Systemic and Local CC Chemokines Production in a Murine Model of Listeria monocytogenes Infection
Repeated intragastric inoculation of Listeria monocytogenes into BALB/c mice resulted in prolonged bacteraemia and severe hepatic infection. Bacteria could also be isolated from the brain tissue of all experimental mice. During the inflammatory process, chemokine concentrations typically increased a...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/54202 |
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| Summary: | Repeated intragastric inoculation of Listeria
monocytogenes into BALB/c mice resulted in prolonged bacteraemia
and severe hepatic infection. Bacteria could also be isolated from
the brain tissue of all experimental mice. During the inflammatory
process, chemokine concentrations typically increased at the local
site in comparison to the systemic level. The liver-to-serum ratio
was more pronounced in the case of macrophage inflammatory protein
1α (MIP-1α), suggesting its role in the inflammatory response in
the liver. The ratio of brain-to-serum concentration of monocyte
chemoattractant protein 1 (MCP-1) remained the same as in the
control animals, while it was lower in the infected mice, both in
the case MIP-1α and in the case of regulated on activation, normal
T cell expressed and secreted (RANTES). This is in correlation
with slight inflammatory infiltrates found in the brain tissue
early in infection. |
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| ISSN: | 0962-9351 1466-1861 |