impurity A (<i>European Pharmacopoeia</i>) as the reference material. <b>Methods</b>: The reference material was synthesised from commercially available acetanilide and benzoyl chloride. The obtained product was purified using preparative chromatography and characterised by infrared spectroscopy (IR), 1H and 13C nuclear magnetic resonance (NMR), and mass spectrometry. The structure was verified using primary research methods to confirm its identity as the target product. <b>Results</b>: The characterisation confirmed the structure and purity of 1-(3-benzoylphenyl)ethanone, achieving a purity of 99.86%, meeting regulatory documentation requirements. The synthesised product was demonstrated to be identical to the target compound and suitable for use as a reference material. <b>Conclusions</b>: The developed method provides a robust approach for the preparation and characterisation of 1-(3-benzoylphenyl)ethanone, enabling its use as a certified reference material in the quality control of medicinal products. This approach ensures compliance with regulatory standards and enhances the reliability of pharmaceutical quality assurance practices. |
| format | Article |
| id | doaj-art-ace2d13ef96d4e8f9133050a7eca6db6 |
| institution | Kabale University |
| issn | 1424-8247 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-ace2d13ef96d4e8f9133050a7eca6db62025-01-24T13:45:13ZengMDPI AGPharmaceuticals1424-82472025-01-011815910.3390/ph18010059Development of Ketoprofen Impurity A (1-(3-Benzoylphenyl)ethanone) as a Certified Reference Material for Pharmaceutical Quality ControlNikolay A. Shulga0Vladimir I. Gegechkori1Natalya V. Gorpinchenko2Valery V. Smirnov3Sergey P. Dementyev4Galina V. Ramenskaya5Department of Pharmaceutical and Toxicological Chemistry named after Arzamastsev, Institute of Pharmacy, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 8-2 Trubetskaya Str., 119991 Moscow, RussiaDepartment of Pharmaceutical and Toxicological Chemistry named after Arzamastsev, Institute of Pharmacy, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 8-2 Trubetskaya Str., 119991 Moscow, RussiaDepartment of Pharmaceutical and Toxicological Chemistry named after Arzamastsev, Institute of Pharmacy, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 8-2 Trubetskaya Str., 119991 Moscow, RussiaDepartment of Pharmaceutical and Toxicological Chemistry named after Arzamastsev, Institute of Pharmacy, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 8-2 Trubetskaya Str., 119991 Moscow, RussiaDepartment of Pharmaceutical and Toxicological Chemistry named after Arzamastsev, Institute of Pharmacy, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 8-2 Trubetskaya Str., 119991 Moscow, RussiaDepartment of Pharmaceutical and Toxicological Chemistry named after Arzamastsev, Institute of Pharmacy, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 8-2 Trubetskaya Str., 119991 Moscow, Russia<b>Background/Objectives</b>: Reference materials are essential for ensuring the accuracy and traceability of measurements in the quality control of medicinal products. This study explores new principles for the preparation of impure materials of active pharmaceutical substances, focusing on 1-(3-benzoylphenyl)ethanone ketoprofen impurity A (<i>European Pharmacopoeia</i>) as the reference material. <b>Methods</b>: The reference material was synthesised from commercially available acetanilide and benzoyl chloride. The obtained product was purified using preparative chromatography and characterised by infrared spectroscopy (IR), 1H and 13C nuclear magnetic resonance (NMR), and mass spectrometry. The structure was verified using primary research methods to confirm its identity as the target product. <b>Results</b>: The characterisation confirmed the structure and purity of 1-(3-benzoylphenyl)ethanone, achieving a purity of 99.86%, meeting regulatory documentation requirements. The synthesised product was demonstrated to be identical to the target compound and suitable for use as a reference material. <b>Conclusions</b>: The developed method provides a robust approach for the preparation and characterisation of 1-(3-benzoylphenyl)ethanone, enabling its use as a certified reference material in the quality control of medicinal products. This approach ensures compliance with regulatory standards and enhances the reliability of pharmaceutical quality assurance practices.https://www.mdpi.com/1424-8247/18/1/59related substancesketoprofen impurityreference materialpurification |
| spellingShingle | Nikolay A. Shulga Vladimir I. Gegechkori Natalya V. Gorpinchenko Valery V. Smirnov Sergey P. Dementyev Galina V. Ramenskaya Development of Ketoprofen Impurity A (1-(3-Benzoylphenyl)ethanone) as a Certified Reference Material for Pharmaceutical Quality Control Pharmaceuticals related substances ketoprofen impurity reference material purification |
| title | Development of Ketoprofen Impurity A (1-(3-Benzoylphenyl)ethanone) as a Certified Reference Material for Pharmaceutical Quality Control |
| title_full | Development of Ketoprofen Impurity A (1-(3-Benzoylphenyl)ethanone) as a Certified Reference Material for Pharmaceutical Quality Control |
| title_fullStr | Development of Ketoprofen Impurity A (1-(3-Benzoylphenyl)ethanone) as a Certified Reference Material for Pharmaceutical Quality Control |
| title_full_unstemmed | Development of Ketoprofen Impurity A (1-(3-Benzoylphenyl)ethanone) as a Certified Reference Material for Pharmaceutical Quality Control |
| title_short | Development of Ketoprofen Impurity A (1-(3-Benzoylphenyl)ethanone) as a Certified Reference Material for Pharmaceutical Quality Control |
| title_sort | development of ketoprofen impurity a 1 3 benzoylphenyl ethanone as a certified reference material for pharmaceutical quality control |
| topic | related substances ketoprofen impurity reference material purification |
| url | https://www.mdpi.com/1424-8247/18/1/59 |
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