Systemic and Local CC Chemokines Production in a Murine Model of Listeria monocytogenes Infection
Repeated intragastric inoculation of Listeria monocytogenes into BALB/c mice resulted in prolonged bacteraemia and severe hepatic infection. Bacteria could also be isolated from the brain tissue of all experimental mice. During the inflammatory process, chemokine concentrations typically increased a...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/54202 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562423015407616 |
|---|---|
| author | Marina Bubonja Branka Wraber Gordana Brumini Ivana Gobin Danijela Veljkovic Maja Abram |
| author_facet | Marina Bubonja Branka Wraber Gordana Brumini Ivana Gobin Danijela Veljkovic Maja Abram |
| author_sort | Marina Bubonja |
| collection | DOAJ |
| description | Repeated intragastric inoculation of Listeria
monocytogenes into BALB/c mice resulted in prolonged bacteraemia
and severe hepatic infection. Bacteria could also be isolated from
the brain tissue of all experimental mice. During the inflammatory
process, chemokine concentrations typically increased at the local
site in comparison to the systemic level. The liver-to-serum ratio
was more pronounced in the case of macrophage inflammatory protein
1α (MIP-1α), suggesting its role in the inflammatory response in
the liver. The ratio of brain-to-serum concentration of monocyte
chemoattractant protein 1 (MCP-1) remained the same as in the
control animals, while it was lower in the infected mice, both in
the case MIP-1α and in the case of regulated on activation, normal
T cell expressed and secreted (RANTES). This is in correlation
with slight inflammatory infiltrates found in the brain tissue
early in infection. |
| format | Article |
| id | doaj-art-acc94066034640db96316a6e8314541b |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-acc94066034640db96316a6e8314541b2025-02-03T01:22:39ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/5420254202Systemic and Local CC Chemokines Production in a Murine Model of Listeria monocytogenes InfectionMarina Bubonja0Branka Wraber1Gordana Brumini2Ivana Gobin3Danijela Veljkovic4Maja Abram5Department of Microbiology, Medical Faculty, University of Rijeka, Rijeka 51000, CroatiaInstitute of Microbiology and Immunology, Medical Faculty, University of Ljubljana, Ljubljana 1000, SloveniaDepartment of Medical Informatics, Medical Faculty, University of Rijeka, Rijeka 51000, CroatiaDepartment of Microbiology, Medical Faculty, University of Rijeka, Rijeka 51000, CroatiaDepartment of Microbiology, Medical Faculty, University of Rijeka, Rijeka 51000, CroatiaDepartment of Microbiology, Medical Faculty, University of Rijeka, Rijeka 51000, CroatiaRepeated intragastric inoculation of Listeria monocytogenes into BALB/c mice resulted in prolonged bacteraemia and severe hepatic infection. Bacteria could also be isolated from the brain tissue of all experimental mice. During the inflammatory process, chemokine concentrations typically increased at the local site in comparison to the systemic level. The liver-to-serum ratio was more pronounced in the case of macrophage inflammatory protein 1α (MIP-1α), suggesting its role in the inflammatory response in the liver. The ratio of brain-to-serum concentration of monocyte chemoattractant protein 1 (MCP-1) remained the same as in the control animals, while it was lower in the infected mice, both in the case MIP-1α and in the case of regulated on activation, normal T cell expressed and secreted (RANTES). This is in correlation with slight inflammatory infiltrates found in the brain tissue early in infection.http://dx.doi.org/10.1155/MI/2006/54202 |
| spellingShingle | Marina Bubonja Branka Wraber Gordana Brumini Ivana Gobin Danijela Veljkovic Maja Abram Systemic and Local CC Chemokines Production in a Murine Model of Listeria monocytogenes Infection Mediators of Inflammation |
| title | Systemic and Local CC Chemokines Production in a
Murine Model of Listeria monocytogenes Infection |
| title_full | Systemic and Local CC Chemokines Production in a
Murine Model of Listeria monocytogenes Infection |
| title_fullStr | Systemic and Local CC Chemokines Production in a
Murine Model of Listeria monocytogenes Infection |
| title_full_unstemmed | Systemic and Local CC Chemokines Production in a
Murine Model of Listeria monocytogenes Infection |
| title_short | Systemic and Local CC Chemokines Production in a
Murine Model of Listeria monocytogenes Infection |
| title_sort | systemic and local cc chemokines production in a murine model of listeria monocytogenes infection |
| url | http://dx.doi.org/10.1155/MI/2006/54202 |
| work_keys_str_mv | AT marinabubonja systemicandlocalccchemokinesproductioninamurinemodeloflisteriamonocytogenesinfection AT brankawraber systemicandlocalccchemokinesproductioninamurinemodeloflisteriamonocytogenesinfection AT gordanabrumini systemicandlocalccchemokinesproductioninamurinemodeloflisteriamonocytogenesinfection AT ivanagobin systemicandlocalccchemokinesproductioninamurinemodeloflisteriamonocytogenesinfection AT danijelaveljkovic systemicandlocalccchemokinesproductioninamurinemodeloflisteriamonocytogenesinfection AT majaabram systemicandlocalccchemokinesproductioninamurinemodeloflisteriamonocytogenesinfection |