miRNAs and Melanoma: How Are They Connected?
miRNAs are non-coding RNAs that bind to mRNA targets and disturb their stability and/or translation, thus acting in gene posttranscriptional regulation. It is predicted that over 30% of mRNAs are regulated by m...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/528345 |
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| _version_ | 1832563516058370048 |
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| author | Adriana Taveira da Cruz Miriam Galvonas Jasiulionis |
| author_facet | Adriana Taveira da Cruz Miriam Galvonas Jasiulionis |
| author_sort | Adriana Taveira da Cruz |
| collection | DOAJ |
| description | miRNAs are non-coding RNAs that bind to mRNA targets and disturb their
stability and/or translation, thus acting in gene posttranscriptional
regulation. It is predicted that over 30% of mRNAs are regulated by
miRNAs. Therefore these molecules are considered essential in the
processing of many biological responses, such as cell proliferation,
apoptosis, and stress responsiveness. As miRNAs participate of
virtually all cellular pathways, their deregulation is critical to
cancer development. Consequently, loss or gain of miRNAs function may
contribute to tumor progression. Little is known about the regulation
of miRNAs and understanding the events that lead to changes in their
expression may provide new perspectives for cancer treatment. Among
distinct types of cancer, melanoma has special implications. It is
characterized as a complex disease, originated from a malignant
transformation of melanocytes. Despite being rare, its metastatic form
is usually incurable, which makes melanoma the major death cause of
all skin cancers. Some molecular pathways are frequently disrupted in
melanoma, and miRNAs probably have a decisive role on these
alterations. Therefore, this review aims to discuss new findings about
miRNAs in melanoma fields, underlying epigenetic processes, and also
to argue possibilities of using miRNAs in melanoma diagnosis and
therapy. |
| format | Article |
| id | doaj-art-acd752e6f1de48f29dc894b3c0cb1414 |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-acd752e6f1de48f29dc894b3c0cb14142025-02-03T01:20:03ZengWileyDermatology Research and Practice1687-61051687-61132012-01-01201210.1155/2012/528345528345miRNAs and Melanoma: How Are They Connected?Adriana Taveira da Cruz0Miriam Galvonas Jasiulionis1Microbiology, Immunology and Parasitology Department, Universidade Federal de São Paulo, 04039-032 São Paulo, SP, BrazilMicrobiology, Immunology and Parasitology Department, Universidade Federal de São Paulo, 04039-032 São Paulo, SP, BrazilmiRNAs are non-coding RNAs that bind to mRNA targets and disturb their stability and/or translation, thus acting in gene posttranscriptional regulation. It is predicted that over 30% of mRNAs are regulated by miRNAs. Therefore these molecules are considered essential in the processing of many biological responses, such as cell proliferation, apoptosis, and stress responsiveness. As miRNAs participate of virtually all cellular pathways, their deregulation is critical to cancer development. Consequently, loss or gain of miRNAs function may contribute to tumor progression. Little is known about the regulation of miRNAs and understanding the events that lead to changes in their expression may provide new perspectives for cancer treatment. Among distinct types of cancer, melanoma has special implications. It is characterized as a complex disease, originated from a malignant transformation of melanocytes. Despite being rare, its metastatic form is usually incurable, which makes melanoma the major death cause of all skin cancers. Some molecular pathways are frequently disrupted in melanoma, and miRNAs probably have a decisive role on these alterations. Therefore, this review aims to discuss new findings about miRNAs in melanoma fields, underlying epigenetic processes, and also to argue possibilities of using miRNAs in melanoma diagnosis and therapy.http://dx.doi.org/10.1155/2012/528345 |
| spellingShingle | Adriana Taveira da Cruz Miriam Galvonas Jasiulionis miRNAs and Melanoma: How Are They Connected? Dermatology Research and Practice |
| title | miRNAs and Melanoma: How Are They Connected? |
| title_full | miRNAs and Melanoma: How Are They Connected? |
| title_fullStr | miRNAs and Melanoma: How Are They Connected? |
| title_full_unstemmed | miRNAs and Melanoma: How Are They Connected? |
| title_short | miRNAs and Melanoma: How Are They Connected? |
| title_sort | mirnas and melanoma how are they connected |
| url | http://dx.doi.org/10.1155/2012/528345 |
| work_keys_str_mv | AT adrianataveiradacruz mirnasandmelanomahowaretheyconnected AT miriamgalvonasjasiulionis mirnasandmelanomahowaretheyconnected |